Gingivitis and salivary immunoglobulins in patients with Thalassemia major

Background and Objective: The defensive role of saliva is mainly played via immunoglobulins. Periodontal infections are the most common diseases in oral cavity and therefore defensive function of saliva against these infections are important. With regard to the effects of systemic diseases on defens...

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Autores principales:	M Motaleb Nejad, N Jenabian, A Mostapha Zadeh, N Afshari
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2002
Materias:	thalassemia major saliva immunoglobulins gingivitis Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/3277517942fd435ead77a186841dbbb9
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spelling	oai:doaj.org-article:3277517942fd435ead77a186841dbbb92021-11-10T09:19:31ZGingivitis and salivary immunoglobulins in patients with Thalassemia major1561-41072251-7170https://doaj.org/article/3277517942fd435ead77a186841dbbb92002-04-01T00:00:00Zhttp://jbums.org/article-1-2827-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170Background and Objective: The defensive role of saliva is mainly played via immunoglobulins. Periodontal infections are the most common diseases in oral cavity and therefore defensive function of saliva against these infections are important. With regard to the effects of systemic diseases on defensive function of saliva, the objective of this study was to survey the relationship between gingivitis and salivary immunoglobulins in patients with Thalassemia major. Methods: This study was done on 55 children (Between 5-12 years old) with Thalassemia major who referred to Thalassemia center of Amirkola children hospital. Of these, 30 cases with gingivitis and 25 without gingivitis were chosen as case and control groups, respectively. Questionnaires were prepared and then evaluation of gingiva condition was done. Saliva samples were taken and examined by ELISA. Findings: There was no significant difference between the rate of IgA, IgG and IgM in two groups. Also, there was not relationship between severity of gingivitis and the rate of salivary immunoglobulins. Conclusion: T-cells affect on the activity of B cells. With regard to reduction of activity of T-cells lymphocyte (CD4) in Thalassemia and the effect of these cells on promotion of B-lymphocyte function, B-cells not response to gingivitis by synthesis of immunoglobulins.M Motaleb NejadN JenabianA Mostapha ZadehN AfshariBabol University of Medical Sciencesarticlethalassemia majorsalivaimmunoglobulinsgingivitisMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 4, Iss 2, Pp 7-12 (2002)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	thalassemia major saliva immunoglobulins gingivitis Medicine R Medicine (General) R5-920
spellingShingle	thalassemia major saliva immunoglobulins gingivitis Medicine R Medicine (General) R5-920 M Motaleb Nejad N Jenabian A Mostapha Zadeh N Afshari Gingivitis and salivary immunoglobulins in patients with Thalassemia major
description	Background and Objective: The defensive role of saliva is mainly played via immunoglobulins. Periodontal infections are the most common diseases in oral cavity and therefore defensive function of saliva against these infections are important. With regard to the effects of systemic diseases on defensive function of saliva, the objective of this study was to survey the relationship between gingivitis and salivary immunoglobulins in patients with Thalassemia major. Methods: This study was done on 55 children (Between 5-12 years old) with Thalassemia major who referred to Thalassemia center of Amirkola children hospital. Of these, 30 cases with gingivitis and 25 without gingivitis were chosen as case and control groups, respectively. Questionnaires were prepared and then evaluation of gingiva condition was done. Saliva samples were taken and examined by ELISA. Findings: There was no significant difference between the rate of IgA, IgG and IgM in two groups. Also, there was not relationship between severity of gingivitis and the rate of salivary immunoglobulins. Conclusion: T-cells affect on the activity of B cells. With regard to reduction of activity of T-cells lymphocyte (CD4) in Thalassemia and the effect of these cells on promotion of B-lymphocyte function, B-cells not response to gingivitis by synthesis of immunoglobulins.
format	article
author	M Motaleb Nejad N Jenabian A Mostapha Zadeh N Afshari
author_facet	M Motaleb Nejad N Jenabian A Mostapha Zadeh N Afshari
author_sort	M Motaleb Nejad
title	Gingivitis and salivary immunoglobulins in patients with Thalassemia major
title_short	Gingivitis and salivary immunoglobulins in patients with Thalassemia major
title_full	Gingivitis and salivary immunoglobulins in patients with Thalassemia major
title_fullStr	Gingivitis and salivary immunoglobulins in patients with Thalassemia major
title_full_unstemmed	Gingivitis and salivary immunoglobulins in patients with Thalassemia major
title_sort	gingivitis and salivary immunoglobulins in patients with thalassemia major
publisher	Babol University of Medical Sciences
publishDate	2002
url	https://doaj.org/article/3277517942fd435ead77a186841dbbb9
work_keys_str_mv	AT mmotalebnejad gingivitisandsalivaryimmunoglobulinsinpatientswiththalassemiamajor AT njenabian gingivitisandsalivaryimmunoglobulinsinpatientswiththalassemiamajor AT amostaphazadeh gingivitisandsalivaryimmunoglobulinsinpatientswiththalassemiamajor AT nafshari gingivitisandsalivaryimmunoglobulinsinpatientswiththalassemiamajor
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Gingivitis and salivary immunoglobulins in patients with Thalassemia major

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