The mitochondrial genome, a growing interest inside an organelle

Marco Crimi1, Roberta Rigolio21National Institute of Molecular Genetics (INGM), Functional Genomics Unit, Milan, Italy; 2Department of Neurosciences and Biomedical Technologies, University of Milan Bicocca, Monza, ItalyAbstract: Mitochondria are semi-autonomously reproductive organelles within eukar...

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Autores principales:	Marco Crimi, Roberta Rigolio
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/328a6cbaae9940bd87d8a4941e3fb91c
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spelling	oai:doaj.org-article:328a6cbaae9940bd87d8a4941e3fb91c2021-12-02T06:32:00ZThe mitochondrial genome, a growing interest inside an organelle1176-91141178-2013https://doaj.org/article/328a6cbaae9940bd87d8a4941e3fb91c2008-03-01T00:00:00Zhttp://www.dovepress.com/the-mitochondrial-genome-a-growing-interest-inside-an-organelle-a734https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Marco Crimi1, Roberta Rigolio21National Institute of Molecular Genetics (INGM), Functional Genomics Unit, Milan, Italy; 2Department of Neurosciences and Biomedical Technologies, University of Milan Bicocca, Monza, ItalyAbstract: Mitochondria are semi-autonomously reproductive organelles within eukaryotic cells carrying their own genetic material, called the mitochondrial genome (mtDNA). Until some years ago, mtDNA had primarily been used as a tool in population genetics. As scientists began associating mtDNA mutations with dozens of mysterious disorders, as well as the aging process and a variety of chronic degenerative diseases, it became increasingly evident that the information contained in this genome had substantial potential applications to improve human health. Today, mitochondria research covers a wide range of disciplines, including clinical medicine, biochemistry, genetics, molecular cell biology, bioinformatics, plant sciences and physiology. The present review intends to present a summary of the most exiting fields of the mitochondrial research bringing together several contributes in terms of original prospective and future applications.Keywords: mtDNA, heteroplasmy, molecular diagnostics, mitochondriopathies, nanogenomics Marco CrimiRoberta RigolioDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2008, Iss Issue 1, Pp 51-57 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Marco Crimi Roberta Rigolio The mitochondrial genome, a growing interest inside an organelle
description	Marco Crimi1, Roberta Rigolio21National Institute of Molecular Genetics (INGM), Functional Genomics Unit, Milan, Italy; 2Department of Neurosciences and Biomedical Technologies, University of Milan Bicocca, Monza, ItalyAbstract: Mitochondria are semi-autonomously reproductive organelles within eukaryotic cells carrying their own genetic material, called the mitochondrial genome (mtDNA). Until some years ago, mtDNA had primarily been used as a tool in population genetics. As scientists began associating mtDNA mutations with dozens of mysterious disorders, as well as the aging process and a variety of chronic degenerative diseases, it became increasingly evident that the information contained in this genome had substantial potential applications to improve human health. Today, mitochondria research covers a wide range of disciplines, including clinical medicine, biochemistry, genetics, molecular cell biology, bioinformatics, plant sciences and physiology. The present review intends to present a summary of the most exiting fields of the mitochondrial research bringing together several contributes in terms of original prospective and future applications.Keywords: mtDNA, heteroplasmy, molecular diagnostics, mitochondriopathies, nanogenomics
format	article
author	Marco Crimi Roberta Rigolio
author_facet	Marco Crimi Roberta Rigolio
author_sort	Marco Crimi
title	The mitochondrial genome, a growing interest inside an organelle
title_short	The mitochondrial genome, a growing interest inside an organelle
title_full	The mitochondrial genome, a growing interest inside an organelle
title_fullStr	The mitochondrial genome, a growing interest inside an organelle
title_full_unstemmed	The mitochondrial genome, a growing interest inside an organelle
title_sort	mitochondrial genome, a growing interest inside an organelle
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/328a6cbaae9940bd87d8a4941e3fb91c
work_keys_str_mv	AT marcocrimi themitochondrialgenomeagrowinginterestinsideanorganelle AT robertarigolio themitochondrialgenomeagrowinginterestinsideanorganelle AT marcocrimi mitochondrialgenomeagrowinginterestinsideanorganelle AT robertarigolio mitochondrialgenomeagrowinginterestinsideanorganelle
_version_	1718399865814253568

The mitochondrial genome, a growing interest inside an organelle

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