Morphologic determinant of tight junctions revealed by claudin-3 structures

The main components of tight junctions (TJ) are claudins that polymerize and form meshwork architectures called TJ strands. Here the authors present the 3.6 Å crystal structure of murine claudin-3 and show that residue P134 causes a bending of the third transmembrane helix which affects the morpholo...

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Autores principales:	Shun Nakamura, Katsumasa Irie, Hiroo Tanaka, Kouki Nishikawa, Hiroshi Suzuki, Yasunori Saitoh, Atsushi Tamura, Sachiko Tsukita, Yoshinori Fujiyoshi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3282587ab8ef40f0a71dedabefc971b9
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spelling	oai:doaj.org-article:3282587ab8ef40f0a71dedabefc971b92021-12-02T17:32:23ZMorphologic determinant of tight junctions revealed by claudin-3 structures10.1038/s41467-019-08760-72041-1723https://doaj.org/article/3282587ab8ef40f0a71dedabefc971b92019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08760-7https://doaj.org/toc/2041-1723The main components of tight junctions (TJ) are claudins that polymerize and form meshwork architectures called TJ strands. Here the authors present the 3.6 Å crystal structure of murine claudin-3 and show that residue P134 causes a bending of the third transmembrane helix which affects the morphology and adhesiveness of the TJ strands.Shun NakamuraKatsumasa IrieHiroo TanakaKouki NishikawaHiroshi SuzukiYasunori SaitohAtsushi TamuraSachiko TsukitaYoshinori FujiyoshiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shun Nakamura Katsumasa Irie Hiroo Tanaka Kouki Nishikawa Hiroshi Suzuki Yasunori Saitoh Atsushi Tamura Sachiko Tsukita Yoshinori Fujiyoshi Morphologic determinant of tight junctions revealed by claudin-3 structures
description	The main components of tight junctions (TJ) are claudins that polymerize and form meshwork architectures called TJ strands. Here the authors present the 3.6 Å crystal structure of murine claudin-3 and show that residue P134 causes a bending of the third transmembrane helix which affects the morphology and adhesiveness of the TJ strands.
format	article
author	Shun Nakamura Katsumasa Irie Hiroo Tanaka Kouki Nishikawa Hiroshi Suzuki Yasunori Saitoh Atsushi Tamura Sachiko Tsukita Yoshinori Fujiyoshi
author_facet	Shun Nakamura Katsumasa Irie Hiroo Tanaka Kouki Nishikawa Hiroshi Suzuki Yasunori Saitoh Atsushi Tamura Sachiko Tsukita Yoshinori Fujiyoshi
author_sort	Shun Nakamura
title	Morphologic determinant of tight junctions revealed by claudin-3 structures
title_short	Morphologic determinant of tight junctions revealed by claudin-3 structures
title_full	Morphologic determinant of tight junctions revealed by claudin-3 structures
title_fullStr	Morphologic determinant of tight junctions revealed by claudin-3 structures
title_full_unstemmed	Morphologic determinant of tight junctions revealed by claudin-3 structures
title_sort	morphologic determinant of tight junctions revealed by claudin-3 structures
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/3282587ab8ef40f0a71dedabefc971b9
work_keys_str_mv	AT shunnakamura morphologicdeterminantoftightjunctionsrevealedbyclaudin3structures AT katsumasairie morphologicdeterminantoftightjunctionsrevealedbyclaudin3structures AT hirootanaka morphologicdeterminantoftightjunctionsrevealedbyclaudin3structures AT koukinishikawa morphologicdeterminantoftightjunctionsrevealedbyclaudin3structures AT hiroshisuzuki morphologicdeterminantoftightjunctionsrevealedbyclaudin3structures AT yasunorisaitoh morphologicdeterminantoftightjunctionsrevealedbyclaudin3structures AT atsushitamura morphologicdeterminantoftightjunctionsrevealedbyclaudin3structures AT sachikotsukita morphologicdeterminantoftightjunctionsrevealedbyclaudin3structures AT yoshinorifujiyoshi morphologicdeterminantoftightjunctionsrevealedbyclaudin3structures
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Morphologic determinant of tight junctions revealed by claudin-3 structures

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