Unwinding of a DNA replication fork by a hexameric viral helicase

Replicative hexameric helicases are fundamental components of replisomes. Here the authors resolve a cryo-EM structure of the E1 helicase from papillomavirus bound to a DNA replication fork, providing insights into the mechanism of DNA unwinding by these hexameric enzymes.

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Autores principales:	Abid Javed, Balazs Major, Jonathan A. Stead, Cyril M. Sanders, Elena V. Orlova
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/32ab17c170964352825d558a35b79273
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spelling	oai:doaj.org-article:32ab17c170964352825d558a35b792732021-12-02T17:26:50ZUnwinding of a DNA replication fork by a hexameric viral helicase10.1038/s41467-021-25843-62041-1723https://doaj.org/article/32ab17c170964352825d558a35b792732021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25843-6https://doaj.org/toc/2041-1723Replicative hexameric helicases are fundamental components of replisomes. Here the authors resolve a cryo-EM structure of the E1 helicase from papillomavirus bound to a DNA replication fork, providing insights into the mechanism of DNA unwinding by these hexameric enzymes.Abid JavedBalazs MajorJonathan A. SteadCyril M. SandersElena V. OrlovaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Abid Javed Balazs Major Jonathan A. Stead Cyril M. Sanders Elena V. Orlova Unwinding of a DNA replication fork by a hexameric viral helicase
description	Replicative hexameric helicases are fundamental components of replisomes. Here the authors resolve a cryo-EM structure of the E1 helicase from papillomavirus bound to a DNA replication fork, providing insights into the mechanism of DNA unwinding by these hexameric enzymes.
format	article
author	Abid Javed Balazs Major Jonathan A. Stead Cyril M. Sanders Elena V. Orlova
author_facet	Abid Javed Balazs Major Jonathan A. Stead Cyril M. Sanders Elena V. Orlova
author_sort	Abid Javed
title	Unwinding of a DNA replication fork by a hexameric viral helicase
title_short	Unwinding of a DNA replication fork by a hexameric viral helicase
title_full	Unwinding of a DNA replication fork by a hexameric viral helicase
title_fullStr	Unwinding of a DNA replication fork by a hexameric viral helicase
title_full_unstemmed	Unwinding of a DNA replication fork by a hexameric viral helicase
title_sort	unwinding of a dna replication fork by a hexameric viral helicase
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/32ab17c170964352825d558a35b79273
work_keys_str_mv	AT abidjaved unwindingofadnareplicationforkbyahexamericviralhelicase AT balazsmajor unwindingofadnareplicationforkbyahexamericviralhelicase AT jonathanastead unwindingofadnareplicationforkbyahexamericviralhelicase AT cyrilmsanders unwindingofadnareplicationforkbyahexamericviralhelicase AT elenavorlova unwindingofadnareplicationforkbyahexamericviralhelicase
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Unwinding of a DNA replication fork by a hexameric viral helicase

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