Location-specific inhibition of Akt reveals regulation of mTORC1 activity in the nucleus

The role of mTORC1 at the lysosome is well established, but mTORC1 is known to be active in other cellular locations. Here, the authors develop Akt-STOPS to inhibit Akt specifically in the nucleus and identify a new regulatory mode for mTORC1 distinct in the nucleus.

Guardado en:

Detalles Bibliográficos
Autores principales:	Xin Zhou, Yanghao Zhong, Olivia Molinar-Inglis, Maya T. Kunkel, Mingyuan Chen, Tengqian Sun, Jiao Zhang, John Y.-J. Shyy, JoAnn Trejo, Alexandra C. Newton, Jin Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/328e1750a1694424bd2ac2b272c85bfe
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:328e1750a1694424bd2ac2b272c85bfe
record_format	dspace
spelling	oai:doaj.org-article:328e1750a1694424bd2ac2b272c85bfe2021-12-02T17:31:54ZLocation-specific inhibition of Akt reveals regulation of mTORC1 activity in the nucleus10.1038/s41467-020-19937-w2041-1723https://doaj.org/article/328e1750a1694424bd2ac2b272c85bfe2020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19937-whttps://doaj.org/toc/2041-1723The role of mTORC1 at the lysosome is well established, but mTORC1 is known to be active in other cellular locations. Here, the authors develop Akt-STOPS to inhibit Akt specifically in the nucleus and identify a new regulatory mode for mTORC1 distinct in the nucleus.Xin ZhouYanghao ZhongOlivia Molinar-InglisMaya T. KunkelMingyuan ChenTengqian SunJiao ZhangJohn Y.-J. ShyyJoAnn TrejoAlexandra C. NewtonJin ZhangNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xin Zhou Yanghao Zhong Olivia Molinar-Inglis Maya T. Kunkel Mingyuan Chen Tengqian Sun Jiao Zhang John Y.-J. Shyy JoAnn Trejo Alexandra C. Newton Jin Zhang Location-specific inhibition of Akt reveals regulation of mTORC1 activity in the nucleus
description	The role of mTORC1 at the lysosome is well established, but mTORC1 is known to be active in other cellular locations. Here, the authors develop Akt-STOPS to inhibit Akt specifically in the nucleus and identify a new regulatory mode for mTORC1 distinct in the nucleus.
format	article
author	Xin Zhou Yanghao Zhong Olivia Molinar-Inglis Maya T. Kunkel Mingyuan Chen Tengqian Sun Jiao Zhang John Y.-J. Shyy JoAnn Trejo Alexandra C. Newton Jin Zhang
author_facet	Xin Zhou Yanghao Zhong Olivia Molinar-Inglis Maya T. Kunkel Mingyuan Chen Tengqian Sun Jiao Zhang John Y.-J. Shyy JoAnn Trejo Alexandra C. Newton Jin Zhang
author_sort	Xin Zhou
title	Location-specific inhibition of Akt reveals regulation of mTORC1 activity in the nucleus
title_short	Location-specific inhibition of Akt reveals regulation of mTORC1 activity in the nucleus
title_full	Location-specific inhibition of Akt reveals regulation of mTORC1 activity in the nucleus
title_fullStr	Location-specific inhibition of Akt reveals regulation of mTORC1 activity in the nucleus
title_full_unstemmed	Location-specific inhibition of Akt reveals regulation of mTORC1 activity in the nucleus
title_sort	location-specific inhibition of akt reveals regulation of mtorc1 activity in the nucleus
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/328e1750a1694424bd2ac2b272c85bfe
work_keys_str_mv	AT xinzhou locationspecificinhibitionofaktrevealsregulationofmtorc1activityinthenucleus AT yanghaozhong locationspecificinhibitionofaktrevealsregulationofmtorc1activityinthenucleus AT oliviamolinaringlis locationspecificinhibitionofaktrevealsregulationofmtorc1activityinthenucleus AT mayatkunkel locationspecificinhibitionofaktrevealsregulationofmtorc1activityinthenucleus AT mingyuanchen locationspecificinhibitionofaktrevealsregulationofmtorc1activityinthenucleus AT tengqiansun locationspecificinhibitionofaktrevealsregulationofmtorc1activityinthenucleus AT jiaozhang locationspecificinhibitionofaktrevealsregulationofmtorc1activityinthenucleus AT johnyjshyy locationspecificinhibitionofaktrevealsregulationofmtorc1activityinthenucleus AT joanntrejo locationspecificinhibitionofaktrevealsregulationofmtorc1activityinthenucleus AT alexandracnewton locationspecificinhibitionofaktrevealsregulationofmtorc1activityinthenucleus AT jinzhang locationspecificinhibitionofaktrevealsregulationofmtorc1activityinthenucleus
_version_	1718380421259984896

Location-specific inhibition of Akt reveals regulation of mTORC1 activity in the nucleus

Ejemplares similares