NATURAL KILLER T CELLS IN HEPATIC LEUCOCYTE INFILTRATES IN PATIENTS WITH MALIGNANT PROCESS AND VIRAL HEPATITIS

Morphology, topography, and immunohistochemical features of leukocyte infiltrates were studied in various sites of the liver samples from the patients with metastatic disease, been affected by hepatitis B and C viruses at different degree of activity. Liver of СВА mice with implanted САО-1 tumour wa...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	O. V. Lebedinskaya, I. N. Kabanovskaja, N. K. Akhmatova, E. A. Lebedinskaya, A. V. Lazareva, M. V. Kiselevsky
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	natural killers natural t-killer cells liver leicocyte infiltrates tumor process viral hepatitis Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/327112bbeb5a40aeaa1dad3f7ff5182b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:327112bbeb5a40aeaa1dad3f7ff5182b
record_format	dspace
spelling	oai:doaj.org-article:327112bbeb5a40aeaa1dad3f7ff5182b2021-11-18T08:03:37ZNATURAL KILLER T CELLS IN HEPATIC LEUCOCYTE INFILTRATES IN PATIENTS WITH MALIGNANT PROCESS AND VIRAL HEPATITIS1563-06252313-741X10.15789/1563-0625-2010-1-2-20-40https://doaj.org/article/327112bbeb5a40aeaa1dad3f7ff5182b2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/38https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XMorphology, topography, and immunohistochemical features of leukocyte infiltrates were studied in various sites of the liver samples from the patients with metastatic disease, been affected by hepatitis B and C viruses at different degree of activity. Liver of СВА mice with implanted САО-1 tumour was also under study. Histochemical, and functional features, as well as immune phenotype of these cells were investigated. It has been shown that the major fraction of leukocyte infiltrates, mostly associated with implanted tumours in experimental mice, and in the areas adjacent to the tumor in humans, like as on the peak of viral hepatitis activity, is composed of lymphocytes. They are presented by large numvers of activated proliferating and differentiating cells bearing specific antigens, as well as natural killers and T-lymphocytes, possessing high-level killer activity towards NK-sensitive, and autologous lines of cancer cells. Hence, the results of our study, generally, confirm the data from literature reporting on existence of a special lymphocyte subpopulation, NKT cells, in human or murine liver affected by hepatitis virus or malignant tumors. The data concerning functional properties of these cells may be used for development of immunotherapy methods of viral diseases and oncological conditions complicated by liver metastases.O. V. LebedinskayaI. N. KabanovskajaN. K. AkhmatovaE. A. LebedinskayaA. V. LazarevaM. V. KiselevskySPb RAACIarticlenatural killersnatural t-killer cellsliverleicocyte infiltratestumor processviral hepatitisImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 12, Iss 1-2, Pp 20-40 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	natural killers natural t-killer cells liver leicocyte infiltrates tumor process viral hepatitis Immunologic diseases. Allergy RC581-607
spellingShingle	natural killers natural t-killer cells liver leicocyte infiltrates tumor process viral hepatitis Immunologic diseases. Allergy RC581-607 O. V. Lebedinskaya I. N. Kabanovskaja N. K. Akhmatova E. A. Lebedinskaya A. V. Lazareva M. V. Kiselevsky NATURAL KILLER T CELLS IN HEPATIC LEUCOCYTE INFILTRATES IN PATIENTS WITH MALIGNANT PROCESS AND VIRAL HEPATITIS
description	Morphology, topography, and immunohistochemical features of leukocyte infiltrates were studied in various sites of the liver samples from the patients with metastatic disease, been affected by hepatitis B and C viruses at different degree of activity. Liver of СВА mice with implanted САО-1 tumour was also under study. Histochemical, and functional features, as well as immune phenotype of these cells were investigated. It has been shown that the major fraction of leukocyte infiltrates, mostly associated with implanted tumours in experimental mice, and in the areas adjacent to the tumor in humans, like as on the peak of viral hepatitis activity, is composed of lymphocytes. They are presented by large numvers of activated proliferating and differentiating cells bearing specific antigens, as well as natural killers and T-lymphocytes, possessing high-level killer activity towards NK-sensitive, and autologous lines of cancer cells. Hence, the results of our study, generally, confirm the data from literature reporting on existence of a special lymphocyte subpopulation, NKT cells, in human or murine liver affected by hepatitis virus or malignant tumors. The data concerning functional properties of these cells may be used for development of immunotherapy methods of viral diseases and oncological conditions complicated by liver metastases.
format	article
author	O. V. Lebedinskaya I. N. Kabanovskaja N. K. Akhmatova E. A. Lebedinskaya A. V. Lazareva M. V. Kiselevsky
author_facet	O. V. Lebedinskaya I. N. Kabanovskaja N. K. Akhmatova E. A. Lebedinskaya A. V. Lazareva M. V. Kiselevsky
author_sort	O. V. Lebedinskaya
title	NATURAL KILLER T CELLS IN HEPATIC LEUCOCYTE INFILTRATES IN PATIENTS WITH MALIGNANT PROCESS AND VIRAL HEPATITIS
title_short	NATURAL KILLER T CELLS IN HEPATIC LEUCOCYTE INFILTRATES IN PATIENTS WITH MALIGNANT PROCESS AND VIRAL HEPATITIS
title_full	NATURAL KILLER T CELLS IN HEPATIC LEUCOCYTE INFILTRATES IN PATIENTS WITH MALIGNANT PROCESS AND VIRAL HEPATITIS
title_fullStr	NATURAL KILLER T CELLS IN HEPATIC LEUCOCYTE INFILTRATES IN PATIENTS WITH MALIGNANT PROCESS AND VIRAL HEPATITIS
title_full_unstemmed	NATURAL KILLER T CELLS IN HEPATIC LEUCOCYTE INFILTRATES IN PATIENTS WITH MALIGNANT PROCESS AND VIRAL HEPATITIS
title_sort	natural killer t cells in hepatic leucocyte infiltrates in patients with malignant process and viral hepatitis
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/327112bbeb5a40aeaa1dad3f7ff5182b
work_keys_str_mv	AT ovlebedinskaya naturalkillertcellsinhepaticleucocyteinfiltratesinpatientswithmalignantprocessandviralhepatitis AT inkabanovskaja naturalkillertcellsinhepaticleucocyteinfiltratesinpatientswithmalignantprocessandviralhepatitis AT nkakhmatova naturalkillertcellsinhepaticleucocyteinfiltratesinpatientswithmalignantprocessandviralhepatitis AT ealebedinskaya naturalkillertcellsinhepaticleucocyteinfiltratesinpatientswithmalignantprocessandviralhepatitis AT avlazareva naturalkillertcellsinhepaticleucocyteinfiltratesinpatientswithmalignantprocessandviralhepatitis AT mvkiselevsky naturalkillertcellsinhepaticleucocyteinfiltratesinpatientswithmalignantprocessandviralhepatitis
_version_	1718422534210191360

NATURAL KILLER T CELLS IN HEPATIC LEUCOCYTE INFILTRATES IN PATIENTS WITH MALIGNANT PROCESS AND VIRAL HEPATITIS

Ejemplares similares