Pericyte FAK negatively regulates Gas6/Axl signalling to suppress tumour angiogenesis and tumour growth
Focal adhesion kinase (FAK) is required for tumour angiogenesis and growth. Here, the authors show that deletion of pericyte FAK upregulates Gas6-Axl mediated Cyr61 production, which increases endothelial cell proliferation and angiogenesis, while elevating tissue factor production to enhance tumour...
Guardado en:
Autores principales: | Tanguy Lechertier, Louise E. Reynolds, Hyojin Kim, Ana Rita Pedrosa, Jesús Gómez-Escudero, José M. Muñoz-Félix, Silvia Batista, Matthew Dukinfield, Fevzi Demircioglu, Ping Pui Wong, Kylie P. Matchett, Neil C. Henderson, Gabriela D’Amico, Maddy Parsons, Catherine Harwood, Pascal Meier, Kairbaan M. Hodivala-Dilke |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2020
|
Materias: | |
Acceso en línea: | https://doaj.org/article/327b0c1e155a4263840ab94acda7cb38 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Stromal Claudin14-heterozygosity, but not deletion, increases tumour blood leakage without affecting tumour growth.
por: Marianne Baker, et al.
Publicado: (2013) -
Cancer associated fibroblast FAK regulates malignant cell metabolism
por: Fevzi Demircioglu, et al.
Publicado: (2020) -
The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages
por: Yunlong Yang, et al.
Publicado: (2016) -
Tumour-associated macrophages exhibit anti-tumoural properties in Sonic Hedgehog medulloblastoma
por: Victor Maximov, et al.
Publicado: (2019) -
Pan-cancer analysis of homozygous deletions in primary tumours uncovers rare tumour suppressors
por: Jiqiu Cheng, et al.
Publicado: (2017)