Composition of carbopol 940 and HPMC affects antibacterial activity of beluntas (Pluchea indica (L.)) leaves extract gel

Indonesia is a country known for its source of biological wealth, one of which is beluntas leaves. Beluntas leaves have the potential to be an antibacterial, so it is appropriate to be formulated in the form of medicinal preparations, especially gels. This study aims to find out the influence of var...

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Autores principales:	Fitra Alvionida, Nanik Sulistyani, Nining Sugihartini
Formato:	article
Lenguaje:	EN
Publicado:	Universitas Ahmad Dahlan 2021
Materias:	antibacterial formulation gel pluchea indica (l.) pseudomonas aeruginosa staphylococcus aureus Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/32725bf658bb4213a9d237d05f07ccb5
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spelling	oai:doaj.org-article:32725bf658bb4213a9d237d05f07ccb52021-11-18T01:10:39ZComposition of carbopol 940 and HPMC affects antibacterial activity of beluntas (Pluchea indica (L.)) leaves extract gel10.12928/pharmaciana.v11i3.200172088-45592477-0256https://doaj.org/article/32725bf658bb4213a9d237d05f07ccb52021-11-01T00:00:00Zhttp://journal.uad.ac.id/index.php/PHARMACIANA/article/view/20017/pdf_214https://doaj.org/toc/2088-4559https://doaj.org/toc/2477-0256Indonesia is a country known for its source of biological wealth, one of which is beluntas leaves. Beluntas leaves have the potential to be an antibacterial, so it is appropriate to be formulated in the form of medicinal preparations, especially gels. This study aims to find out the influence of variations between carbopol gel base 940 and hydroxypropyl methylcellulose (HPMC) on the physical properties of gel preparations beluntas leaf extract (Pluchea indica (L.), and know the influence of gel of extract of beluntas leaves on antibacterial activity. The extract is obtained by the maceration method using ethanol solvent 96%. Each formula uses 15% of the extract of beluntas leaves. Gels are made in four gel base variations namely F0 (0.5% carbopol, 1% HPMC), FI (1% carbopol, 1.5% HPMC), FII (1.5% carbopol, 2.5% HPMC), and FIII (2% carbopol, 3% HPMC). Gels evaluated for their physical properties include organoleptic, viscosity, pH, homogeneity, scattering power, adhesion and Freeze-thaw cycling. Then the gel tested antibacterial activity against bacteria Staphylococcus aureus and Pseudomonas aeruginosa by cup-plate diffusion method. The data obtained were analyzed with One Way Anova and LSD with a 95% confidence level. The results showed that beluntas leaf extract gel meets the organoleptic requirements, homogeneity, good gel adhesion (> 4sec), good gel viscosity (2000-50.000 cps), and good gel pH (4.5-6.5). However, the gel does not meet the requirements of good scattering power (5-7 cm) and Freeze-thaw cycling. Based on the test results that have been done with some of the parameters above, The best composition of carbopol 940 and HPMC in the beluntas leaf extract gel which has antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa is 1% carbopol and 1.5% HPMC. The antibacterial activity of the formula is categorized as strong.Fitra AlvionidaNanik Sulistyani Nining SugihartiniUniversitas Ahmad Dahlanarticleantibacterialformulationgelpluchea indica (l.)pseudomonas aeruginosastaphylococcus aureusPharmacy and materia medicaRS1-441ENPharmaciana, Vol 11, Iss 3, Pp 427-438 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	antibacterial formulation gel pluchea indica (l.) pseudomonas aeruginosa staphylococcus aureus Pharmacy and materia medica RS1-441
spellingShingle	antibacterial formulation gel pluchea indica (l.) pseudomonas aeruginosa staphylococcus aureus Pharmacy and materia medica RS1-441 Fitra Alvionida Nanik Sulistyani Nining Sugihartini Composition of carbopol 940 and HPMC affects antibacterial activity of beluntas (Pluchea indica (L.)) leaves extract gel
description	Indonesia is a country known for its source of biological wealth, one of which is beluntas leaves. Beluntas leaves have the potential to be an antibacterial, so it is appropriate to be formulated in the form of medicinal preparations, especially gels. This study aims to find out the influence of variations between carbopol gel base 940 and hydroxypropyl methylcellulose (HPMC) on the physical properties of gel preparations beluntas leaf extract (Pluchea indica (L.), and know the influence of gel of extract of beluntas leaves on antibacterial activity. The extract is obtained by the maceration method using ethanol solvent 96%. Each formula uses 15% of the extract of beluntas leaves. Gels are made in four gel base variations namely F0 (0.5% carbopol, 1% HPMC), FI (1% carbopol, 1.5% HPMC), FII (1.5% carbopol, 2.5% HPMC), and FIII (2% carbopol, 3% HPMC). Gels evaluated for their physical properties include organoleptic, viscosity, pH, homogeneity, scattering power, adhesion and Freeze-thaw cycling. Then the gel tested antibacterial activity against bacteria Staphylococcus aureus and Pseudomonas aeruginosa by cup-plate diffusion method. The data obtained were analyzed with One Way Anova and LSD with a 95% confidence level. The results showed that beluntas leaf extract gel meets the organoleptic requirements, homogeneity, good gel adhesion (> 4sec), good gel viscosity (2000-50.000 cps), and good gel pH (4.5-6.5). However, the gel does not meet the requirements of good scattering power (5-7 cm) and Freeze-thaw cycling. Based on the test results that have been done with some of the parameters above, The best composition of carbopol 940 and HPMC in the beluntas leaf extract gel which has antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa is 1% carbopol and 1.5% HPMC. The antibacterial activity of the formula is categorized as strong.
format	article
author	Fitra Alvionida Nanik Sulistyani Nining Sugihartini
author_facet	Fitra Alvionida Nanik Sulistyani Nining Sugihartini
author_sort	Fitra Alvionida
title	Composition of carbopol 940 and HPMC affects antibacterial activity of beluntas (Pluchea indica (L.)) leaves extract gel
title_short	Composition of carbopol 940 and HPMC affects antibacterial activity of beluntas (Pluchea indica (L.)) leaves extract gel
title_full	Composition of carbopol 940 and HPMC affects antibacterial activity of beluntas (Pluchea indica (L.)) leaves extract gel
title_fullStr	Composition of carbopol 940 and HPMC affects antibacterial activity of beluntas (Pluchea indica (L.)) leaves extract gel
title_full_unstemmed	Composition of carbopol 940 and HPMC affects antibacterial activity of beluntas (Pluchea indica (L.)) leaves extract gel
title_sort	composition of carbopol 940 and hpmc affects antibacterial activity of beluntas (pluchea indica (l.)) leaves extract gel
publisher	Universitas Ahmad Dahlan
publishDate	2021
url	https://doaj.org/article/32725bf658bb4213a9d237d05f07ccb5
work_keys_str_mv	AT fitraalvionida compositionofcarbopol940andhpmcaffectsantibacterialactivityofbeluntasplucheaindicalleavesextractgel AT naniksulistyani compositionofcarbopol940andhpmcaffectsantibacterialactivityofbeluntasplucheaindicalleavesextractgel AT niningsugihartini compositionofcarbopol940andhpmcaffectsantibacterialactivityofbeluntasplucheaindicalleavesextractgel
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Composition of carbopol 940 and HPMC affects antibacterial activity of beluntas (Pluchea indica (L.)) leaves extract gel

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