INDUCTION OF IL-8 PRODUCTION BY THE METAL COMPLEXES OF γ-GLOBULIN FORMED WITH ZINC IONS

Abstract. This study has shown detectable production of IL-8, as a fraction of cytokine pool induced in culture of human peripheral blood cells (PBCs). Mean amounts of IL8 produced in presence of γ-globulin fraction proteins and/or their metal complexes with zinc ions varied from 575.0±27.77 to 6355...

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Autores principales:	M. A. Apresova, I. E. Efremova, A. A. Babayants, S. B. Cheknev
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	γ-globulin metal complexes induction il-8 Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/32b8305179e04f3fa24ee3d3d8f07523
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spelling	oai:doaj.org-article:32b8305179e04f3fa24ee3d3d8f075232021-11-18T08:03:43ZINDUCTION OF IL-8 PRODUCTION BY THE METAL COMPLEXES OF γ-GLOBULIN FORMED WITH ZINC IONS1563-06252313-741X10.15789/1563-0625-2013-5-431-438https://doaj.org/article/32b8305179e04f3fa24ee3d3d8f075232014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/659https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. This study has shown detectable production of IL-8, as a fraction of cytokine pool induced in culture of human peripheral blood cells (PBCs). Mean amounts of IL8 produced in presence of γ-globulin fraction proteins and/or their metal complexes with zinc ions varied from 575.0±27.77 to 6355.0±480.98 pg/ ml. The complexes of γ-globulin with zinc (48 h of culture) caused increase of IL-8 production that was 1.8-fold higher than with control γ-globulin and 1.4-fold higher than with of zinc ions alone (p < 0.02). Dynamic tracking of the cytokine levels has shown that PBCs induced with γ-globulin/metal complexes produced IL8 as a factor of prolonged or late-type response.M. A. ApresovaI. E. EfremovaA. A. BabayantsS. B. CheknevSPb RAACIarticleγ-globulinmetal complexesinductionil-8Immunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 15, Iss 5, Pp 431-438 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	γ-globulin metal complexes induction il-8 Immunologic diseases. Allergy RC581-607
spellingShingle	γ-globulin metal complexes induction il-8 Immunologic diseases. Allergy RC581-607 M. A. Apresova I. E. Efremova A. A. Babayants S. B. Cheknev INDUCTION OF IL-8 PRODUCTION BY THE METAL COMPLEXES OF γ-GLOBULIN FORMED WITH ZINC IONS
description	Abstract. This study has shown detectable production of IL-8, as a fraction of cytokine pool induced in culture of human peripheral blood cells (PBCs). Mean amounts of IL8 produced in presence of γ-globulin fraction proteins and/or their metal complexes with zinc ions varied from 575.0±27.77 to 6355.0±480.98 pg/ ml. The complexes of γ-globulin with zinc (48 h of culture) caused increase of IL-8 production that was 1.8-fold higher than with control γ-globulin and 1.4-fold higher than with of zinc ions alone (p < 0.02). Dynamic tracking of the cytokine levels has shown that PBCs induced with γ-globulin/metal complexes produced IL8 as a factor of prolonged or late-type response.
format	article
author	M. A. Apresova I. E. Efremova A. A. Babayants S. B. Cheknev
author_facet	M. A. Apresova I. E. Efremova A. A. Babayants S. B. Cheknev
author_sort	M. A. Apresova
title	INDUCTION OF IL-8 PRODUCTION BY THE METAL COMPLEXES OF γ-GLOBULIN FORMED WITH ZINC IONS
title_short	INDUCTION OF IL-8 PRODUCTION BY THE METAL COMPLEXES OF γ-GLOBULIN FORMED WITH ZINC IONS
title_full	INDUCTION OF IL-8 PRODUCTION BY THE METAL COMPLEXES OF γ-GLOBULIN FORMED WITH ZINC IONS
title_fullStr	INDUCTION OF IL-8 PRODUCTION BY THE METAL COMPLEXES OF γ-GLOBULIN FORMED WITH ZINC IONS
title_full_unstemmed	INDUCTION OF IL-8 PRODUCTION BY THE METAL COMPLEXES OF γ-GLOBULIN FORMED WITH ZINC IONS
title_sort	induction of il-8 production by the metal complexes of γ-globulin formed with zinc ions
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/32b8305179e04f3fa24ee3d3d8f07523
work_keys_str_mv	AT maapresova inductionofil8productionbythemetalcomplexesofgglobulinformedwithzincions AT ieefremova inductionofil8productionbythemetalcomplexesofgglobulinformedwithzincions AT aababayants inductionofil8productionbythemetalcomplexesofgglobulinformedwithzincions AT sbcheknev inductionofil8productionbythemetalcomplexesofgglobulinformedwithzincions
_version_	1718422407860977664

INDUCTION OF IL-8 PRODUCTION BY THE METAL COMPLEXES OF γ-GLOBULIN FORMED WITH ZINC IONS

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