Role of cross-cleft contacts in NMDA receptor gating.

In response to brief glutamate exposure, NMDA receptors produce excitatory currents that have sub-maximal amplitudes and characteristically slow kinetics. The activation sequence starts when glutamate binds to residues located on the upper lobe of extracellularly located ligand-binding domains (LBDs...

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Autores principales: Meaghan A Paganelli, Cassandra L Kussius, Gabriela K Popescu
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
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Acceso en línea:https://doaj.org/article/32838e0657084d0e85616958e8679ebc
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