The TLR7/8 agonist R848 remodels tumor and host responses to promote survival in pancreatic cancer

In the treatment of pancreatic ductal adenocarcinoma (PDAC), comorbidities such as cachexia limit quality of life and survival. Here, the authors show TLR7/8 agonist R848 remodels host and tumour immune responses, promoting survival and attenuating cachexia in murine models of PDAC.

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Autores principales:	Katherine A. Michaelis, Mason A. Norgard, Xinxia Zhu, Peter R. Levasseur, Shamilene Sivagnanam, Shannon M. Liudahl, Kevin G. Burfeind, Brennan Olson, Katherine R. Pelz, Diana M. Angeles Ramos, H. Carlo Maurer, Kenneth P. Olive, Lisa M. Coussens, Terry K. Morgan, Daniel L. Marks
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/32ad424ed67248b39855a6f6ea030e5f
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spelling	oai:doaj.org-article:32ad424ed67248b39855a6f6ea030e5f2021-12-02T17:32:40ZThe TLR7/8 agonist R848 remodels tumor and host responses to promote survival in pancreatic cancer10.1038/s41467-019-12657-w2041-1723https://doaj.org/article/32ad424ed67248b39855a6f6ea030e5f2019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12657-whttps://doaj.org/toc/2041-1723In the treatment of pancreatic ductal adenocarcinoma (PDAC), comorbidities such as cachexia limit quality of life and survival. Here, the authors show TLR7/8 agonist R848 remodels host and tumour immune responses, promoting survival and attenuating cachexia in murine models of PDAC.Katherine A. MichaelisMason A. NorgardXinxia ZhuPeter R. LevasseurShamilene SivagnanamShannon M. LiudahlKevin G. BurfeindBrennan OlsonKatherine R. PelzDiana M. Angeles RamosH. Carlo MaurerKenneth P. OliveLisa M. CoussensTerry K. MorganDaniel L. MarksNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Katherine A. Michaelis Mason A. Norgard Xinxia Zhu Peter R. Levasseur Shamilene Sivagnanam Shannon M. Liudahl Kevin G. Burfeind Brennan Olson Katherine R. Pelz Diana M. Angeles Ramos H. Carlo Maurer Kenneth P. Olive Lisa M. Coussens Terry K. Morgan Daniel L. Marks The TLR7/8 agonist R848 remodels tumor and host responses to promote survival in pancreatic cancer
description	In the treatment of pancreatic ductal adenocarcinoma (PDAC), comorbidities such as cachexia limit quality of life and survival. Here, the authors show TLR7/8 agonist R848 remodels host and tumour immune responses, promoting survival and attenuating cachexia in murine models of PDAC.
format	article
author	Katherine A. Michaelis Mason A. Norgard Xinxia Zhu Peter R. Levasseur Shamilene Sivagnanam Shannon M. Liudahl Kevin G. Burfeind Brennan Olson Katherine R. Pelz Diana M. Angeles Ramos H. Carlo Maurer Kenneth P. Olive Lisa M. Coussens Terry K. Morgan Daniel L. Marks
author_facet	Katherine A. Michaelis Mason A. Norgard Xinxia Zhu Peter R. Levasseur Shamilene Sivagnanam Shannon M. Liudahl Kevin G. Burfeind Brennan Olson Katherine R. Pelz Diana M. Angeles Ramos H. Carlo Maurer Kenneth P. Olive Lisa M. Coussens Terry K. Morgan Daniel L. Marks
author_sort	Katherine A. Michaelis
title	The TLR7/8 agonist R848 remodels tumor and host responses to promote survival in pancreatic cancer
title_short	The TLR7/8 agonist R848 remodels tumor and host responses to promote survival in pancreatic cancer
title_full	The TLR7/8 agonist R848 remodels tumor and host responses to promote survival in pancreatic cancer
title_fullStr	The TLR7/8 agonist R848 remodels tumor and host responses to promote survival in pancreatic cancer
title_full_unstemmed	The TLR7/8 agonist R848 remodels tumor and host responses to promote survival in pancreatic cancer
title_sort	tlr7/8 agonist r848 remodels tumor and host responses to promote survival in pancreatic cancer
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/32ad424ed67248b39855a6f6ea030e5f
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The TLR7/8 agonist R848 remodels tumor and host responses to promote survival in pancreatic cancer

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