HD Physiology Project—Japanese efforts to promote multilevel integrative systems biology and physiome research

Abstract The HD Physiology Project is a Japanese research consortium that aimed to develop methods and a computational platform in which physiological and pathological information can be described in high-level definitions across multiple scales of time and size. During the 5 years of this project,...

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Autores principales:	Kazuharu Furutani, Kunichika Tsumoto, Yoshihisa Kurachi, for HD physiology project investigators
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/32749499b1454f07b3e40ab76fdeecb7
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spelling	oai:doaj.org-article:32749499b1454f07b3e40ab76fdeecb72021-12-02T12:33:54ZHD Physiology Project—Japanese efforts to promote multilevel integrative systems biology and physiome research10.1038/s41540-016-0001-02056-7189https://doaj.org/article/32749499b1454f07b3e40ab76fdeecb72017-01-01T00:00:00Zhttps://doi.org/10.1038/s41540-016-0001-0https://doaj.org/toc/2056-7189Abstract The HD Physiology Project is a Japanese research consortium that aimed to develop methods and a computational platform in which physiological and pathological information can be described in high-level definitions across multiple scales of time and size. During the 5 years of this project, an appropriate software platform for multilevel functional simulation was developed and a whole-heart model including pharmacokinetics for the assessment of the proarrhythmic risk of drugs was developed. In this article, we outline the description and scientific strategy of this project and present the achievements and influence on multilevel integrative systems biology and physiome research.Kazuharu FurutaniKunichika TsumotoYoshihisa Kurachifor HD physiology project investigatorsNature PortfolioarticleBiology (General)QH301-705.5ENnpj Systems Biology and Applications, Vol 3, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Kazuharu Furutani Kunichika Tsumoto Yoshihisa Kurachi for HD physiology project investigators HD Physiology Project—Japanese efforts to promote multilevel integrative systems biology and physiome research
description	Abstract The HD Physiology Project is a Japanese research consortium that aimed to develop methods and a computational platform in which physiological and pathological information can be described in high-level definitions across multiple scales of time and size. During the 5 years of this project, an appropriate software platform for multilevel functional simulation was developed and a whole-heart model including pharmacokinetics for the assessment of the proarrhythmic risk of drugs was developed. In this article, we outline the description and scientific strategy of this project and present the achievements and influence on multilevel integrative systems biology and physiome research.
format	article
author	Kazuharu Furutani Kunichika Tsumoto Yoshihisa Kurachi for HD physiology project investigators
author_facet	Kazuharu Furutani Kunichika Tsumoto Yoshihisa Kurachi for HD physiology project investigators
author_sort	Kazuharu Furutani
title	HD Physiology Project—Japanese efforts to promote multilevel integrative systems biology and physiome research
title_short	HD Physiology Project—Japanese efforts to promote multilevel integrative systems biology and physiome research
title_full	HD Physiology Project—Japanese efforts to promote multilevel integrative systems biology and physiome research
title_fullStr	HD Physiology Project—Japanese efforts to promote multilevel integrative systems biology and physiome research
title_full_unstemmed	HD Physiology Project—Japanese efforts to promote multilevel integrative systems biology and physiome research
title_sort	hd physiology project—japanese efforts to promote multilevel integrative systems biology and physiome research
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/32749499b1454f07b3e40ab76fdeecb7
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HD Physiology Project—Japanese efforts to promote multilevel integrative systems biology and physiome research

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