Case Report: Repeated Series of Ketamine Infusions in Patients With Treatment-Resistant Depression: Presentation of Five Cases

Purpose: Approximately 30% of patients with major depressive disorder (MDD) are treatment resistant. There is an unquestionable need for new treatment strategies. Subanesthetic doses of intravenous (IV) ketamine have a rapid antidepressant effect in treatment-resistant depression (TRD). This paper d...

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Autores principales:	Maria Gałuszko-Wȩgielnik, Adam Włodarczyk, Wiesław Jerzy Cubała, Alina Wilkowska, Natalia Górska, Jakub Słupski
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	treatment-resistant depression ketamine treatment response multiple administrations transformative treatment Psychiatry RC435-571
Acceso en línea:	https://doaj.org/article/32bae4a593b64cee95bf4471b5209d28
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spelling	oai:doaj.org-article:32bae4a593b64cee95bf4471b5209d282021-12-02T08:50:35ZCase Report: Repeated Series of Ketamine Infusions in Patients With Treatment-Resistant Depression: Presentation of Five Cases1664-064010.3389/fpsyt.2021.705190https://doaj.org/article/32bae4a593b64cee95bf4471b5209d282021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fpsyt.2021.705190/fullhttps://doaj.org/toc/1664-0640Purpose: Approximately 30% of patients with major depressive disorder (MDD) are treatment resistant. There is an unquestionable need for new treatment strategies. Subanesthetic doses of intravenous (IV) ketamine have a rapid antidepressant effect in treatment-resistant depression (TRD). This paper describes the efficacy of repeated series of intravenous ketamine infusions as an add-on treatment in five TRD inpatients.Methods: Eligible patients aged 43–63 were given eight ketamine infusions as an add-on treatment for patients with MDD. The subjects have readministered the intervention due to worsening depressive symptoms.Results: Of the five inpatients given ketamine as a series of eight infusions, one underwent three, and four had two treatment series. Four patients achieved remission after first series and three after the second series of ketamine infusions. The adverse reactions were mild and transient with no sequelae.Limitations: Presented case series applies to short-term intervention with IV ketamine as an add-on therapy. The results cannot be generalized to the long-term maintenance treatment nor other ketamine formulations as well as different administration schedules and dosing.Conclusions: This case series showed efficacy and safety of the repeated series of IV ketamine treatment in TRD in MDD and bipolar disorder type I. The subsequent interventions were safe and observed adverse events were mild and transient. Interestingly, the IV ketamine treatment at successive administrations seems to alter the major depression severity of the next affective episode. There is a critical need for further research regarding IV ketamine treatment effectiveness and long-term safety in future studies.Maria Gałuszko-WȩgielnikAdam WłodarczykWiesław Jerzy CubałaAlina WilkowskaNatalia GórskaJakub SłupskiFrontiers Media S.A.articletreatment-resistant depressionketaminetreatment responsemultiple administrationstransformative treatmentPsychiatryRC435-571ENFrontiers in Psychiatry, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	treatment-resistant depression ketamine treatment response multiple administrations transformative treatment Psychiatry RC435-571
spellingShingle	treatment-resistant depression ketamine treatment response multiple administrations transformative treatment Psychiatry RC435-571 Maria Gałuszko-Wȩgielnik Adam Włodarczyk Wiesław Jerzy Cubała Alina Wilkowska Natalia Górska Jakub Słupski Case Report: Repeated Series of Ketamine Infusions in Patients With Treatment-Resistant Depression: Presentation of Five Cases
description	Purpose: Approximately 30% of patients with major depressive disorder (MDD) are treatment resistant. There is an unquestionable need for new treatment strategies. Subanesthetic doses of intravenous (IV) ketamine have a rapid antidepressant effect in treatment-resistant depression (TRD). This paper describes the efficacy of repeated series of intravenous ketamine infusions as an add-on treatment in five TRD inpatients.Methods: Eligible patients aged 43–63 were given eight ketamine infusions as an add-on treatment for patients with MDD. The subjects have readministered the intervention due to worsening depressive symptoms.Results: Of the five inpatients given ketamine as a series of eight infusions, one underwent three, and four had two treatment series. Four patients achieved remission after first series and three after the second series of ketamine infusions. The adverse reactions were mild and transient with no sequelae.Limitations: Presented case series applies to short-term intervention with IV ketamine as an add-on therapy. The results cannot be generalized to the long-term maintenance treatment nor other ketamine formulations as well as different administration schedules and dosing.Conclusions: This case series showed efficacy and safety of the repeated series of IV ketamine treatment in TRD in MDD and bipolar disorder type I. The subsequent interventions were safe and observed adverse events were mild and transient. Interestingly, the IV ketamine treatment at successive administrations seems to alter the major depression severity of the next affective episode. There is a critical need for further research regarding IV ketamine treatment effectiveness and long-term safety in future studies.
format	article
author	Maria Gałuszko-Wȩgielnik Adam Włodarczyk Wiesław Jerzy Cubała Alina Wilkowska Natalia Górska Jakub Słupski
author_facet	Maria Gałuszko-Wȩgielnik Adam Włodarczyk Wiesław Jerzy Cubała Alina Wilkowska Natalia Górska Jakub Słupski
author_sort	Maria Gałuszko-Wȩgielnik
title	Case Report: Repeated Series of Ketamine Infusions in Patients With Treatment-Resistant Depression: Presentation of Five Cases
title_short	Case Report: Repeated Series of Ketamine Infusions in Patients With Treatment-Resistant Depression: Presentation of Five Cases
title_full	Case Report: Repeated Series of Ketamine Infusions in Patients With Treatment-Resistant Depression: Presentation of Five Cases
title_fullStr	Case Report: Repeated Series of Ketamine Infusions in Patients With Treatment-Resistant Depression: Presentation of Five Cases
title_full_unstemmed	Case Report: Repeated Series of Ketamine Infusions in Patients With Treatment-Resistant Depression: Presentation of Five Cases
title_sort	case report: repeated series of ketamine infusions in patients with treatment-resistant depression: presentation of five cases
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/32bae4a593b64cee95bf4471b5209d28
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Case Report: Repeated Series of Ketamine Infusions in Patients With Treatment-Resistant Depression: Presentation of Five Cases

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