Molecular targeting of liposomal nanoparticles to tumor microenvironment

Gang Zhao,1,2 B Leticia Rodriguez21Institute of Materia Medica, Shandong Academy of Medical Science, Shandong, China; 2Pharmaceutics Division, College of Pharmacy, The University of Texas at Austin, Austin, TX, USAAbstract: Liposomes are biodegradable and can be used to deliver drugs at a much highe...

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Autores principales:	Zhao G, Rodriguez BL
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/32984ccb2a5d4dc7a3dbd65b6469ca3d
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spelling	oai:doaj.org-article:32984ccb2a5d4dc7a3dbd65b6469ca3d2021-12-02T05:40:38ZMolecular targeting of liposomal nanoparticles to tumor microenvironment1176-91141178-2013https://doaj.org/article/32984ccb2a5d4dc7a3dbd65b6469ca3d2012-12-01T00:00:00Zhttp://www.dovepress.com/molecular-targeting-of-liposomal-nanoparticles-to-tumor-microenvironme-a11833https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Gang Zhao,1,2 B Leticia Rodriguez21Institute of Materia Medica, Shandong Academy of Medical Science, Shandong, China; 2Pharmaceutics Division, College of Pharmacy, The University of Texas at Austin, Austin, TX, USAAbstract: Liposomes are biodegradable and can be used to deliver drugs at a much higher concentration in tumor tissues than in normal tissues. Both passive and active drug delivery by liposomal nanoparticles can significantly reduce the toxic side effects of anticancer drugs and enhance the therapeutic efficacy of the drugs delivered. Active liposomal targeting to tumors is achieved by recognizing specific tumor receptors through tumor-specific ligands or antibodies coupled onto the surface of the liposomes, or by stimulus-sensitive drug carriers such as acid-triggered release or enzyme-triggered drug release. Tumors are often composed of tumor cells and nontumor cells, which include endothelial cells, pericytes, fibroblasts, stromal, mesenchymal cells, innate, and adaptive immune cells. These nontumor cells thus form the tumor microenvironment, which could be targeted and modified so that it is unfavorable for tumor cells to grow. In this review, we briefly summarized articles that had taken advantage of liposomal nanoparticles as a carrier to deliver anticancer drugs to the tumor microenvironment, and how they overcame obstacles such as nonspecific uptake, interaction with components in blood, and toxicity. Special attention is devoted to the liposomal targeting of anticancer drugs to the endothelium of tumor neovasculature, tumor associated macrophages, fibroblasts, and pericytes within the tumor microenvironment.Keywords: tumor microenvironment, endothelium, neovasculature, tumor-associated macrophages, cationic liposomes, ligand- or antibody-mediated targetingZhao GRodriguez BLDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2013, Iss default, Pp 61-71 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Zhao G Rodriguez BL Molecular targeting of liposomal nanoparticles to tumor microenvironment
description	Gang Zhao,1,2 B Leticia Rodriguez21Institute of Materia Medica, Shandong Academy of Medical Science, Shandong, China; 2Pharmaceutics Division, College of Pharmacy, The University of Texas at Austin, Austin, TX, USAAbstract: Liposomes are biodegradable and can be used to deliver drugs at a much higher concentration in tumor tissues than in normal tissues. Both passive and active drug delivery by liposomal nanoparticles can significantly reduce the toxic side effects of anticancer drugs and enhance the therapeutic efficacy of the drugs delivered. Active liposomal targeting to tumors is achieved by recognizing specific tumor receptors through tumor-specific ligands or antibodies coupled onto the surface of the liposomes, or by stimulus-sensitive drug carriers such as acid-triggered release or enzyme-triggered drug release. Tumors are often composed of tumor cells and nontumor cells, which include endothelial cells, pericytes, fibroblasts, stromal, mesenchymal cells, innate, and adaptive immune cells. These nontumor cells thus form the tumor microenvironment, which could be targeted and modified so that it is unfavorable for tumor cells to grow. In this review, we briefly summarized articles that had taken advantage of liposomal nanoparticles as a carrier to deliver anticancer drugs to the tumor microenvironment, and how they overcame obstacles such as nonspecific uptake, interaction with components in blood, and toxicity. Special attention is devoted to the liposomal targeting of anticancer drugs to the endothelium of tumor neovasculature, tumor associated macrophages, fibroblasts, and pericytes within the tumor microenvironment.Keywords: tumor microenvironment, endothelium, neovasculature, tumor-associated macrophages, cationic liposomes, ligand- or antibody-mediated targeting
format	article
author	Zhao G Rodriguez BL
author_facet	Zhao G Rodriguez BL
author_sort	Zhao G
title	Molecular targeting of liposomal nanoparticles to tumor microenvironment
title_short	Molecular targeting of liposomal nanoparticles to tumor microenvironment
title_full	Molecular targeting of liposomal nanoparticles to tumor microenvironment
title_fullStr	Molecular targeting of liposomal nanoparticles to tumor microenvironment
title_full_unstemmed	Molecular targeting of liposomal nanoparticles to tumor microenvironment
title_sort	molecular targeting of liposomal nanoparticles to tumor microenvironment
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/32984ccb2a5d4dc7a3dbd65b6469ca3d
work_keys_str_mv	AT zhaog moleculartargetingofliposomalnanoparticlestotumormicroenvironment AT rodriguezbl moleculartargetingofliposomalnanoparticlestotumormicroenvironment
_version_	1718400287392137216

Molecular targeting of liposomal nanoparticles to tumor microenvironment

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