Mesenteric cryptococcal granuloma in a dog caused by Cryptococcus neoformans var. grubii

Jennifer R Cook, Karen E Russell, Kristin B Eden, Aline Rodrigues-HoffmannDepartment of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A&amp;M University, College Station, TX, USAAbstract: Although cryptococcosis is usually associated with respiratory...

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Autores principales:	Rodrigues-Hoffmann A, Eden KB, Russell KE, Cook JR
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/328ffe37607041b787f00128e65b07ce
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spelling	oai:doaj.org-article:328ffe37607041b787f00128e65b07ce2021-12-02T02:00:17ZMesenteric cryptococcal granuloma in a dog caused by Cryptococcus neoformans var. grubii2230-2034https://doaj.org/article/328ffe37607041b787f00128e65b07ce2012-09-01T00:00:00Zhttp://www.dovepress.com/mesenteric-cryptococcal-granuloma-in-a-dog-caused-by-cryptococcus-neof-a11145https://doaj.org/toc/2230-2034Jennifer R Cook, Karen E Russell, Kristin B Eden, Aline Rodrigues-HoffmannDepartment of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A&amp;M University, College Station, TX, USAAbstract: Although cryptococcosis is usually associated with respiratory and neurologic signs in domestic species (such as sneeze, cough, nasal discharge, seizures, ataxia), clinical manifestations of the disease may be more subtle and nonspecific. A 3-year-old male castrated Boxer dog presented with a history of chronic vomiting, diarrhea, weight loss, and lethargy. At no time had respiratory or neurologic signs been noted by the owners or the primary care veterinarian. Palpation of an abdominal mass revealed an atypical lesion location: a large (16 &times; 9 &times; 7 cm) mass at the root of the mesentery. Diagnosis was achieved through cytology of this mass and a positive serologic Cryptococcus capsular antigen titer; polymerase chain reaction was utilized for speciation of the abdominal isolate as Cryptococcus neoformans variety grubii. The animal was euthanized due to poor prognosis. After necropsy and histopathologic analysis, the mesenteric mass and associated lymph nodes were identified as large fungal granulomas. This is a rare manifestation of cryptococcosis, involving several visceral organs, with no remaining evidence of the route of entry of the organism. As prompt diagnosis of mycotic illness is paramount to successful management, this case indicates that cryptococcal infection should be considered as a differential diagnosis in dogs with gastrointestinal signs and lymphadenopathy. The protean nature of cryptococcosis is discussed within the context of a brief review of emerging and unresolved issues in pathogenesis.Keywords: Cryptococcus gattii, granuloma, lymphadenitisRodrigues-Hoffmann AEden KBRussell KECook JRDove Medical PressarticleVeterinary medicineSF600-1100ENVeterinary Medicine: Research and Reports, Vol 2012, Iss default, Pp 93-98 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Veterinary medicine SF600-1100
spellingShingle	Veterinary medicine SF600-1100 Rodrigues-Hoffmann A Eden KB Russell KE Cook JR Mesenteric cryptococcal granuloma in a dog caused by Cryptococcus neoformans var. grubii
description	Jennifer R Cook, Karen E Russell, Kristin B Eden, Aline Rodrigues-HoffmannDepartment of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A&amp;M University, College Station, TX, USAAbstract: Although cryptococcosis is usually associated with respiratory and neurologic signs in domestic species (such as sneeze, cough, nasal discharge, seizures, ataxia), clinical manifestations of the disease may be more subtle and nonspecific. A 3-year-old male castrated Boxer dog presented with a history of chronic vomiting, diarrhea, weight loss, and lethargy. At no time had respiratory or neurologic signs been noted by the owners or the primary care veterinarian. Palpation of an abdominal mass revealed an atypical lesion location: a large (16 &times; 9 &times; 7 cm) mass at the root of the mesentery. Diagnosis was achieved through cytology of this mass and a positive serologic Cryptococcus capsular antigen titer; polymerase chain reaction was utilized for speciation of the abdominal isolate as Cryptococcus neoformans variety grubii. The animal was euthanized due to poor prognosis. After necropsy and histopathologic analysis, the mesenteric mass and associated lymph nodes were identified as large fungal granulomas. This is a rare manifestation of cryptococcosis, involving several visceral organs, with no remaining evidence of the route of entry of the organism. As prompt diagnosis of mycotic illness is paramount to successful management, this case indicates that cryptococcal infection should be considered as a differential diagnosis in dogs with gastrointestinal signs and lymphadenopathy. The protean nature of cryptococcosis is discussed within the context of a brief review of emerging and unresolved issues in pathogenesis.Keywords: Cryptococcus gattii, granuloma, lymphadenitis
format	article
author	Rodrigues-Hoffmann A Eden KB Russell KE Cook JR
author_facet	Rodrigues-Hoffmann A Eden KB Russell KE Cook JR
author_sort	Rodrigues-Hoffmann A
title	Mesenteric cryptococcal granuloma in a dog caused by Cryptococcus neoformans var. grubii
title_short	Mesenteric cryptococcal granuloma in a dog caused by Cryptococcus neoformans var. grubii
title_full	Mesenteric cryptococcal granuloma in a dog caused by Cryptococcus neoformans var. grubii
title_fullStr	Mesenteric cryptococcal granuloma in a dog caused by Cryptococcus neoformans var. grubii
title_full_unstemmed	Mesenteric cryptococcal granuloma in a dog caused by Cryptococcus neoformans var. grubii
title_sort	mesenteric cryptococcal granuloma in a dog caused by cryptococcus neoformans var. grubii
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/328ffe37607041b787f00128e65b07ce
work_keys_str_mv	AT rodrigueshoffmanna mesentericcryptococcalgranulomainadogcausedbycryptococcusneoformansvargrubii AT edenkb mesentericcryptococcalgranulomainadogcausedbycryptococcusneoformansvargrubii AT russellke mesentericcryptococcalgranulomainadogcausedbycryptococcusneoformansvargrubii AT cookjr mesentericcryptococcalgranulomainadogcausedbycryptococcusneoformansvargrubii
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Mesenteric cryptococcal granuloma in a dog caused by Cryptococcus neoformans var. grubii

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