Essential role of FBXL5-mediated cellular iron homeostasis in maintenance of hematopoietic stem cells

The iron-regulated F-box protein FBXL5 regulates iron homeostasis by mediating the degradation of iron regulatory protein 2 (IRP2). Here the authors show that FBXL5 and its regulation of IRP2 are required for HSC self-renewal and reconstitution capability.

Guardado en:

Detalles Bibliográficos
Autores principales:	Yoshiharu Muto, Masaaki Nishiyama, Akihiro Nita, Toshiro Moroishi, Keiichi I. Nakayama
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/32b1e866594148d596b3568030113e20
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:32b1e866594148d596b3568030113e20
record_format	dspace
spelling	oai:doaj.org-article:32b1e866594148d596b3568030113e202021-12-02T14:42:20ZEssential role of FBXL5-mediated cellular iron homeostasis in maintenance of hematopoietic stem cells10.1038/ncomms161142041-1723https://doaj.org/article/32b1e866594148d596b3568030113e202017-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms16114https://doaj.org/toc/2041-1723The iron-regulated F-box protein FBXL5 regulates iron homeostasis by mediating the degradation of iron regulatory protein 2 (IRP2). Here the authors show that FBXL5 and its regulation of IRP2 are required for HSC self-renewal and reconstitution capability.Yoshiharu MutoMasaaki NishiyamaAkihiro NitaToshiro MoroishiKeiichi I. NakayamaNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yoshiharu Muto Masaaki Nishiyama Akihiro Nita Toshiro Moroishi Keiichi I. Nakayama Essential role of FBXL5-mediated cellular iron homeostasis in maintenance of hematopoietic stem cells
description	The iron-regulated F-box protein FBXL5 regulates iron homeostasis by mediating the degradation of iron regulatory protein 2 (IRP2). Here the authors show that FBXL5 and its regulation of IRP2 are required for HSC self-renewal and reconstitution capability.
format	article
author	Yoshiharu Muto Masaaki Nishiyama Akihiro Nita Toshiro Moroishi Keiichi I. Nakayama
author_facet	Yoshiharu Muto Masaaki Nishiyama Akihiro Nita Toshiro Moroishi Keiichi I. Nakayama
author_sort	Yoshiharu Muto
title	Essential role of FBXL5-mediated cellular iron homeostasis in maintenance of hematopoietic stem cells
title_short	Essential role of FBXL5-mediated cellular iron homeostasis in maintenance of hematopoietic stem cells
title_full	Essential role of FBXL5-mediated cellular iron homeostasis in maintenance of hematopoietic stem cells
title_fullStr	Essential role of FBXL5-mediated cellular iron homeostasis in maintenance of hematopoietic stem cells
title_full_unstemmed	Essential role of FBXL5-mediated cellular iron homeostasis in maintenance of hematopoietic stem cells
title_sort	essential role of fbxl5-mediated cellular iron homeostasis in maintenance of hematopoietic stem cells
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/32b1e866594148d596b3568030113e20
work_keys_str_mv	AT yoshiharumuto essentialroleoffbxl5mediatedcellularironhomeostasisinmaintenanceofhematopoieticstemcells AT masaakinishiyama essentialroleoffbxl5mediatedcellularironhomeostasisinmaintenanceofhematopoieticstemcells AT akihironita essentialroleoffbxl5mediatedcellularironhomeostasisinmaintenanceofhematopoieticstemcells AT toshiromoroishi essentialroleoffbxl5mediatedcellularironhomeostasisinmaintenanceofhematopoieticstemcells AT keiichiinakayama essentialroleoffbxl5mediatedcellularironhomeostasisinmaintenanceofhematopoieticstemcells
_version_	1718389681405558784

Essential role of FBXL5-mediated cellular iron homeostasis in maintenance of hematopoietic stem cells

Ejemplares similares