Tumor targeting using liposomal antineoplastic drugs
Jörg Huwyler1, Jürgen Drewe2, Stephan Krähenbühl21University of Applied Sciences Northwestern Switzerland, Institute of Pharma Technology, Muttenz, Switzerland; 2Department of Research and Division of Clinical Pharmacology, University Hospital Base...
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Dove Medical Press
2008
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oai:doaj.org-article:329bc4eda00f43dfb5b77bec7ef53dcd2021-12-02T06:46:22ZTumor targeting using liposomal antineoplastic drugs1176-91141178-2013https://doaj.org/article/329bc4eda00f43dfb5b77bec7ef53dcd2008-03-01T00:00:00Zhttp://www.dovepress.com/tumor-targeting-using-liposomal-antineoplastic-drugs-a735https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Jörg Huwyler1, Jürgen Drewe2, Stephan Krähenbühl21University of Applied Sciences Northwestern Switzerland, Institute of Pharma Technology, Muttenz, Switzerland; 2Department of Research and Division of Clinical Pharmacology, University Hospital Basel, Basel, SwitzerlandAbstract: During the last years, liposomes (microparticulate phospholipid vesicles) have beenused with growing success as pharmaceutical carriers for antineoplastic drugs. Fields of application include lipid-based formulations to enhance the solubility of poorly soluble antitumordrugs, the use of pegylated liposomes for passive targeting of solid tumors as well as vector-conjugated liposomal carriers for active targeting of tumor tissue. Such formulation and drug targeting strategies enhance the effectiveness of anticancer chemotherapy and reduce at the same time the risk of toxic side-effects. The present article reviews the principles of different liposomal technologies and discusses current trends in this field of research.Keywords: tumor targeting, antineoplastic drugs, liposomes, pegylation, steric stabilization, immunoliposomes Jörg HuwylerJürgen DreweStephan KrähenbühlDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2008, Iss Issue 1, Pp 21-29 (2008) |
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DOAJ |
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DOAJ |
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EN |
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Medicine (General) R5-920 |
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Medicine (General) R5-920 Jörg Huwyler Jürgen Drewe Stephan Krähenbühl Tumor targeting using liposomal antineoplastic drugs |
| description |
Jörg Huwyler1, Jürgen Drewe2, Stephan Krähenbühl21University of Applied Sciences Northwestern Switzerland, Institute of Pharma Technology, Muttenz, Switzerland; 2Department of Research and Division of Clinical Pharmacology, University Hospital Basel, Basel, SwitzerlandAbstract: During the last years, liposomes (microparticulate phospholipid vesicles) have beenused with growing success as pharmaceutical carriers for antineoplastic drugs. Fields of application include lipid-based formulations to enhance the solubility of poorly soluble antitumordrugs, the use of pegylated liposomes for passive targeting of solid tumors as well as vector-conjugated liposomal carriers for active targeting of tumor tissue. Such formulation and drug targeting strategies enhance the effectiveness of anticancer chemotherapy and reduce at the same time the risk of toxic side-effects. The present article reviews the principles of different liposomal technologies and discusses current trends in this field of research.Keywords: tumor targeting, antineoplastic drugs, liposomes, pegylation, steric stabilization, immunoliposomes |
| format |
article |
| author |
Jörg Huwyler Jürgen Drewe Stephan Krähenbühl |
| author_facet |
Jörg Huwyler Jürgen Drewe Stephan Krähenbühl |
| author_sort |
Jörg Huwyler |
| title |
Tumor targeting using liposomal antineoplastic drugs |
| title_short |
Tumor targeting using liposomal antineoplastic drugs |
| title_full |
Tumor targeting using liposomal antineoplastic drugs |
| title_fullStr |
Tumor targeting using liposomal antineoplastic drugs |
| title_full_unstemmed |
Tumor targeting using liposomal antineoplastic drugs |
| title_sort |
tumor targeting using liposomal antineoplastic drugs |
| publisher |
Dove Medical Press |
| publishDate |
2008 |
| url |
https://doaj.org/article/329bc4eda00f43dfb5b77bec7ef53dcd |
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| _version_ |
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