Ischemia/Reperfusion Injury of Fatty Liver Is Protected by A2AR and Exacerbated by A1R Stimulation through Opposite Effects on ASK1 Activation

Hepatic ischemia/reperfusion injury (IRI) is aggravated by steatosis and is a main risk factor in fatty liver transplantation. Adenosine receptors (ARs) are emerging as therapeutic targets in liver diseases. By using cellular and in vivo systems of hepatic steatosis and IRI, here we evaluated the ef...

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Auteurs principaux: Elisa Alchera, Bangalore R. Chandrashekar, Nausicaa Clemente, Ester Borroni, Renzo Boldorini, Rita Carini
Format: article
Langue:EN
Publié: MDPI AG 2021
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Accès en ligne:https://doaj.org/article/32c3e3d1bb7b4b1e8ee659da66e56c9b
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