CT for estimating adequacy of lymph node dissection in patients with squamous cell carcinoma of the head and neck

Abstract Background Indices obtained from lymph node dissection specimens, specifically lymph node yield (LNY) and lymph node ratio (LNR), have prognostic significance in the setting of head and neck squamous cell carcinoma (HNSCCa). However, there are currently no validated tools to estimate adequa...

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Autores principales:	Christiaan A. Rees, Joshua H. Litchman, Xiaotian Wu, Mariah M. Servos, Darcy A. Kerr, Ryan J. Halter, David A. Pastel, Joseph A. Paydarfar
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	3D reconstruction Computational modeling Head and neck Lymph node ratio Lymph node yield Neck dissection Medical physics. Medical radiology. Nuclear medicine R895-920 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/32aaf4994b864b8aa4d3dbff9244ca60
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spelling	oai:doaj.org-article:32aaf4994b864b8aa4d3dbff9244ca602021-11-28T12:41:30ZCT for estimating adequacy of lymph node dissection in patients with squamous cell carcinoma of the head and neck10.1186/s40644-021-00430-61470-7330https://doaj.org/article/32aaf4994b864b8aa4d3dbff9244ca602021-11-01T00:00:00Zhttps://doi.org/10.1186/s40644-021-00430-6https://doaj.org/toc/1470-7330Abstract Background Indices obtained from lymph node dissection specimens, specifically lymph node yield (LNY) and lymph node ratio (LNR), have prognostic significance in the setting of head and neck squamous cell carcinoma (HNSCCa). However, there are currently no validated tools to estimate adequacy of planned lymph node dissection using preoperative data. The present study sought to evaluate CT-derived estimates of lymphatic tissue volumes as a preoperative tool to guide cervical node dissection. Methods Fifteen cervical lymph node dissections were performed in 14 subjects with HNSCCa. Preoperative CT-derived estimates of lymphatic tissue volumes were compared with gross pathology tissue volume estimates and pathologically-determined LNY. Results Resected tissue volume (calculated using the triaxial ellipsoid method) correlates with CT-derived preoperative lymphatic volume estimates (r = 0.74, p = 0.003) while LNY does not(r = − 0.12, p = 0.67). When excluding pathologically enlarged lymph nodes (“refined” data), a negative correlation was observed between refined CT-derived volume estimates and refined LNY (r = − 0.65, p = 0.009). Conclusion In the setting of cervical lymph node dissection, CT-derived lymphatic volume estimates correlate with resected tissue volume, but refined CT-derived volume estimates correlate negatively with refined LNY. Trial registration Retrospectively registered. Level of evidence 4Christiaan A. ReesJoshua H. LitchmanXiaotian WuMariah M. ServosDarcy A. KerrRyan J. HalterDavid A. PastelJoseph A. PaydarfarBMCarticle3D reconstructionComputational modelingHead and neckLymph node ratioLymph node yieldNeck dissectionMedical physics. Medical radiology. Nuclear medicineR895-920Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancer Imaging, Vol 21, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	3D reconstruction Computational modeling Head and neck Lymph node ratio Lymph node yield Neck dissection Medical physics. Medical radiology. Nuclear medicine R895-920 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	3D reconstruction Computational modeling Head and neck Lymph node ratio Lymph node yield Neck dissection Medical physics. Medical radiology. Nuclear medicine R895-920 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Christiaan A. Rees Joshua H. Litchman Xiaotian Wu Mariah M. Servos Darcy A. Kerr Ryan J. Halter David A. Pastel Joseph A. Paydarfar CT for estimating adequacy of lymph node dissection in patients with squamous cell carcinoma of the head and neck
description	Abstract Background Indices obtained from lymph node dissection specimens, specifically lymph node yield (LNY) and lymph node ratio (LNR), have prognostic significance in the setting of head and neck squamous cell carcinoma (HNSCCa). However, there are currently no validated tools to estimate adequacy of planned lymph node dissection using preoperative data. The present study sought to evaluate CT-derived estimates of lymphatic tissue volumes as a preoperative tool to guide cervical node dissection. Methods Fifteen cervical lymph node dissections were performed in 14 subjects with HNSCCa. Preoperative CT-derived estimates of lymphatic tissue volumes were compared with gross pathology tissue volume estimates and pathologically-determined LNY. Results Resected tissue volume (calculated using the triaxial ellipsoid method) correlates with CT-derived preoperative lymphatic volume estimates (r = 0.74, p = 0.003) while LNY does not(r = − 0.12, p = 0.67). When excluding pathologically enlarged lymph nodes (“refined” data), a negative correlation was observed between refined CT-derived volume estimates and refined LNY (r = − 0.65, p = 0.009). Conclusion In the setting of cervical lymph node dissection, CT-derived lymphatic volume estimates correlate with resected tissue volume, but refined CT-derived volume estimates correlate negatively with refined LNY. Trial registration Retrospectively registered. Level of evidence 4
format	article
author	Christiaan A. Rees Joshua H. Litchman Xiaotian Wu Mariah M. Servos Darcy A. Kerr Ryan J. Halter David A. Pastel Joseph A. Paydarfar
author_facet	Christiaan A. Rees Joshua H. Litchman Xiaotian Wu Mariah M. Servos Darcy A. Kerr Ryan J. Halter David A. Pastel Joseph A. Paydarfar
author_sort	Christiaan A. Rees
title	CT for estimating adequacy of lymph node dissection in patients with squamous cell carcinoma of the head and neck
title_short	CT for estimating adequacy of lymph node dissection in patients with squamous cell carcinoma of the head and neck
title_full	CT for estimating adequacy of lymph node dissection in patients with squamous cell carcinoma of the head and neck
title_fullStr	CT for estimating adequacy of lymph node dissection in patients with squamous cell carcinoma of the head and neck
title_full_unstemmed	CT for estimating adequacy of lymph node dissection in patients with squamous cell carcinoma of the head and neck
title_sort	ct for estimating adequacy of lymph node dissection in patients with squamous cell carcinoma of the head and neck
publisher	BMC
publishDate	2021
url	https://doaj.org/article/32aaf4994b864b8aa4d3dbff9244ca60
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CT for estimating adequacy of lymph node dissection in patients with squamous cell carcinoma of the head and neck

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