Harnessing a catalytic lysine residue for the one-step preparation of homogeneous antibody-drug conjugates

Current strategies for producing antibody-drug conjugates often rely on inefficient conjugation chemistry or on generating mutations in the antibody sequence. Here the authors demonstrate a mutation-free, single-step conjugation platform utilizing a buried lysine residue.

Guardado en:

Detalles Bibliográficos
Autores principales:	Alex R. Nanna, Xiuling Li, Even Walseng, Lee Pedzisa, Rebecca S. Goydel, David Hymel, Terrence R. Burke Jr., William R. Roush, Christoph Rader
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/327d54533f8140538f895070e14be5c5
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:327d54533f8140538f895070e14be5c5
record_format	dspace
spelling	oai:doaj.org-article:327d54533f8140538f895070e14be5c52021-12-02T15:38:30ZHarnessing a catalytic lysine residue for the one-step preparation of homogeneous antibody-drug conjugates10.1038/s41467-017-01257-12041-1723https://doaj.org/article/327d54533f8140538f895070e14be5c52017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01257-1https://doaj.org/toc/2041-1723Current strategies for producing antibody-drug conjugates often rely on inefficient conjugation chemistry or on generating mutations in the antibody sequence. Here the authors demonstrate a mutation-free, single-step conjugation platform utilizing a buried lysine residue.Alex R. NannaXiuling LiEven WalsengLee PedzisaRebecca S. GoydelDavid HymelTerrence R. Burke Jr.William R. RoushChristoph RaderNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alex R. Nanna Xiuling Li Even Walseng Lee Pedzisa Rebecca S. Goydel David Hymel Terrence R. Burke Jr. William R. Roush Christoph Rader Harnessing a catalytic lysine residue for the one-step preparation of homogeneous antibody-drug conjugates
description	Current strategies for producing antibody-drug conjugates often rely on inefficient conjugation chemistry or on generating mutations in the antibody sequence. Here the authors demonstrate a mutation-free, single-step conjugation platform utilizing a buried lysine residue.
format	article
author	Alex R. Nanna Xiuling Li Even Walseng Lee Pedzisa Rebecca S. Goydel David Hymel Terrence R. Burke Jr. William R. Roush Christoph Rader
author_facet	Alex R. Nanna Xiuling Li Even Walseng Lee Pedzisa Rebecca S. Goydel David Hymel Terrence R. Burke Jr. William R. Roush Christoph Rader
author_sort	Alex R. Nanna
title	Harnessing a catalytic lysine residue for the one-step preparation of homogeneous antibody-drug conjugates
title_short	Harnessing a catalytic lysine residue for the one-step preparation of homogeneous antibody-drug conjugates
title_full	Harnessing a catalytic lysine residue for the one-step preparation of homogeneous antibody-drug conjugates
title_fullStr	Harnessing a catalytic lysine residue for the one-step preparation of homogeneous antibody-drug conjugates
title_full_unstemmed	Harnessing a catalytic lysine residue for the one-step preparation of homogeneous antibody-drug conjugates
title_sort	harnessing a catalytic lysine residue for the one-step preparation of homogeneous antibody-drug conjugates
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/327d54533f8140538f895070e14be5c5
work_keys_str_mv	AT alexrnanna harnessingacatalyticlysineresiduefortheonesteppreparationofhomogeneousantibodydrugconjugates AT xiulingli harnessingacatalyticlysineresiduefortheonesteppreparationofhomogeneousantibodydrugconjugates AT evenwalseng harnessingacatalyticlysineresiduefortheonesteppreparationofhomogeneousantibodydrugconjugates AT leepedzisa harnessingacatalyticlysineresiduefortheonesteppreparationofhomogeneousantibodydrugconjugates AT rebeccasgoydel harnessingacatalyticlysineresiduefortheonesteppreparationofhomogeneousantibodydrugconjugates AT davidhymel harnessingacatalyticlysineresiduefortheonesteppreparationofhomogeneousantibodydrugconjugates AT terrencerburkejr harnessingacatalyticlysineresiduefortheonesteppreparationofhomogeneousantibodydrugconjugates AT williamrroush harnessingacatalyticlysineresiduefortheonesteppreparationofhomogeneousantibodydrugconjugates AT christophrader harnessingacatalyticlysineresiduefortheonesteppreparationofhomogeneousantibodydrugconjugates
_version_	1718386164090535936

Harnessing a catalytic lysine residue for the one-step preparation of homogeneous antibody-drug conjugates

Ejemplares similares