Evolutionary tradeoffs between economy and effectiveness in biological homeostasis systems.

Biological regulatory systems face a fundamental tradeoff: they must be effective but at the same time also economical. For example, regulatory systems that are designed to repair damage must be effective in reducing damage, but economical in not making too many repair proteins because making excess...

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Autores principales:	Pablo Szekely, Hila Sheftel, Avi Mayo, Uri Alon
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/3270d86ec45a4b049ae8a4589677f192
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spelling	oai:doaj.org-article:3270d86ec45a4b049ae8a4589677f1922021-11-18T05:53:41ZEvolutionary tradeoffs between economy and effectiveness in biological homeostasis systems.1553-734X1553-735810.1371/journal.pcbi.1003163https://doaj.org/article/3270d86ec45a4b049ae8a4589677f1922013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23950698/?tool=EBIhttps://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358Biological regulatory systems face a fundamental tradeoff: they must be effective but at the same time also economical. For example, regulatory systems that are designed to repair damage must be effective in reducing damage, but economical in not making too many repair proteins because making excessive proteins carries a fitness cost to the cell, called protein burden. In order to see how biological systems compromise between the two tasks of effectiveness and economy, we applied an approach from economics and engineering called Pareto optimality. This approach allows calculating the best-compromise systems that optimally combine the two tasks. We used a simple and general model for regulation, known as integral feedback, and showed that best-compromise systems have particular combinations of biochemical parameters that control the response rate and basal level. We find that the optimal systems fall on a curve in parameter space. Due to this feature, even if one is able to measure only a small fraction of the system's parameters, one can infer the rest. We applied this approach to estimate parameters in three biological systems: response to heat shock and response to DNA damage in bacteria, and calcium homeostasis in mammals.Pablo SzekelyHila SheftelAvi MayoUri AlonPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 9, Iss 8, p e1003163 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Pablo Szekely Hila Sheftel Avi Mayo Uri Alon Evolutionary tradeoffs between economy and effectiveness in biological homeostasis systems.
description	Biological regulatory systems face a fundamental tradeoff: they must be effective but at the same time also economical. For example, regulatory systems that are designed to repair damage must be effective in reducing damage, but economical in not making too many repair proteins because making excessive proteins carries a fitness cost to the cell, called protein burden. In order to see how biological systems compromise between the two tasks of effectiveness and economy, we applied an approach from economics and engineering called Pareto optimality. This approach allows calculating the best-compromise systems that optimally combine the two tasks. We used a simple and general model for regulation, known as integral feedback, and showed that best-compromise systems have particular combinations of biochemical parameters that control the response rate and basal level. We find that the optimal systems fall on a curve in parameter space. Due to this feature, even if one is able to measure only a small fraction of the system's parameters, one can infer the rest. We applied this approach to estimate parameters in three biological systems: response to heat shock and response to DNA damage in bacteria, and calcium homeostasis in mammals.
format	article
author	Pablo Szekely Hila Sheftel Avi Mayo Uri Alon
author_facet	Pablo Szekely Hila Sheftel Avi Mayo Uri Alon
author_sort	Pablo Szekely
title	Evolutionary tradeoffs between economy and effectiveness in biological homeostasis systems.
title_short	Evolutionary tradeoffs between economy and effectiveness in biological homeostasis systems.
title_full	Evolutionary tradeoffs between economy and effectiveness in biological homeostasis systems.
title_fullStr	Evolutionary tradeoffs between economy and effectiveness in biological homeostasis systems.
title_full_unstemmed	Evolutionary tradeoffs between economy and effectiveness in biological homeostasis systems.
title_sort	evolutionary tradeoffs between economy and effectiveness in biological homeostasis systems.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/3270d86ec45a4b049ae8a4589677f192
work_keys_str_mv	AT pabloszekely evolutionarytradeoffsbetweeneconomyandeffectivenessinbiologicalhomeostasissystems AT hilasheftel evolutionarytradeoffsbetweeneconomyandeffectivenessinbiologicalhomeostasissystems AT avimayo evolutionarytradeoffsbetweeneconomyandeffectivenessinbiologicalhomeostasissystems AT urialon evolutionarytradeoffsbetweeneconomyandeffectivenessinbiologicalhomeostasissystems
_version_	1718424656890822656

Evolutionary tradeoffs between economy and effectiveness in biological homeostasis systems.

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