Activation of parabrachial nucleus - ventral tegmental area pathway underlies the comorbid depression in chronic neuropathic pain in mice

Summary: Depression symptoms are often found in patients suffering from chronic pain, a phenomenon that is yet to be understood mechanistically. Here, we systematically investigate the cellular mechanisms and circuits underlying the chronic-pain-induced depression behavior. We show that the developm...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ludi Zhang, Jing Wang, Chenxu Niu, Yu Zhang, Tiantian Zhu, Dongyang Huang, Jing Ma, Hui Sun, Nikita Gamper, Xiaona Du, Hailin Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/3273da8010dd4b809206e648b6f33a46
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:3273da8010dd4b809206e648b6f33a46
record_format	dspace
spelling	oai:doaj.org-article:3273da8010dd4b809206e648b6f33a462021-11-04T04:29:25ZActivation of parabrachial nucleus - ventral tegmental area pathway underlies the comorbid depression in chronic neuropathic pain in mice2211-124710.1016/j.celrep.2021.109936https://doaj.org/article/3273da8010dd4b809206e648b6f33a462021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2211124721014091https://doaj.org/toc/2211-1247Summary: Depression symptoms are often found in patients suffering from chronic pain, a phenomenon that is yet to be understood mechanistically. Here, we systematically investigate the cellular mechanisms and circuits underlying the chronic-pain-induced depression behavior. We show that the development of chronic pain is accompanied by depressive-like behaviors in a mouse model of trigeminal neuralgia. In parallel, we observe increased activity of the dopaminergic (DA) neuron in the midbrain ventral tegmental area (VTA), and inhibition of this elevated VTA DA neuron activity reverses the behavioral manifestations of depression. Further studies establish a pathway of glutamatergic projections from the spinal trigeminal subnucleus caudalis (Sp5C) to the lateral parabrachial nucleus (LPBN) and then to the VTA. These glutamatergic projections form a direct circuit that controls the development of the depression-like behavior under the state of the chronic neuropathic pain.Ludi ZhangJing WangChenxu NiuYu ZhangTiantian ZhuDongyang HuangJing MaHui SunNikita GamperXiaona DuHailin ZhangElsevierarticleBiology (General)QH301-705.5ENCell Reports, Vol 37, Iss 5, Pp 109936- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Ludi Zhang Jing Wang Chenxu Niu Yu Zhang Tiantian Zhu Dongyang Huang Jing Ma Hui Sun Nikita Gamper Xiaona Du Hailin Zhang Activation of parabrachial nucleus - ventral tegmental area pathway underlies the comorbid depression in chronic neuropathic pain in mice
description	Summary: Depression symptoms are often found in patients suffering from chronic pain, a phenomenon that is yet to be understood mechanistically. Here, we systematically investigate the cellular mechanisms and circuits underlying the chronic-pain-induced depression behavior. We show that the development of chronic pain is accompanied by depressive-like behaviors in a mouse model of trigeminal neuralgia. In parallel, we observe increased activity of the dopaminergic (DA) neuron in the midbrain ventral tegmental area (VTA), and inhibition of this elevated VTA DA neuron activity reverses the behavioral manifestations of depression. Further studies establish a pathway of glutamatergic projections from the spinal trigeminal subnucleus caudalis (Sp5C) to the lateral parabrachial nucleus (LPBN) and then to the VTA. These glutamatergic projections form a direct circuit that controls the development of the depression-like behavior under the state of the chronic neuropathic pain.
format	article
author	Ludi Zhang Jing Wang Chenxu Niu Yu Zhang Tiantian Zhu Dongyang Huang Jing Ma Hui Sun Nikita Gamper Xiaona Du Hailin Zhang
author_facet	Ludi Zhang Jing Wang Chenxu Niu Yu Zhang Tiantian Zhu Dongyang Huang Jing Ma Hui Sun Nikita Gamper Xiaona Du Hailin Zhang
author_sort	Ludi Zhang
title	Activation of parabrachial nucleus - ventral tegmental area pathway underlies the comorbid depression in chronic neuropathic pain in mice
title_short	Activation of parabrachial nucleus - ventral tegmental area pathway underlies the comorbid depression in chronic neuropathic pain in mice
title_full	Activation of parabrachial nucleus - ventral tegmental area pathway underlies the comorbid depression in chronic neuropathic pain in mice
title_fullStr	Activation of parabrachial nucleus - ventral tegmental area pathway underlies the comorbid depression in chronic neuropathic pain in mice
title_full_unstemmed	Activation of parabrachial nucleus - ventral tegmental area pathway underlies the comorbid depression in chronic neuropathic pain in mice
title_sort	activation of parabrachial nucleus - ventral tegmental area pathway underlies the comorbid depression in chronic neuropathic pain in mice
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/3273da8010dd4b809206e648b6f33a46
work_keys_str_mv	AT ludizhang activationofparabrachialnucleusventraltegmentalareapathwayunderliesthecomorbiddepressioninchronicneuropathicpaininmice AT jingwang activationofparabrachialnucleusventraltegmentalareapathwayunderliesthecomorbiddepressioninchronicneuropathicpaininmice AT chenxuniu activationofparabrachialnucleusventraltegmentalareapathwayunderliesthecomorbiddepressioninchronicneuropathicpaininmice AT yuzhang activationofparabrachialnucleusventraltegmentalareapathwayunderliesthecomorbiddepressioninchronicneuropathicpaininmice AT tiantianzhu activationofparabrachialnucleusventraltegmentalareapathwayunderliesthecomorbiddepressioninchronicneuropathicpaininmice AT dongyanghuang activationofparabrachialnucleusventraltegmentalareapathwayunderliesthecomorbiddepressioninchronicneuropathicpaininmice AT jingma activationofparabrachialnucleusventraltegmentalareapathwayunderliesthecomorbiddepressioninchronicneuropathicpaininmice AT huisun activationofparabrachialnucleusventraltegmentalareapathwayunderliesthecomorbiddepressioninchronicneuropathicpaininmice AT nikitagamper activationofparabrachialnucleusventraltegmentalareapathwayunderliesthecomorbiddepressioninchronicneuropathicpaininmice AT xiaonadu activationofparabrachialnucleusventraltegmentalareapathwayunderliesthecomorbiddepressioninchronicneuropathicpaininmice AT hailinzhang activationofparabrachialnucleusventraltegmentalareapathwayunderliesthecomorbiddepressioninchronicneuropathicpaininmice
_version_	1718445266459164672

Activation of parabrachial nucleus - ventral tegmental area pathway underlies the comorbid depression in chronic neuropathic pain in mice

Ejemplares similares