Activation of LXRα improves cardiac remodeling induced by pulmonary artery hypertension in rats

Abstract Inflammatory factors regulated by NF-κB play a significant role in PAH and myocardial hypertrophy. LXR activation may inhibit myocardial hypertrophy via suppressing inflammatory pathways; it is unknown whether LXR is also involved in PAH-induced myocardial hypertrophy or remodeling. To furt...

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Autores principales:	Yibo Gong, Yifeng Yang, Qin Wu, Ge Gao, Yin Liu, Yaoyao Xiong, Can Huang, Sijie Wu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/327d5ef72998436da400ac45e5e076fc
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spelling	oai:doaj.org-article:327d5ef72998436da400ac45e5e076fc2021-12-02T15:06:08ZActivation of LXRα improves cardiac remodeling induced by pulmonary artery hypertension in rats10.1038/s41598-017-04640-62045-2322https://doaj.org/article/327d5ef72998436da400ac45e5e076fc2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04640-6https://doaj.org/toc/2045-2322Abstract Inflammatory factors regulated by NF-κB play a significant role in PAH and myocardial hypertrophy. LXR activation may inhibit myocardial hypertrophy via suppressing inflammatory pathways; it is unknown whether LXR is also involved in PAH-induced myocardial hypertrophy or remodeling. To further explore the protective effect of LXR in PAH-induced cardiac hypertrophy and remodeling, a PAH model was developed, and T0901317, an agonist of LXR, was used to examine the effect of LXR activation. PAH rats demonstrated obvious cardiac hypertrophy and remodeling in the right ventricle, but significant improvement of cardiac hypertrophy and remodeling was observed in PAH rats treated with T0901317. Through RT-PCR, Western blot and ELISA examination, NF-κB, IL-6, TNF-α, and iNOS were found to be significantly reduced in PAH rats treated with T0901317 compared to PAH rats treated with DMSO. Apoptosis was also significantly reduced in PAH rats treated with T0901317. Thus, LXR activation may inhibit PAH-induced cardiac hypertrophy and remodeling by inhibiting NF-κB-mediated inflammatory pathways.Yibo GongYifeng YangQin WuGe GaoYin LiuYaoyao XiongCan HuangSijie WuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yibo Gong Yifeng Yang Qin Wu Ge Gao Yin Liu Yaoyao Xiong Can Huang Sijie Wu Activation of LXRα improves cardiac remodeling induced by pulmonary artery hypertension in rats
description	Abstract Inflammatory factors regulated by NF-κB play a significant role in PAH and myocardial hypertrophy. LXR activation may inhibit myocardial hypertrophy via suppressing inflammatory pathways; it is unknown whether LXR is also involved in PAH-induced myocardial hypertrophy or remodeling. To further explore the protective effect of LXR in PAH-induced cardiac hypertrophy and remodeling, a PAH model was developed, and T0901317, an agonist of LXR, was used to examine the effect of LXR activation. PAH rats demonstrated obvious cardiac hypertrophy and remodeling in the right ventricle, but significant improvement of cardiac hypertrophy and remodeling was observed in PAH rats treated with T0901317. Through RT-PCR, Western blot and ELISA examination, NF-κB, IL-6, TNF-α, and iNOS were found to be significantly reduced in PAH rats treated with T0901317 compared to PAH rats treated with DMSO. Apoptosis was also significantly reduced in PAH rats treated with T0901317. Thus, LXR activation may inhibit PAH-induced cardiac hypertrophy and remodeling by inhibiting NF-κB-mediated inflammatory pathways.
format	article
author	Yibo Gong Yifeng Yang Qin Wu Ge Gao Yin Liu Yaoyao Xiong Can Huang Sijie Wu
author_facet	Yibo Gong Yifeng Yang Qin Wu Ge Gao Yin Liu Yaoyao Xiong Can Huang Sijie Wu
author_sort	Yibo Gong
title	Activation of LXRα improves cardiac remodeling induced by pulmonary artery hypertension in rats
title_short	Activation of LXRα improves cardiac remodeling induced by pulmonary artery hypertension in rats
title_full	Activation of LXRα improves cardiac remodeling induced by pulmonary artery hypertension in rats
title_fullStr	Activation of LXRα improves cardiac remodeling induced by pulmonary artery hypertension in rats
title_full_unstemmed	Activation of LXRα improves cardiac remodeling induced by pulmonary artery hypertension in rats
title_sort	activation of lxrα improves cardiac remodeling induced by pulmonary artery hypertension in rats
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/327d5ef72998436da400ac45e5e076fc
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_version_	1718388572284780544

Activation of LXRα improves cardiac remodeling induced by pulmonary artery hypertension in rats

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