Optogenetic gamma stimulation rescues memory impairments in an Alzheimer’s disease mouse model

Slow gamma oscillations are associated with memory and have been reported to be disrupted in patients with Alzheimer’s disease. Here the authors show that optogenetic stimulation of medial septum parvalbumin neurons at 40 Hz rescues memory retrieval in the J20 mouse model of Alzheimer’s disease....

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Autores principales: Guillaume Etter, Suzanne van der Veldt, Frédéric Manseau, Iman Zarrinkoub, Emilie Trillaud-Doppia, Sylvain Williams
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/3270dffe391f4bc484b5cf2e0d525297
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Sumario:Slow gamma oscillations are associated with memory and have been reported to be disrupted in patients with Alzheimer’s disease. Here the authors show that optogenetic stimulation of medial septum parvalbumin neurons at 40 Hz rescues memory retrieval in the J20 mouse model of Alzheimer’s disease.