Risk factors for unfavorable clinical outcomes in patients with brain abscess in South Korea.

<h4>Background</h4>Brain abscess can be life-threatening and manifest various neurological findings, although the mortality rate has decreased recently. We investigated the risk factors for unfavorable outcomes of patients with brain abscess.<h4>Methods</h4>A retrospective co...

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Autores principales:	Yun Suk Cho, Yu Jin Sohn, Jong Hoon Hyun, Yae Jee Baek, Moo Hyun Kim, Jung Ho Kim, Jin Young Ahn, Su Jin Jeong, Nam Su Ku, Jun Yong Choi, Joon-Sup Yeom, Young Goo Song
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/32b85752e94047a385af22f2ae24a186
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spelling	oai:doaj.org-article:32b85752e94047a385af22f2ae24a1862021-12-02T20:14:30ZRisk factors for unfavorable clinical outcomes in patients with brain abscess in South Korea.1932-620310.1371/journal.pone.0257541https://doaj.org/article/32b85752e94047a385af22f2ae24a1862021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0257541https://doaj.org/toc/1932-6203<h4>Background</h4>Brain abscess can be life-threatening and manifest various neurological findings, although the mortality rate has decreased recently. We investigated the risk factors for unfavorable outcomes of patients with brain abscess.<h4>Methods</h4>A retrospective cohort study examined patients with brain abscess seen from May 2005 to December 2018 in a tertiary care hospital in Seoul, South Korea. We reviewed the medical records for clinical findings, therapeutic modalities, and prognostic factors of brain abscess. Unfavorable clinical outcomes were defined as death, moderate to severe disability with neurological deficits, or vegetative state at 1 year or at the time of discharge from outpatient follow-up.<h4>Results</h4>The study enrolled 135 patients: 65.2% were males; the mean age was 56 years. 35.6% had unfavorable outcomes. In multivariate analysis, higher Sequential Organ Failure Assessment (SOFA) (p < 0.001), pre-existing hemiplegia (p = 0.049), and higher Charlson comorbidity index (CCI) (p = 0.028) were independently associated with unfavorable outcomes.<h4>Conclusions</h4>Higher SOFA, pre-existing hemiplegia and higher Charlson comorbidity index were significant risk factors for unfavorable clinical outcomes in patients with brain abscess.Yun Suk ChoYu Jin SohnJong Hoon HyunYae Jee BaekMoo Hyun KimJung Ho KimJin Young AhnSu Jin JeongNam Su KuJun Yong ChoiJoon-Sup YeomYoung Goo SongPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 9, p e0257541 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yun Suk Cho Yu Jin Sohn Jong Hoon Hyun Yae Jee Baek Moo Hyun Kim Jung Ho Kim Jin Young Ahn Su Jin Jeong Nam Su Ku Jun Yong Choi Joon-Sup Yeom Young Goo Song Risk factors for unfavorable clinical outcomes in patients with brain abscess in South Korea.
description	<h4>Background</h4>Brain abscess can be life-threatening and manifest various neurological findings, although the mortality rate has decreased recently. We investigated the risk factors for unfavorable outcomes of patients with brain abscess.<h4>Methods</h4>A retrospective cohort study examined patients with brain abscess seen from May 2005 to December 2018 in a tertiary care hospital in Seoul, South Korea. We reviewed the medical records for clinical findings, therapeutic modalities, and prognostic factors of brain abscess. Unfavorable clinical outcomes were defined as death, moderate to severe disability with neurological deficits, or vegetative state at 1 year or at the time of discharge from outpatient follow-up.<h4>Results</h4>The study enrolled 135 patients: 65.2% were males; the mean age was 56 years. 35.6% had unfavorable outcomes. In multivariate analysis, higher Sequential Organ Failure Assessment (SOFA) (p < 0.001), pre-existing hemiplegia (p = 0.049), and higher Charlson comorbidity index (CCI) (p = 0.028) were independently associated with unfavorable outcomes.<h4>Conclusions</h4>Higher SOFA, pre-existing hemiplegia and higher Charlson comorbidity index were significant risk factors for unfavorable clinical outcomes in patients with brain abscess.
format	article
author	Yun Suk Cho Yu Jin Sohn Jong Hoon Hyun Yae Jee Baek Moo Hyun Kim Jung Ho Kim Jin Young Ahn Su Jin Jeong Nam Su Ku Jun Yong Choi Joon-Sup Yeom Young Goo Song
author_facet	Yun Suk Cho Yu Jin Sohn Jong Hoon Hyun Yae Jee Baek Moo Hyun Kim Jung Ho Kim Jin Young Ahn Su Jin Jeong Nam Su Ku Jun Yong Choi Joon-Sup Yeom Young Goo Song
author_sort	Yun Suk Cho
title	Risk factors for unfavorable clinical outcomes in patients with brain abscess in South Korea.
title_short	Risk factors for unfavorable clinical outcomes in patients with brain abscess in South Korea.
title_full	Risk factors for unfavorable clinical outcomes in patients with brain abscess in South Korea.
title_fullStr	Risk factors for unfavorable clinical outcomes in patients with brain abscess in South Korea.
title_full_unstemmed	Risk factors for unfavorable clinical outcomes in patients with brain abscess in South Korea.
title_sort	risk factors for unfavorable clinical outcomes in patients with brain abscess in south korea.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/32b85752e94047a385af22f2ae24a186
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Risk factors for unfavorable clinical outcomes in patients with brain abscess in South Korea.

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