Sustained co-delivery of ibuprofen and basic fibroblast growth factor by thermosensitive nanoparticle hydrogel as early local treatment of peri-implantitis

Wenlei Chen,1 Min Zhi,1 Zujian Feng,2 Pengfei Gao,1 Yuan Yuan,1 Congcong Zhang,1 Yonglan Wang,1 Anjie Dong2 1Department of Periodontology, School and Hospital of Stomatology, Tianjin Medical University, Tianjin, People’s Republic of China; 2Department of Polymer Science and Technology and...

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Autores principales:	Chen W, Zhi M, Feng Z, Gao P, Yuan Y, Zhang C, Wang Y, Dong A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	thermo-sensitive hydrogel nanoparticles PECT dual drugs peri-implantitis Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/3290110da6b14877a21a6a225921358d
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spelling	oai:doaj.org-article:3290110da6b14877a21a6a225921358d2021-12-02T04:09:36ZSustained co-delivery of ibuprofen and basic fibroblast growth factor by thermosensitive nanoparticle hydrogel as early local treatment of peri-implantitis1178-2013https://doaj.org/article/3290110da6b14877a21a6a225921358d2019-02-01T00:00:00Zhttps://www.dovepress.com/sustained-co-delivery-of-ibuprofen-and-basic-fibroblast-growth-factor--peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Wenlei Chen,1 Min Zhi,1 Zujian Feng,2 Pengfei Gao,1 Yuan Yuan,1 Congcong Zhang,1 Yonglan Wang,1 Anjie Dong2 1Department of Periodontology, School and Hospital of Stomatology, Tianjin Medical University, Tianjin, People’s Republic of China; 2Department of Polymer Science and Technology and Key Laboratory of Systems Bioengineering of the Ministry of Education, School of Chemical Engineering and Technology, Tianjin University, Tianjin, People’s Republic of China Objective: The aims of this study were to 1) encapsulate ibuprofen (IBU) and basic fibroblast growth factor (bFGF) in a thermosensitive micellar hydrogel, 2) test the biological properties of this in situ drug delivery system, and 3) study the effect of hydrogel in promoting soft tissue healing after implant surgery and its anti-inflammatory function as an early local treatment of peri-implantitis.Materials and methods: A thermosensitive micellar hydrogel was prepared from amphiphilic copolymer poly(ε-caprolactone-co-1,4,8-trioxa [4.6]spiro-9-undecanone)-poly(ethylene glycol)-poly(ε-caprolactone-co-1,4,8-trioxa [4.6]spiro-9-undecanone) (PECT) nanoparticles and tested in vitro using a scanning electron microscope, rheometer, UV spectrophotometer, HPLC, and transmission electron microscope.Results: The bFGF + IBU/PECT hydrogel formed a stable, water-dispersible nanoparticle core shell that was injectable at room temperature, hydrogel in situ at body temperature, and provided sustained release of both hydrophilic and hydrophobic drugs. The hydrogel promoted the proliferation and adhesion of human gingival fibroblasts, upregulated the expression of adhesion factors such as vinculin proteins, and showed anti-inflammatory properties.Conclusion: In situ preparation of IBU- and bFGF-loaded PECT hydrogel represents a promising drug delivery system with the potential to provide early local treatment for peri-implantitis. Keywords: thermosensitive hydrogel, nanoparticles, dual drugs, peri-implantitis  Chen WZhi MFeng ZGao PYuan YZhang CWang YDong ADove Medical Pressarticlethermo-sensitivehydrogelnanoparticlesPECTdual drugsperi-implantitisMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 1347-1358 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	thermo-sensitive hydrogel nanoparticles PECT dual drugs peri-implantitis Medicine (General) R5-920
spellingShingle	thermo-sensitive hydrogel nanoparticles PECT dual drugs peri-implantitis Medicine (General) R5-920 Chen W Zhi M Feng Z Gao P Yuan Y Zhang C Wang Y Dong A Sustained co-delivery of ibuprofen and basic fibroblast growth factor by thermosensitive nanoparticle hydrogel as early local treatment of peri-implantitis
description	Wenlei Chen,1 Min Zhi,1 Zujian Feng,2 Pengfei Gao,1 Yuan Yuan,1 Congcong Zhang,1 Yonglan Wang,1 Anjie Dong2 1Department of Periodontology, School and Hospital of Stomatology, Tianjin Medical University, Tianjin, People’s Republic of China; 2Department of Polymer Science and Technology and Key Laboratory of Systems Bioengineering of the Ministry of Education, School of Chemical Engineering and Technology, Tianjin University, Tianjin, People’s Republic of China Objective: The aims of this study were to 1) encapsulate ibuprofen (IBU) and basic fibroblast growth factor (bFGF) in a thermosensitive micellar hydrogel, 2) test the biological properties of this in situ drug delivery system, and 3) study the effect of hydrogel in promoting soft tissue healing after implant surgery and its anti-inflammatory function as an early local treatment of peri-implantitis.Materials and methods: A thermosensitive micellar hydrogel was prepared from amphiphilic copolymer poly(ε-caprolactone-co-1,4,8-trioxa [4.6]spiro-9-undecanone)-poly(ethylene glycol)-poly(ε-caprolactone-co-1,4,8-trioxa [4.6]spiro-9-undecanone) (PECT) nanoparticles and tested in vitro using a scanning electron microscope, rheometer, UV spectrophotometer, HPLC, and transmission electron microscope.Results: The bFGF + IBU/PECT hydrogel formed a stable, water-dispersible nanoparticle core shell that was injectable at room temperature, hydrogel in situ at body temperature, and provided sustained release of both hydrophilic and hydrophobic drugs. The hydrogel promoted the proliferation and adhesion of human gingival fibroblasts, upregulated the expression of adhesion factors such as vinculin proteins, and showed anti-inflammatory properties.Conclusion: In situ preparation of IBU- and bFGF-loaded PECT hydrogel represents a promising drug delivery system with the potential to provide early local treatment for peri-implantitis. Keywords: thermosensitive hydrogel, nanoparticles, dual drugs, peri-implantitis
format	article
author	Chen W Zhi M Feng Z Gao P Yuan Y Zhang C Wang Y Dong A
author_facet	Chen W Zhi M Feng Z Gao P Yuan Y Zhang C Wang Y Dong A
author_sort	Chen W
title	Sustained co-delivery of ibuprofen and basic fibroblast growth factor by thermosensitive nanoparticle hydrogel as early local treatment of peri-implantitis
title_short	Sustained co-delivery of ibuprofen and basic fibroblast growth factor by thermosensitive nanoparticle hydrogel as early local treatment of peri-implantitis
title_full	Sustained co-delivery of ibuprofen and basic fibroblast growth factor by thermosensitive nanoparticle hydrogel as early local treatment of peri-implantitis
title_fullStr	Sustained co-delivery of ibuprofen and basic fibroblast growth factor by thermosensitive nanoparticle hydrogel as early local treatment of peri-implantitis
title_full_unstemmed	Sustained co-delivery of ibuprofen and basic fibroblast growth factor by thermosensitive nanoparticle hydrogel as early local treatment of peri-implantitis
title_sort	sustained co-delivery of ibuprofen and basic fibroblast growth factor by thermosensitive nanoparticle hydrogel as early local treatment of peri-implantitis
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/3290110da6b14877a21a6a225921358d
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Sustained co-delivery of ibuprofen and basic fibroblast growth factor by thermosensitive nanoparticle hydrogel as early local treatment of peri-implantitis

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