Prognostic value of histological response to chemotherapy in osteosarcoma patients receiving tumor-bearing frozen autograft.

<h4>Background</h4>A variety of surgical procedures are now available for tissue reconstruction after osteosarcoma excision, and an important prognostic factor is the evaluation of response to chemotherapy using histology. Although tumor-bearing autografts are useful tools for reconstruc...

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Autores principales: Shinji Miwa, Akihiko Takeuchi, Hiroko Ikeda, Toshiharu Shirai, Norio Yamamoto, Hideji Nishida, Katsuhiro Hayashi, Yoshikazu Tanzawa, Hiroaki Kimura, Kentaro Igarashi, Hiroyuki Tsuchiya
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Publicado: Public Library of Science (PLoS) 2013
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spelling oai:doaj.org-article:3272db1bb23247d586c1dcb748b76fa12021-11-18T08:59:26ZPrognostic value of histological response to chemotherapy in osteosarcoma patients receiving tumor-bearing frozen autograft.1932-620310.1371/journal.pone.0071362https://doaj.org/article/3272db1bb23247d586c1dcb748b76fa12013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23977028/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>A variety of surgical procedures are now available for tissue reconstruction after osteosarcoma excision, and an important prognostic factor is the evaluation of response to chemotherapy using histology. Although tumor-bearing autografts are useful tools for reconstruction, re-use of the primary tumor may make it difficult to assess the histological response to chemotherapy, since the entire tumor cannot be analyzed. Here, we analyzed the prognostic value of the histological response in the patients who received frozen tumor-bearing autografts for reconstruction.<h4>Method</h4>Retrospective analysis of the medical records of 51 patients with high-grade osteosarcoma of the extremities was performed. All patients received reconstruction using frozen tumor-bearing autografts. Tumor necrosis was evaluated in extraskeletal masses and cancellous bone.<h4>Results</h4>Five-year overall survival of patients with good and poor response to chemotherapy was 82.9% and 46.4%, respectively (P = 0.044), and 5-year event-free survival was 57.7% and 36.0%, respectively (P = 0.329). Multivariate analysis revealed that a poor histological response to chemotherapy was a significant prognostic factor for overall survival (P = 0.033).<h4>Conclusion</h4>Histological response is an important and reliable prognostic factor in patients undergoing reconstruction using frozen tumor-bearing autografts.Shinji MiwaAkihiko TakeuchiHiroko IkedaToshiharu ShiraiNorio YamamotoHideji NishidaKatsuhiro HayashiYoshikazu TanzawaHiroaki KimuraKentaro IgarashiHiroyuki TsuchiyaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 8, p e71362 (2013)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Shinji Miwa
Akihiko Takeuchi
Hiroko Ikeda
Toshiharu Shirai
Norio Yamamoto
Hideji Nishida
Katsuhiro Hayashi
Yoshikazu Tanzawa
Hiroaki Kimura
Kentaro Igarashi
Hiroyuki Tsuchiya
Prognostic value of histological response to chemotherapy in osteosarcoma patients receiving tumor-bearing frozen autograft.
description <h4>Background</h4>A variety of surgical procedures are now available for tissue reconstruction after osteosarcoma excision, and an important prognostic factor is the evaluation of response to chemotherapy using histology. Although tumor-bearing autografts are useful tools for reconstruction, re-use of the primary tumor may make it difficult to assess the histological response to chemotherapy, since the entire tumor cannot be analyzed. Here, we analyzed the prognostic value of the histological response in the patients who received frozen tumor-bearing autografts for reconstruction.<h4>Method</h4>Retrospective analysis of the medical records of 51 patients with high-grade osteosarcoma of the extremities was performed. All patients received reconstruction using frozen tumor-bearing autografts. Tumor necrosis was evaluated in extraskeletal masses and cancellous bone.<h4>Results</h4>Five-year overall survival of patients with good and poor response to chemotherapy was 82.9% and 46.4%, respectively (P = 0.044), and 5-year event-free survival was 57.7% and 36.0%, respectively (P = 0.329). Multivariate analysis revealed that a poor histological response to chemotherapy was a significant prognostic factor for overall survival (P = 0.033).<h4>Conclusion</h4>Histological response is an important and reliable prognostic factor in patients undergoing reconstruction using frozen tumor-bearing autografts.
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author Shinji Miwa
Akihiko Takeuchi
Hiroko Ikeda
Toshiharu Shirai
Norio Yamamoto
Hideji Nishida
Katsuhiro Hayashi
Yoshikazu Tanzawa
Hiroaki Kimura
Kentaro Igarashi
Hiroyuki Tsuchiya
author_facet Shinji Miwa
Akihiko Takeuchi
Hiroko Ikeda
Toshiharu Shirai
Norio Yamamoto
Hideji Nishida
Katsuhiro Hayashi
Yoshikazu Tanzawa
Hiroaki Kimura
Kentaro Igarashi
Hiroyuki Tsuchiya
author_sort Shinji Miwa
title Prognostic value of histological response to chemotherapy in osteosarcoma patients receiving tumor-bearing frozen autograft.
title_short Prognostic value of histological response to chemotherapy in osteosarcoma patients receiving tumor-bearing frozen autograft.
title_full Prognostic value of histological response to chemotherapy in osteosarcoma patients receiving tumor-bearing frozen autograft.
title_fullStr Prognostic value of histological response to chemotherapy in osteosarcoma patients receiving tumor-bearing frozen autograft.
title_full_unstemmed Prognostic value of histological response to chemotherapy in osteosarcoma patients receiving tumor-bearing frozen autograft.
title_sort prognostic value of histological response to chemotherapy in osteosarcoma patients receiving tumor-bearing frozen autograft.
publisher Public Library of Science (PLoS)
publishDate 2013
url https://doaj.org/article/3272db1bb23247d586c1dcb748b76fa1
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