Whole-Genome Transformation Promotes tRNA Anticodon Suppressor Mutations under Stress

In this work, we have identified for the first time the causative elements in a eukaryotic organism introduced by applying whole-genome transformation and responsible for the selectable trait of interest, i.e., high temperature tolerance. Surprisingly, the whole-genome transformants contained just...

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Autores principales:	Quinten Deparis, Jorge Duitama, Maria R. Foulquié-Moreno, Johan M. Thevelein
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2021
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/32af746842d947128722c835f94c1734
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spelling	oai:doaj.org-article:32af746842d947128722c835f94c17342021-11-03T18:56:10ZWhole-Genome Transformation Promotes tRNA Anticodon Suppressor Mutations under Stress2150-751110.1128/mBio.03649-20https://doaj.org/article/32af746842d947128722c835f94c17342021-04-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.03649-20https://doaj.org/toc/2150-7511 In this work, we have identified for the first time the causative elements in a eukaryotic organism introduced by applying whole-genome transformation and responsible for the selectable trait of interest, i.e., high temperature tolerance. Surprisingly, the whole-genome transformants contained just a few single nucleotide polymorphisms (SNPs), which were unrelated to the sequence of the donor DNA.Quinten DeparisJorge DuitamaMaria R. Foulquié-MorenoJohan M. TheveleinAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 12, Iss 2 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Quinten Deparis Jorge Duitama Maria R. Foulquié-Moreno Johan M. Thevelein Whole-Genome Transformation Promotes tRNA Anticodon Suppressor Mutations under Stress
description	In this work, we have identified for the first time the causative elements in a eukaryotic organism introduced by applying whole-genome transformation and responsible for the selectable trait of interest, i.e., high temperature tolerance. Surprisingly, the whole-genome transformants contained just a few single nucleotide polymorphisms (SNPs), which were unrelated to the sequence of the donor DNA.
format	article
author	Quinten Deparis Jorge Duitama Maria R. Foulquié-Moreno Johan M. Thevelein
author_facet	Quinten Deparis Jorge Duitama Maria R. Foulquié-Moreno Johan M. Thevelein
author_sort	Quinten Deparis
title	Whole-Genome Transformation Promotes tRNA Anticodon Suppressor Mutations under Stress
title_short	Whole-Genome Transformation Promotes tRNA Anticodon Suppressor Mutations under Stress
title_full	Whole-Genome Transformation Promotes tRNA Anticodon Suppressor Mutations under Stress
title_fullStr	Whole-Genome Transformation Promotes tRNA Anticodon Suppressor Mutations under Stress
title_full_unstemmed	Whole-Genome Transformation Promotes tRNA Anticodon Suppressor Mutations under Stress
title_sort	whole-genome transformation promotes trna anticodon suppressor mutations under stress
publisher	American Society for Microbiology
publishDate	2021
url	https://doaj.org/article/32af746842d947128722c835f94c1734
work_keys_str_mv	AT quintendeparis wholegenometransformationpromotestrnaanticodonsuppressormutationsunderstress AT jorgeduitama wholegenometransformationpromotestrnaanticodonsuppressormutationsunderstress AT mariarfoulquiemoreno wholegenometransformationpromotestrnaanticodonsuppressormutationsunderstress AT johanmthevelein wholegenometransformationpromotestrnaanticodonsuppressormutationsunderstress
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Whole-Genome Transformation Promotes tRNA Anticodon Suppressor Mutations under Stress

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