Integrative pan cancer analysis reveals epigenomic variation in cancer type and cell specific chromatin domains

The NCI-60 cancer cell line panel covers multiple cancer types but has not been extensively investigated at the epigenetic level. Here, the authors present H3K4me3, H3K27ac, H3K9me3, and H4K20me3 ChIP-Seq analysis of the cell lines, and describe features of chromatin states and integrative analyses...

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Autores principales:	Lijin K. Gopi, Benjamin L. Kidder
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3295f73d665e4bdfa670695b17dfeea9
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spelling	oai:doaj.org-article:3295f73d665e4bdfa670695b17dfeea92021-12-02T15:53:25ZIntegrative pan cancer analysis reveals epigenomic variation in cancer type and cell specific chromatin domains10.1038/s41467-021-21707-12041-1723https://doaj.org/article/3295f73d665e4bdfa670695b17dfeea92021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21707-1https://doaj.org/toc/2041-1723The NCI-60 cancer cell line panel covers multiple cancer types but has not been extensively investigated at the epigenetic level. Here, the authors present H3K4me3, H3K27ac, H3K9me3, and H4K20me3 ChIP-Seq analysis of the cell lines, and describe features of chromatin states and integrative analyses of expression, epigenetic and genetic mutation data.Lijin K. GopiBenjamin L. KidderNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lijin K. Gopi Benjamin L. Kidder Integrative pan cancer analysis reveals epigenomic variation in cancer type and cell specific chromatin domains
description	The NCI-60 cancer cell line panel covers multiple cancer types but has not been extensively investigated at the epigenetic level. Here, the authors present H3K4me3, H3K27ac, H3K9me3, and H4K20me3 ChIP-Seq analysis of the cell lines, and describe features of chromatin states and integrative analyses of expression, epigenetic and genetic mutation data.
format	article
author	Lijin K. Gopi Benjamin L. Kidder
author_facet	Lijin K. Gopi Benjamin L. Kidder
author_sort	Lijin K. Gopi
title	Integrative pan cancer analysis reveals epigenomic variation in cancer type and cell specific chromatin domains
title_short	Integrative pan cancer analysis reveals epigenomic variation in cancer type and cell specific chromatin domains
title_full	Integrative pan cancer analysis reveals epigenomic variation in cancer type and cell specific chromatin domains
title_fullStr	Integrative pan cancer analysis reveals epigenomic variation in cancer type and cell specific chromatin domains
title_full_unstemmed	Integrative pan cancer analysis reveals epigenomic variation in cancer type and cell specific chromatin domains
title_sort	integrative pan cancer analysis reveals epigenomic variation in cancer type and cell specific chromatin domains
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3295f73d665e4bdfa670695b17dfeea9
work_keys_str_mv	AT lijinkgopi integrativepancanceranalysisrevealsepigenomicvariationincancertypeandcellspecificchromatindomains AT benjaminlkidder integrativepancanceranalysisrevealsepigenomicvariationincancertypeandcellspecificchromatindomains
_version_	1718385501790011392

Integrative pan cancer analysis reveals epigenomic variation in cancer type and cell specific chromatin domains

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