Optogenetic gamma stimulation rescues memory impairments in an Alzheimer’s disease mouse model

Slow gamma oscillations are associated with memory and have been reported to be disrupted in patients with Alzheimer’s disease. Here the authors show that optogenetic stimulation of medial septum parvalbumin neurons at 40 Hz rescues memory retrieval in the J20 mouse model of Alzheimer’s disease....

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Guillaume Etter, Suzanne van der Veldt, Frédéric Manseau, Iman Zarrinkoub, Emilie Trillaud-Doppia, Sylvain Williams
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3270dffe391f4bc484b5cf2e0d525297
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:3270dffe391f4bc484b5cf2e0d525297
record_format	dspace
spelling	oai:doaj.org-article:3270dffe391f4bc484b5cf2e0d5252972021-12-02T17:32:10ZOptogenetic gamma stimulation rescues memory impairments in an Alzheimer’s disease mouse model10.1038/s41467-019-13260-92041-1723https://doaj.org/article/3270dffe391f4bc484b5cf2e0d5252972019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13260-9https://doaj.org/toc/2041-1723Slow gamma oscillations are associated with memory and have been reported to be disrupted in patients with Alzheimer’s disease. Here the authors show that optogenetic stimulation of medial septum parvalbumin neurons at 40 Hz rescues memory retrieval in the J20 mouse model of Alzheimer’s disease.Guillaume EtterSuzanne van der VeldtFrédéric ManseauIman ZarrinkoubEmilie Trillaud-DoppiaSylvain WilliamsNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Guillaume Etter Suzanne van der Veldt Frédéric Manseau Iman Zarrinkoub Emilie Trillaud-Doppia Sylvain Williams Optogenetic gamma stimulation rescues memory impairments in an Alzheimer’s disease mouse model
description	Slow gamma oscillations are associated with memory and have been reported to be disrupted in patients with Alzheimer’s disease. Here the authors show that optogenetic stimulation of medial septum parvalbumin neurons at 40 Hz rescues memory retrieval in the J20 mouse model of Alzheimer’s disease.
format	article
author	Guillaume Etter Suzanne van der Veldt Frédéric Manseau Iman Zarrinkoub Emilie Trillaud-Doppia Sylvain Williams
author_facet	Guillaume Etter Suzanne van der Veldt Frédéric Manseau Iman Zarrinkoub Emilie Trillaud-Doppia Sylvain Williams
author_sort	Guillaume Etter
title	Optogenetic gamma stimulation rescues memory impairments in an Alzheimer’s disease mouse model
title_short	Optogenetic gamma stimulation rescues memory impairments in an Alzheimer’s disease mouse model
title_full	Optogenetic gamma stimulation rescues memory impairments in an Alzheimer’s disease mouse model
title_fullStr	Optogenetic gamma stimulation rescues memory impairments in an Alzheimer’s disease mouse model
title_full_unstemmed	Optogenetic gamma stimulation rescues memory impairments in an Alzheimer’s disease mouse model
title_sort	optogenetic gamma stimulation rescues memory impairments in an alzheimer’s disease mouse model
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/3270dffe391f4bc484b5cf2e0d525297
work_keys_str_mv	AT guillaumeetter optogeneticgammastimulationrescuesmemoryimpairmentsinanalzheimersdiseasemousemodel AT suzannevanderveldt optogeneticgammastimulationrescuesmemoryimpairmentsinanalzheimersdiseasemousemodel AT fredericmanseau optogeneticgammastimulationrescuesmemoryimpairmentsinanalzheimersdiseasemousemodel AT imanzarrinkoub optogeneticgammastimulationrescuesmemoryimpairmentsinanalzheimersdiseasemousemodel AT emilietrillauddoppia optogeneticgammastimulationrescuesmemoryimpairmentsinanalzheimersdiseasemousemodel AT sylvainwilliams optogeneticgammastimulationrescuesmemoryimpairmentsinanalzheimersdiseasemousemodel
_version_	1718380359896268800

Optogenetic gamma stimulation rescues memory impairments in an Alzheimer’s disease mouse model

Ejemplares similares