INDUCTION OF IL-8 PRODUCTION BY THE METAL COMPLEXES OF γ-GLOBULIN FORMED WITH ZINC IONS
Abstract. This study has shown detectable production of IL-8, as a fraction of cytokine pool induced in culture of human peripheral blood cells (PBCs). Mean amounts of IL8 produced in presence of γ-globulin fraction proteins and/or their metal complexes with zinc ions varied from 575.0±27.77 to 6355...
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| Main Authors: | , , , |
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| Format: | article |
| Language: | RU |
| Published: |
SPb RAACI
2014
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| Subjects: | |
| Online Access: | https://doaj.org/article/32b8305179e04f3fa24ee3d3d8f07523 |
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| Summary: | Abstract. This study has shown detectable production of IL-8, as a fraction of cytokine pool induced in culture of human peripheral blood cells (PBCs). Mean amounts of IL8 produced in presence of γ-globulin fraction proteins and/or their metal complexes with zinc ions varied from 575.0±27.77 to 6355.0±480.98 pg/ ml. The complexes of γ-globulin with zinc (48 h of culture) caused increase of IL-8 production that was 1.8-fold higher than with control γ-globulin and 1.4-fold higher than with of zinc ions alone (p < 0.02). Dynamic tracking of the cytokine levels has shown that PBCs induced with γ-globulin/metal complexes produced IL8 as a factor of prolonged or late-type response. |
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