Pericyte FAK negatively regulates Gas6/Axl signalling to suppress tumour angiogenesis and tumour growth

Focal adhesion kinase (FAK) is required for tumour angiogenesis and growth. Here, the authors show that deletion of pericyte FAK upregulates Gas6-Axl mediated Cyr61 production, which increases endothelial cell proliferation and angiogenesis, while elevating tissue factor production to enhance tumour...

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Autores principales:	Tanguy Lechertier, Louise E. Reynolds, Hyojin Kim, Ana Rita Pedrosa, Jesús Gómez-Escudero, José M. Muñoz-Félix, Silvia Batista, Matthew Dukinfield, Fevzi Demircioglu, Ping Pui Wong, Kylie P. Matchett, Neil C. Henderson, Gabriela D’Amico, Maddy Parsons, Catherine Harwood, Pascal Meier, Kairbaan M. Hodivala-Dilke
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/327b0c1e155a4263840ab94acda7cb38
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spelling	oai:doaj.org-article:327b0c1e155a4263840ab94acda7cb382021-12-02T15:56:54ZPericyte FAK negatively regulates Gas6/Axl signalling to suppress tumour angiogenesis and tumour growth10.1038/s41467-020-16618-62041-1723https://doaj.org/article/327b0c1e155a4263840ab94acda7cb382020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16618-6https://doaj.org/toc/2041-1723Focal adhesion kinase (FAK) is required for tumour angiogenesis and growth. Here, the authors show that deletion of pericyte FAK upregulates Gas6-Axl mediated Cyr61 production, which increases endothelial cell proliferation and angiogenesis, while elevating tissue factor production to enhance tumour cell proliferation.Tanguy LechertierLouise E. ReynoldsHyojin KimAna Rita PedrosaJesús Gómez-EscuderoJosé M. Muñoz-FélixSilvia BatistaMatthew DukinfieldFevzi DemirciogluPing Pui WongKylie P. MatchettNeil C. HendersonGabriela D’AmicoMaddy ParsonsCatherine HarwoodPascal MeierKairbaan M. Hodivala-DilkeNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tanguy Lechertier Louise E. Reynolds Hyojin Kim Ana Rita Pedrosa Jesús Gómez-Escudero José M. Muñoz-Félix Silvia Batista Matthew Dukinfield Fevzi Demircioglu Ping Pui Wong Kylie P. Matchett Neil C. Henderson Gabriela D’Amico Maddy Parsons Catherine Harwood Pascal Meier Kairbaan M. Hodivala-Dilke Pericyte FAK negatively regulates Gas6/Axl signalling to suppress tumour angiogenesis and tumour growth
description	Focal adhesion kinase (FAK) is required for tumour angiogenesis and growth. Here, the authors show that deletion of pericyte FAK upregulates Gas6-Axl mediated Cyr61 production, which increases endothelial cell proliferation and angiogenesis, while elevating tissue factor production to enhance tumour cell proliferation.
format	article
author	Tanguy Lechertier Louise E. Reynolds Hyojin Kim Ana Rita Pedrosa Jesús Gómez-Escudero José M. Muñoz-Félix Silvia Batista Matthew Dukinfield Fevzi Demircioglu Ping Pui Wong Kylie P. Matchett Neil C. Henderson Gabriela D’Amico Maddy Parsons Catherine Harwood Pascal Meier Kairbaan M. Hodivala-Dilke
author_facet	Tanguy Lechertier Louise E. Reynolds Hyojin Kim Ana Rita Pedrosa Jesús Gómez-Escudero José M. Muñoz-Félix Silvia Batista Matthew Dukinfield Fevzi Demircioglu Ping Pui Wong Kylie P. Matchett Neil C. Henderson Gabriela D’Amico Maddy Parsons Catherine Harwood Pascal Meier Kairbaan M. Hodivala-Dilke
author_sort	Tanguy Lechertier
title	Pericyte FAK negatively regulates Gas6/Axl signalling to suppress tumour angiogenesis and tumour growth
title_short	Pericyte FAK negatively regulates Gas6/Axl signalling to suppress tumour angiogenesis and tumour growth
title_full	Pericyte FAK negatively regulates Gas6/Axl signalling to suppress tumour angiogenesis and tumour growth
title_fullStr	Pericyte FAK negatively regulates Gas6/Axl signalling to suppress tumour angiogenesis and tumour growth
title_full_unstemmed	Pericyte FAK negatively regulates Gas6/Axl signalling to suppress tumour angiogenesis and tumour growth
title_sort	pericyte fak negatively regulates gas6/axl signalling to suppress tumour angiogenesis and tumour growth
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/327b0c1e155a4263840ab94acda7cb38
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Pericyte FAK negatively regulates Gas6/Axl signalling to suppress tumour angiogenesis and tumour growth

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