PLGA Coatings and PLGA Drug-Loading Coatings for Cardiac Stent Samples: Degradation Characteristics and Blood Compatibility

PLGA (Poly lactic-co-glycolic acid) and PLGA drug-loading coatings were prepared on 316 L stainless steel by electrostatic spray deposition (ESD). The surface morphology, three-dimensional morphology, and crystal structures of the coatings were observed by scanning electron microscopy (SEM), atomic...

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Autores principales:	Ziyang Jia, Chunyang Ma, Hongbin Zhang
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	drug-loading coatings preparation characterization blood compatibility Engineering (General). Civil engineering (General) TA1-2040
Acceso en línea:	https://doaj.org/article/328ce5e68ef24f3ea03f5f9592e037d3
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spelling	oai:doaj.org-article:328ce5e68ef24f3ea03f5f9592e037d32021-11-25T17:17:07ZPLGA Coatings and PLGA Drug-Loading Coatings for Cardiac Stent Samples: Degradation Characteristics and Blood Compatibility10.3390/coatings111114272079-6412https://doaj.org/article/328ce5e68ef24f3ea03f5f9592e037d32021-11-01T00:00:00Zhttps://www.mdpi.com/2079-6412/11/11/1427https://doaj.org/toc/2079-6412PLGA (Poly lactic-co-glycolic acid) and PLGA drug-loading coatings were prepared on 316 L stainless steel by electrostatic spray deposition (ESD). The surface morphology, three-dimensional morphology, and crystal structures of the coatings were observed by scanning electron microscopy (SEM), atomic force microscopy (AFM), and X-ray diffraction (XRD). Thermal properties, molecular weight, and coating composition were studied by differential scanning calorimetry (DSC), gel permeation chromatography (GPC), and NMR. The degradation behaviors of the coatings were studied by mass changes, relative molecular mass and distributions, polymer compositions, thermal properties, and surface morphologies. The blood compatibilities of the coatings were investigated by platelet adhesion testing and dynamic coagulation times. SEM results indicated the drug-loading coating with 33% RAPA had the smoothest and most compact morphology. Addition of RAPA decreased the Tg of the PLGA coating, accompanied by partial crystallization that slowed the degradation rate of the drug-loaded coating. Microscopically, the morphology of the PLGA drug-loaded coating was coarser than the PLGA coating. The average surface roughness values of line and surface scannings were 16.232 nm and 39.538 nm, respectively. The surface of the drug-loading coating was micro uneven, and the macro smooth and micro multiphase separation structure helped improve its blood compatibility.Ziyang JiaChunyang MaHongbin ZhangMDPI AGarticledrug-loading coatingspreparationcharacterizationblood compatibilityEngineering (General). Civil engineering (General)TA1-2040ENCoatings, Vol 11, Iss 1427, p 1427 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	drug-loading coatings preparation characterization blood compatibility Engineering (General). Civil engineering (General) TA1-2040
spellingShingle	drug-loading coatings preparation characterization blood compatibility Engineering (General). Civil engineering (General) TA1-2040 Ziyang Jia Chunyang Ma Hongbin Zhang PLGA Coatings and PLGA Drug-Loading Coatings for Cardiac Stent Samples: Degradation Characteristics and Blood Compatibility
description	PLGA (Poly lactic-co-glycolic acid) and PLGA drug-loading coatings were prepared on 316 L stainless steel by electrostatic spray deposition (ESD). The surface morphology, three-dimensional morphology, and crystal structures of the coatings were observed by scanning electron microscopy (SEM), atomic force microscopy (AFM), and X-ray diffraction (XRD). Thermal properties, molecular weight, and coating composition were studied by differential scanning calorimetry (DSC), gel permeation chromatography (GPC), and NMR. The degradation behaviors of the coatings were studied by mass changes, relative molecular mass and distributions, polymer compositions, thermal properties, and surface morphologies. The blood compatibilities of the coatings were investigated by platelet adhesion testing and dynamic coagulation times. SEM results indicated the drug-loading coating with 33% RAPA had the smoothest and most compact morphology. Addition of RAPA decreased the Tg of the PLGA coating, accompanied by partial crystallization that slowed the degradation rate of the drug-loaded coating. Microscopically, the morphology of the PLGA drug-loaded coating was coarser than the PLGA coating. The average surface roughness values of line and surface scannings were 16.232 nm and 39.538 nm, respectively. The surface of the drug-loading coating was micro uneven, and the macro smooth and micro multiphase separation structure helped improve its blood compatibility.
format	article
author	Ziyang Jia Chunyang Ma Hongbin Zhang
author_facet	Ziyang Jia Chunyang Ma Hongbin Zhang
author_sort	Ziyang Jia
title	PLGA Coatings and PLGA Drug-Loading Coatings for Cardiac Stent Samples: Degradation Characteristics and Blood Compatibility
title_short	PLGA Coatings and PLGA Drug-Loading Coatings for Cardiac Stent Samples: Degradation Characteristics and Blood Compatibility
title_full	PLGA Coatings and PLGA Drug-Loading Coatings for Cardiac Stent Samples: Degradation Characteristics and Blood Compatibility
title_fullStr	PLGA Coatings and PLGA Drug-Loading Coatings for Cardiac Stent Samples: Degradation Characteristics and Blood Compatibility
title_full_unstemmed	PLGA Coatings and PLGA Drug-Loading Coatings for Cardiac Stent Samples: Degradation Characteristics and Blood Compatibility
title_sort	plga coatings and plga drug-loading coatings for cardiac stent samples: degradation characteristics and blood compatibility
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/328ce5e68ef24f3ea03f5f9592e037d3
work_keys_str_mv	AT ziyangjia plgacoatingsandplgadrugloadingcoatingsforcardiacstentsamplesdegradationcharacteristicsandbloodcompatibility AT chunyangma plgacoatingsandplgadrugloadingcoatingsforcardiacstentsamplesdegradationcharacteristicsandbloodcompatibility AT hongbinzhang plgacoatingsandplgadrugloadingcoatingsforcardiacstentsamplesdegradationcharacteristicsandbloodcompatibility
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PLGA Coatings and PLGA Drug-Loading Coatings for Cardiac Stent Samples: Degradation Characteristics and Blood Compatibility

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