Genetic copy number variation and general cognitive ability.
Differences in genomic structure between individuals are ubiquitous features of human genetic variation. Specific copy number variants (CNVs) have been associated with susceptibility to numerous complex psychiatric disorders, including attention-deficit-hyperactivity disorder, autism-spectrum disord...
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2012
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oai:doaj.org-article:329512db8c22445eb0eedebcc80d79952021-11-18T08:03:50ZGenetic copy number variation and general cognitive ability.1932-620310.1371/journal.pone.0037385https://doaj.org/article/329512db8c22445eb0eedebcc80d79952012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23300510/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Differences in genomic structure between individuals are ubiquitous features of human genetic variation. Specific copy number variants (CNVs) have been associated with susceptibility to numerous complex psychiatric disorders, including attention-deficit-hyperactivity disorder, autism-spectrum disorders and schizophrenia. These disorders often display co-morbidity with low intelligence. Rare chromosomal deletions and duplications are associated with these disorders, so it has been suggested that these deletions or duplications may be associated with differences in intelligence. Here we investigate associations between large (≥500kb), rare (<1% population frequency) CNVs and both fluid and crystallized intelligence in community-dwelling older people. We observe no significant associations between intelligence and total CNV load. Examining individual CNV regions previously implicated in neuropsychological disorders, we find suggestive evidence that CNV regions around SHANK3 are associated with fluid intelligence as derived from a battery of cognitive tests. This is the first study to examine the effects of rare CNVs as called by multiple algorithms on cognition in a large non-clinical sample, and finds no effects of such variants on general cognitive ability.Andrew K MacLeodGail DaviesAntony PaytonAlbert TenesaSarah E HarrisDavid LiewaldXiayi KeMichelle LucianoLorna M LopezAlan J GowJanie CorleyPaul RedmondGeraldine McNeillAndrew PicklesWilliam OllierMichael HoranJohn M StarrNeil PendletonPippa A ThomsonDavid J PorteousIan J DearyPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 12, p e37385 (2012) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Andrew K MacLeod Gail Davies Antony Payton Albert Tenesa Sarah E Harris David Liewald Xiayi Ke Michelle Luciano Lorna M Lopez Alan J Gow Janie Corley Paul Redmond Geraldine McNeill Andrew Pickles William Ollier Michael Horan John M Starr Neil Pendleton Pippa A Thomson David J Porteous Ian J Deary Genetic copy number variation and general cognitive ability. |
| description |
Differences in genomic structure between individuals are ubiquitous features of human genetic variation. Specific copy number variants (CNVs) have been associated with susceptibility to numerous complex psychiatric disorders, including attention-deficit-hyperactivity disorder, autism-spectrum disorders and schizophrenia. These disorders often display co-morbidity with low intelligence. Rare chromosomal deletions and duplications are associated with these disorders, so it has been suggested that these deletions or duplications may be associated with differences in intelligence. Here we investigate associations between large (≥500kb), rare (<1% population frequency) CNVs and both fluid and crystallized intelligence in community-dwelling older people. We observe no significant associations between intelligence and total CNV load. Examining individual CNV regions previously implicated in neuropsychological disorders, we find suggestive evidence that CNV regions around SHANK3 are associated with fluid intelligence as derived from a battery of cognitive tests. This is the first study to examine the effects of rare CNVs as called by multiple algorithms on cognition in a large non-clinical sample, and finds no effects of such variants on general cognitive ability. |
| format |
article |
| author |
Andrew K MacLeod Gail Davies Antony Payton Albert Tenesa Sarah E Harris David Liewald Xiayi Ke Michelle Luciano Lorna M Lopez Alan J Gow Janie Corley Paul Redmond Geraldine McNeill Andrew Pickles William Ollier Michael Horan John M Starr Neil Pendleton Pippa A Thomson David J Porteous Ian J Deary |
| author_facet |
Andrew K MacLeod Gail Davies Antony Payton Albert Tenesa Sarah E Harris David Liewald Xiayi Ke Michelle Luciano Lorna M Lopez Alan J Gow Janie Corley Paul Redmond Geraldine McNeill Andrew Pickles William Ollier Michael Horan John M Starr Neil Pendleton Pippa A Thomson David J Porteous Ian J Deary |
| author_sort |
Andrew K MacLeod |
| title |
Genetic copy number variation and general cognitive ability. |
| title_short |
Genetic copy number variation and general cognitive ability. |
| title_full |
Genetic copy number variation and general cognitive ability. |
| title_fullStr |
Genetic copy number variation and general cognitive ability. |
| title_full_unstemmed |
Genetic copy number variation and general cognitive ability. |
| title_sort |
genetic copy number variation and general cognitive ability. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2012 |
| url |
https://doaj.org/article/329512db8c22445eb0eedebcc80d7995 |
| work_keys_str_mv |
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