Plasma circulating cell-free mitochondrial DNA in depressive disorders.

<h4>Background</h4>Plasma circulating cell-free mitochondrial DNA (ccf-mtDNA) is an immunogenic molecule and a novel biomarker of psychiatric disorders. Some previous studies reported increased levels of ccf-mtDNA in unmedicated depression and recent suicide attempters, while other studi...

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Autores principales:	Johan Fernström, Lars Ohlsson, Marie Asp, Eva Lavant, Amanda Holck, Cécile Grudet, Åsa Westrin, Daniel Lindqvist
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/32b817a674a84feaa37f3d641f42546a
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spelling	oai:doaj.org-article:32b817a674a84feaa37f3d641f42546a2021-12-02T20:04:18ZPlasma circulating cell-free mitochondrial DNA in depressive disorders.1932-620310.1371/journal.pone.0259591https://doaj.org/article/32b817a674a84feaa37f3d641f42546a2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0259591https://doaj.org/toc/1932-6203<h4>Background</h4>Plasma circulating cell-free mitochondrial DNA (ccf-mtDNA) is an immunogenic molecule and a novel biomarker of psychiatric disorders. Some previous studies reported increased levels of ccf-mtDNA in unmedicated depression and recent suicide attempters, while other studies found unchanged or decreased ccf-mtDNA levels in depression. Inconsistent findings across studies may be explained by small sample sizes and between-study variations in somatic and psychiatric co-morbidity or medication status.<h4>Methods</h4>We measured plasma ccf-mtDNA in a cohort of 281 patients with depressive disorders and 49 healthy controls. Ninety-three percent of all patients were treated with one or several psychotropic medications. Thirty-six percent had a personality disorder, 13% bipolar disorder. All analyses involving ccf-mtDNA were a priori adjusted for age and sex.<h4>Results</h4>Mean levels in ccf-mtDNA were significantly different between patients with a current depressive episode (n = 236), remitted depressive episode (n = 45) and healthy controls (n = 49) (f = 8.3, p<0.001). Post-hoc tests revealed that both patients with current (p<0.001) and remitted (p = 0.002) depression had lower ccf-mtDNA compared to controls. Within the depressed group there was a positive correlation between ccf-mtDNA and "inflammatory depression symptoms" (r = 0.15, p = 0.02). We also found that treatment with mood stabilizers lamotrigine, valproic acid or lithium was associated with lower ccf-mtDNA (f = 8.1, p = 0.005).<h4>Discussion</h4>Decreased plasma ccf-mtDNA in difficult-to-treat depression may be partly explained by concurrent psychotropic medications and co-morbidity. Our findings suggest that ccf-mtDNA may be differentially regulated in different subtypes of depression, and this hypothesis should be pursued in future studies.Johan FernströmLars OhlssonMarie AspEva LavantAmanda HolckCécile GrudetÅsa WestrinDaniel LindqvistPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11, p e0259591 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Johan Fernström Lars Ohlsson Marie Asp Eva Lavant Amanda Holck Cécile Grudet Åsa Westrin Daniel Lindqvist Plasma circulating cell-free mitochondrial DNA in depressive disorders.
description	<h4>Background</h4>Plasma circulating cell-free mitochondrial DNA (ccf-mtDNA) is an immunogenic molecule and a novel biomarker of psychiatric disorders. Some previous studies reported increased levels of ccf-mtDNA in unmedicated depression and recent suicide attempters, while other studies found unchanged or decreased ccf-mtDNA levels in depression. Inconsistent findings across studies may be explained by small sample sizes and between-study variations in somatic and psychiatric co-morbidity or medication status.<h4>Methods</h4>We measured plasma ccf-mtDNA in a cohort of 281 patients with depressive disorders and 49 healthy controls. Ninety-three percent of all patients were treated with one or several psychotropic medications. Thirty-six percent had a personality disorder, 13% bipolar disorder. All analyses involving ccf-mtDNA were a priori adjusted for age and sex.<h4>Results</h4>Mean levels in ccf-mtDNA were significantly different between patients with a current depressive episode (n = 236), remitted depressive episode (n = 45) and healthy controls (n = 49) (f = 8.3, p<0.001). Post-hoc tests revealed that both patients with current (p<0.001) and remitted (p = 0.002) depression had lower ccf-mtDNA compared to controls. Within the depressed group there was a positive correlation between ccf-mtDNA and "inflammatory depression symptoms" (r = 0.15, p = 0.02). We also found that treatment with mood stabilizers lamotrigine, valproic acid or lithium was associated with lower ccf-mtDNA (f = 8.1, p = 0.005).<h4>Discussion</h4>Decreased plasma ccf-mtDNA in difficult-to-treat depression may be partly explained by concurrent psychotropic medications and co-morbidity. Our findings suggest that ccf-mtDNA may be differentially regulated in different subtypes of depression, and this hypothesis should be pursued in future studies.
format	article
author	Johan Fernström Lars Ohlsson Marie Asp Eva Lavant Amanda Holck Cécile Grudet Åsa Westrin Daniel Lindqvist
author_facet	Johan Fernström Lars Ohlsson Marie Asp Eva Lavant Amanda Holck Cécile Grudet Åsa Westrin Daniel Lindqvist
author_sort	Johan Fernström
title	Plasma circulating cell-free mitochondrial DNA in depressive disorders.
title_short	Plasma circulating cell-free mitochondrial DNA in depressive disorders.
title_full	Plasma circulating cell-free mitochondrial DNA in depressive disorders.
title_fullStr	Plasma circulating cell-free mitochondrial DNA in depressive disorders.
title_full_unstemmed	Plasma circulating cell-free mitochondrial DNA in depressive disorders.
title_sort	plasma circulating cell-free mitochondrial dna in depressive disorders.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/32b817a674a84feaa37f3d641f42546a
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Plasma circulating cell-free mitochondrial DNA in depressive disorders.

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