Fungal volatile compounds induce production of the secondary metabolite Sodorifen in Serratia plymuthica PRI-2C

Abstract The ability of bacteria and fungi to communicate with each other is a remarkable aspect of the microbial world. It is recognized that volatile organic compounds (VOCs) act as communication signals, however the molecular responses by bacteria to fungal VOCs remain unknown. Here we perform tr...

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Autores principales:	Ruth Schmidt, Victor de Jager, Daniela Zühlke, Christian Wolff, Jörg Bernhardt, Katarina Cankar, Jules Beekwilder, Wilfred van Ijcken, Frank Sleutels, Wietse de Boer, Katharina Riedel, Paolina Garbeva
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/328958306bbd42f4838ad9d6933250b7
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spelling	oai:doaj.org-article:328958306bbd42f4838ad9d6933250b72021-12-02T16:08:22ZFungal volatile compounds induce production of the secondary metabolite Sodorifen in Serratia plymuthica PRI-2C10.1038/s41598-017-00893-32045-2322https://doaj.org/article/328958306bbd42f4838ad9d6933250b72017-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00893-3https://doaj.org/toc/2045-2322Abstract The ability of bacteria and fungi to communicate with each other is a remarkable aspect of the microbial world. It is recognized that volatile organic compounds (VOCs) act as communication signals, however the molecular responses by bacteria to fungal VOCs remain unknown. Here we perform transcriptomics and proteomics analyses of Serratia plymuthica PRI-2C exposed to VOCs emitted by the fungal pathogen Fusarium culmorum. We find that the bacterium responds to fungal VOCs with changes in gene and protein expression related to motility, signal transduction, energy metabolism, cell envelope biogenesis, and secondary metabolite production. Metabolomic analysis of the bacterium exposed to the fungal VOCs, gene cluster comparison, and heterologous co-expression of a terpene synthase and a methyltransferase revealed the production of the unusual terpene sodorifen in response to fungal VOCs. These results strongly suggest that VOCs are not only a metabolic waste but important compounds in the long-distance communication between fungi and bacteria.Ruth SchmidtVictor de JagerDaniela ZühlkeChristian WolffJörg BernhardtKatarina CankarJules BeekwilderWilfred van IjckenFrank SleutelsWietse de BoerKatharina RiedelPaolina GarbevaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ruth Schmidt Victor de Jager Daniela Zühlke Christian Wolff Jörg Bernhardt Katarina Cankar Jules Beekwilder Wilfred van Ijcken Frank Sleutels Wietse de Boer Katharina Riedel Paolina Garbeva Fungal volatile compounds induce production of the secondary metabolite Sodorifen in Serratia plymuthica PRI-2C
description	Abstract The ability of bacteria and fungi to communicate with each other is a remarkable aspect of the microbial world. It is recognized that volatile organic compounds (VOCs) act as communication signals, however the molecular responses by bacteria to fungal VOCs remain unknown. Here we perform transcriptomics and proteomics analyses of Serratia plymuthica PRI-2C exposed to VOCs emitted by the fungal pathogen Fusarium culmorum. We find that the bacterium responds to fungal VOCs with changes in gene and protein expression related to motility, signal transduction, energy metabolism, cell envelope biogenesis, and secondary metabolite production. Metabolomic analysis of the bacterium exposed to the fungal VOCs, gene cluster comparison, and heterologous co-expression of a terpene synthase and a methyltransferase revealed the production of the unusual terpene sodorifen in response to fungal VOCs. These results strongly suggest that VOCs are not only a metabolic waste but important compounds in the long-distance communication between fungi and bacteria.
format	article
author	Ruth Schmidt Victor de Jager Daniela Zühlke Christian Wolff Jörg Bernhardt Katarina Cankar Jules Beekwilder Wilfred van Ijcken Frank Sleutels Wietse de Boer Katharina Riedel Paolina Garbeva
author_facet	Ruth Schmidt Victor de Jager Daniela Zühlke Christian Wolff Jörg Bernhardt Katarina Cankar Jules Beekwilder Wilfred van Ijcken Frank Sleutels Wietse de Boer Katharina Riedel Paolina Garbeva
author_sort	Ruth Schmidt
title	Fungal volatile compounds induce production of the secondary metabolite Sodorifen in Serratia plymuthica PRI-2C
title_short	Fungal volatile compounds induce production of the secondary metabolite Sodorifen in Serratia plymuthica PRI-2C
title_full	Fungal volatile compounds induce production of the secondary metabolite Sodorifen in Serratia plymuthica PRI-2C
title_fullStr	Fungal volatile compounds induce production of the secondary metabolite Sodorifen in Serratia plymuthica PRI-2C
title_full_unstemmed	Fungal volatile compounds induce production of the secondary metabolite Sodorifen in Serratia plymuthica PRI-2C
title_sort	fungal volatile compounds induce production of the secondary metabolite sodorifen in serratia plymuthica pri-2c
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/328958306bbd42f4838ad9d6933250b7
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Fungal volatile compounds induce production of the secondary metabolite Sodorifen in Serratia plymuthica PRI-2C

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