Albuminuria Pre-Emptively Identifies Cardiac Patients at Risk of Contrast-Induced Nephropathy

Contrast-induced nephropathy (CIN) is a complication associated with the administration of contrast media (CM). The CIN diagnosis is based on creatinine, a biomarker late and insensitive. The objective proposed was to evaluate the ability of novel biomarkers to detect patients susceptible to sufferi...

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Autores principales:	Laura Vicente-Vicente, Alfredo G. Casanova, M. Teresa Hernández-Sánchez, Marta Prieto, Carlos Martínez-Salgado, Francisco J. López-Hernández, Ignacio Cruz-González, Ana I. Morales
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	contrast-induced nephropathy albuminuria diagnosis contrast media Medicine R
Acceso en línea:	https://doaj.org/article/32a8926af4fd40109f8148a40245162f
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spelling	oai:doaj.org-article:32a8926af4fd40109f8148a40245162f2021-11-11T17:34:50ZAlbuminuria Pre-Emptively Identifies Cardiac Patients at Risk of Contrast-Induced Nephropathy10.3390/jcm102149422077-0383https://doaj.org/article/32a8926af4fd40109f8148a40245162f2021-10-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/4942https://doaj.org/toc/2077-0383Contrast-induced nephropathy (CIN) is a complication associated with the administration of contrast media (CM). The CIN diagnosis is based on creatinine, a biomarker late and insensitive. The objective proposed was to evaluate the ability of novel biomarkers to detect patients susceptible to suffering CIN before CM administration. The study was carried out with patients undergoing cardiac catheterization involving CM. Patients were divided into two groups: (1) CIN, patients who developed this pathology; (2) control, patients who did not suffer CIN. Prior to the administration of CM, urine samples were collected to measure proteinuria, <i>N</i>-acetyl-β-<span style="font-variant: small-caps;">d</span>-glucosaminidase, neutrophil gelatinase-associated lipocalin and kidney injury molecule-1, albumin, transferrin, t-gelsolin and GM2 ganglioside activator protein (GM2AP). The risk factors advanced age, low body mass index and low estimated glomerular filtration rate; and the urinary biomarkers albumin, transferrin and GM2AP showed significant predictive capacity. Of all of them, albuminuria demonstrated the highest diagnostic power. When a cutoff point was established for albuminuria at values still considered subclinical (10–30 µg/mg Cr<sub>u</sub>), it was found that there was a high incidence of CIN (40–75%). Therefore, albuminuria could be applied as a new diagnostic tool to prevent and predict CIN with P4 medicine criteria, independently of risk factors and comorbidities.Laura Vicente-VicenteAlfredo G. CasanovaM. Teresa Hernández-SánchezMarta PrietoCarlos Martínez-SalgadoFrancisco J. López-HernándezIgnacio Cruz-GonzálezAna I. MoralesMDPI AGarticlecontrast-induced nephropathyalbuminuriadiagnosiscontrast mediaMedicineRENJournal of Clinical Medicine, Vol 10, Iss 4942, p 4942 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	contrast-induced nephropathy albuminuria diagnosis contrast media Medicine R
spellingShingle	contrast-induced nephropathy albuminuria diagnosis contrast media Medicine R Laura Vicente-Vicente Alfredo G. Casanova M. Teresa Hernández-Sánchez Marta Prieto Carlos Martínez-Salgado Francisco J. López-Hernández Ignacio Cruz-González Ana I. Morales Albuminuria Pre-Emptively Identifies Cardiac Patients at Risk of Contrast-Induced Nephropathy
description	Contrast-induced nephropathy (CIN) is a complication associated with the administration of contrast media (CM). The CIN diagnosis is based on creatinine, a biomarker late and insensitive. The objective proposed was to evaluate the ability of novel biomarkers to detect patients susceptible to suffering CIN before CM administration. The study was carried out with patients undergoing cardiac catheterization involving CM. Patients were divided into two groups: (1) CIN, patients who developed this pathology; (2) control, patients who did not suffer CIN. Prior to the administration of CM, urine samples were collected to measure proteinuria, <i>N</i>-acetyl-β-<span style="font-variant: small-caps;">d</span>-glucosaminidase, neutrophil gelatinase-associated lipocalin and kidney injury molecule-1, albumin, transferrin, t-gelsolin and GM2 ganglioside activator protein (GM2AP). The risk factors advanced age, low body mass index and low estimated glomerular filtration rate; and the urinary biomarkers albumin, transferrin and GM2AP showed significant predictive capacity. Of all of them, albuminuria demonstrated the highest diagnostic power. When a cutoff point was established for albuminuria at values still considered subclinical (10–30 µg/mg Cr<sub>u</sub>), it was found that there was a high incidence of CIN (40–75%). Therefore, albuminuria could be applied as a new diagnostic tool to prevent and predict CIN with P4 medicine criteria, independently of risk factors and comorbidities.
format	article
author	Laura Vicente-Vicente Alfredo G. Casanova M. Teresa Hernández-Sánchez Marta Prieto Carlos Martínez-Salgado Francisco J. López-Hernández Ignacio Cruz-González Ana I. Morales
author_facet	Laura Vicente-Vicente Alfredo G. Casanova M. Teresa Hernández-Sánchez Marta Prieto Carlos Martínez-Salgado Francisco J. López-Hernández Ignacio Cruz-González Ana I. Morales
author_sort	Laura Vicente-Vicente
title	Albuminuria Pre-Emptively Identifies Cardiac Patients at Risk of Contrast-Induced Nephropathy
title_short	Albuminuria Pre-Emptively Identifies Cardiac Patients at Risk of Contrast-Induced Nephropathy
title_full	Albuminuria Pre-Emptively Identifies Cardiac Patients at Risk of Contrast-Induced Nephropathy
title_fullStr	Albuminuria Pre-Emptively Identifies Cardiac Patients at Risk of Contrast-Induced Nephropathy
title_full_unstemmed	Albuminuria Pre-Emptively Identifies Cardiac Patients at Risk of Contrast-Induced Nephropathy
title_sort	albuminuria pre-emptively identifies cardiac patients at risk of contrast-induced nephropathy
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/32a8926af4fd40109f8148a40245162f
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Albuminuria Pre-Emptively Identifies Cardiac Patients at Risk of Contrast-Induced Nephropathy

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