Acquired olfactory loss alters functional connectivity and morphology

Abstract Removing function from a developed and functional sensory system is known to alter both cerebral morphology and functional connections. To date, a majority of studies assessing sensory-dependent plasticity have focused on effects from either early onset or long-term sensory loss and little...

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Autores principales:	Behzad Iravani, Moa G. Peter, Artin Arshamian, Mats J. Olsson, Thomas Hummel, Hagen H. Kitzler, Johan N. Lundström
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3274afc5f0914bfc8c69989f5f77d135
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spelling	oai:doaj.org-article:3274afc5f0914bfc8c69989f5f77d1352021-12-02T18:50:53ZAcquired olfactory loss alters functional connectivity and morphology10.1038/s41598-021-95968-72045-2322https://doaj.org/article/3274afc5f0914bfc8c69989f5f77d1352021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95968-7https://doaj.org/toc/2045-2322Abstract Removing function from a developed and functional sensory system is known to alter both cerebral morphology and functional connections. To date, a majority of studies assessing sensory-dependent plasticity have focused on effects from either early onset or long-term sensory loss and little is known how the recent sensory loss affects the human brain. With the aim of determining how recent sensory loss affects cerebral morphology and functional connectivity, we assessed differences between individuals with acquired olfactory loss (duration 7–36 months) and matched healthy controls in their grey matter volume, using multivariate pattern analyses, and functional connectivity, using dynamic connectivity analyses, within and from the olfactory cortex. Our results demonstrate that acquired olfactory loss is associated with altered grey matter volume in, among others, posterior piriform cortex, a core olfactory processing area, as well as the inferior frontal gyrus and angular gyrus. In addition, compared to controls, individuals with acquired anosmia displayed significantly stronger dynamic functional connectivity from the posterior piriform cortex to, among others, the angular gyrus, a known multisensory integration area. When assessing differences in dynamic functional connectivity from the angular gyrus, individuals with acquired anosmia had stronger connectivity from the angular gyrus to areas primary responsible for basic visual processing. These results demonstrate that recently acquired sensory loss is associated with both changed cerebral morphology within core olfactory areas and increase dynamic functional connectivity from olfactory cortex to cerebral areas processing multisensory integration.Behzad IravaniMoa G. PeterArtin ArshamianMats J. OlssonThomas HummelHagen H. KitzlerJohan N. LundströmNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Behzad Iravani Moa G. Peter Artin Arshamian Mats J. Olsson Thomas Hummel Hagen H. Kitzler Johan N. Lundström Acquired olfactory loss alters functional connectivity and morphology
description	Abstract Removing function from a developed and functional sensory system is known to alter both cerebral morphology and functional connections. To date, a majority of studies assessing sensory-dependent plasticity have focused on effects from either early onset or long-term sensory loss and little is known how the recent sensory loss affects the human brain. With the aim of determining how recent sensory loss affects cerebral morphology and functional connectivity, we assessed differences between individuals with acquired olfactory loss (duration 7–36 months) and matched healthy controls in their grey matter volume, using multivariate pattern analyses, and functional connectivity, using dynamic connectivity analyses, within and from the olfactory cortex. Our results demonstrate that acquired olfactory loss is associated with altered grey matter volume in, among others, posterior piriform cortex, a core olfactory processing area, as well as the inferior frontal gyrus and angular gyrus. In addition, compared to controls, individuals with acquired anosmia displayed significantly stronger dynamic functional connectivity from the posterior piriform cortex to, among others, the angular gyrus, a known multisensory integration area. When assessing differences in dynamic functional connectivity from the angular gyrus, individuals with acquired anosmia had stronger connectivity from the angular gyrus to areas primary responsible for basic visual processing. These results demonstrate that recently acquired sensory loss is associated with both changed cerebral morphology within core olfactory areas and increase dynamic functional connectivity from olfactory cortex to cerebral areas processing multisensory integration.
format	article
author	Behzad Iravani Moa G. Peter Artin Arshamian Mats J. Olsson Thomas Hummel Hagen H. Kitzler Johan N. Lundström
author_facet	Behzad Iravani Moa G. Peter Artin Arshamian Mats J. Olsson Thomas Hummel Hagen H. Kitzler Johan N. Lundström
author_sort	Behzad Iravani
title	Acquired olfactory loss alters functional connectivity and morphology
title_short	Acquired olfactory loss alters functional connectivity and morphology
title_full	Acquired olfactory loss alters functional connectivity and morphology
title_fullStr	Acquired olfactory loss alters functional connectivity and morphology
title_full_unstemmed	Acquired olfactory loss alters functional connectivity and morphology
title_sort	acquired olfactory loss alters functional connectivity and morphology
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3274afc5f0914bfc8c69989f5f77d135
work_keys_str_mv	AT behzadiravani acquiredolfactorylossaltersfunctionalconnectivityandmorphology AT moagpeter acquiredolfactorylossaltersfunctionalconnectivityandmorphology AT artinarshamian acquiredolfactorylossaltersfunctionalconnectivityandmorphology AT matsjolsson acquiredolfactorylossaltersfunctionalconnectivityandmorphology AT thomashummel acquiredolfactorylossaltersfunctionalconnectivityandmorphology AT hagenhkitzler acquiredolfactorylossaltersfunctionalconnectivityandmorphology AT johannlundstrom acquiredolfactorylossaltersfunctionalconnectivityandmorphology
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Acquired olfactory loss alters functional connectivity and morphology

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