Soluble CD40 in plasma and malignant pleural effusion with non-small cell lung cancer: A potential marker of prognosis

Objective: Soluble CD40 (sCD40) is a potential modulator for both antitumor responses and CD40-based immunotherapy; however the levels and significance of sCD40 in non-small cell lung cancer (NSCLC) patients with malignant pleural effusion are unknown. Methods: Forty-eight patients with lung cancer...

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Autores principales:	Chuan-Yong Mu, Pang-Xue Qin, Qiu-Xia Qu, Cheng Chen, Jian-An Huang
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2015
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/329cb7b479a049c5a57f6d5c4e23ac55
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spelling	oai:doaj.org-article:329cb7b479a049c5a57f6d5c4e23ac552021-12-02T14:35:05ZSoluble CD40 in plasma and malignant pleural effusion with non-small cell lung cancer: A potential marker of prognosis2095-882X10.1016/j.cdtm.2015.02.010https://doaj.org/article/329cb7b479a049c5a57f6d5c4e23ac552015-03-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2095882X15000110https://doaj.org/toc/2095-882XObjective: Soluble CD40 (sCD40) is a potential modulator for both antitumor responses and CD40-based immunotherapy; however the levels and significance of sCD40 in non-small cell lung cancer (NSCLC) patients with malignant pleural effusion are unknown. Methods: Forty-eight patients with lung cancer were treated in our institutions from January 2008 to January 2010. Peripheral blood and pleural effusion samples were collected from each subject. sCD40 levels in plasma and malignant pleural effusions supernatant were measured. The CD40L expression on CD3t T-cells was confirmed by flow cytometric direct immunofluorescence analysis. All patients were followed up after the study ended on January 1, 2010. Results: Patients with malignant pleural effusion of NSCLC had elevated circulating and pleural effusion levels of sCD40, and these elevated sCD40 levels were associated with advanced diseases and a poor prognosis. Conclusions: These findings indicate that elevated sCD40 may have a role in modulating antitumor responses and may also be a useful prognostic marker. Keywords: Soluble CD40, Malignant pleural effusion, PrognosisChuan-Yong MuPang-Xue QinQiu-Xia QuCheng ChenJian-An HuangKeAi Communications Co., Ltd.articleMedicine (General)R5-920ENChronic Diseases and Translational Medicine, Vol 1, Iss 1, Pp 36-41 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Chuan-Yong Mu Pang-Xue Qin Qiu-Xia Qu Cheng Chen Jian-An Huang Soluble CD40 in plasma and malignant pleural effusion with non-small cell lung cancer: A potential marker of prognosis
description	Objective: Soluble CD40 (sCD40) is a potential modulator for both antitumor responses and CD40-based immunotherapy; however the levels and significance of sCD40 in non-small cell lung cancer (NSCLC) patients with malignant pleural effusion are unknown. Methods: Forty-eight patients with lung cancer were treated in our institutions from January 2008 to January 2010. Peripheral blood and pleural effusion samples were collected from each subject. sCD40 levels in plasma and malignant pleural effusions supernatant were measured. The CD40L expression on CD3t T-cells was confirmed by flow cytometric direct immunofluorescence analysis. All patients were followed up after the study ended on January 1, 2010. Results: Patients with malignant pleural effusion of NSCLC had elevated circulating and pleural effusion levels of sCD40, and these elevated sCD40 levels were associated with advanced diseases and a poor prognosis. Conclusions: These findings indicate that elevated sCD40 may have a role in modulating antitumor responses and may also be a useful prognostic marker. Keywords: Soluble CD40, Malignant pleural effusion, Prognosis
format	article
author	Chuan-Yong Mu Pang-Xue Qin Qiu-Xia Qu Cheng Chen Jian-An Huang
author_facet	Chuan-Yong Mu Pang-Xue Qin Qiu-Xia Qu Cheng Chen Jian-An Huang
author_sort	Chuan-Yong Mu
title	Soluble CD40 in plasma and malignant pleural effusion with non-small cell lung cancer: A potential marker of prognosis
title_short	Soluble CD40 in plasma and malignant pleural effusion with non-small cell lung cancer: A potential marker of prognosis
title_full	Soluble CD40 in plasma and malignant pleural effusion with non-small cell lung cancer: A potential marker of prognosis
title_fullStr	Soluble CD40 in plasma and malignant pleural effusion with non-small cell lung cancer: A potential marker of prognosis
title_full_unstemmed	Soluble CD40 in plasma and malignant pleural effusion with non-small cell lung cancer: A potential marker of prognosis
title_sort	soluble cd40 in plasma and malignant pleural effusion with non-small cell lung cancer: a potential marker of prognosis
publisher	KeAi Communications Co., Ltd.
publishDate	2015
url	https://doaj.org/article/329cb7b479a049c5a57f6d5c4e23ac55
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Soluble CD40 in plasma and malignant pleural effusion with non-small cell lung cancer: A potential marker of prognosis

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