18F-THK5351 Positron Emission Tomography Imaging in Neurodegenerative Tauopathies

Introduction: We aimed to determine whether in vivo tau deposits and monoamine oxidase B (MAO-B) detection using 18F-THK5351 positron emission tomography (PET) can assist in the differential distribution in patients with corticobasal syndrome (CBS), progressive supranuclear palsy (PSP), and Alzheime...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Michinori Ezura, Akio Kikuchi, Nobuyuki Okamura, Aiko Ishiki, Takafumi Hasegawa, Ryuichi Harada, Shoichi Watanuki, Yoshihito Funaki, Kotaro Hiraoka, Toru Baba, Naoto Sugeno, Shun Yoshida, Junpei Kobayashi, Michiko Kobayashi, Ohito Tano, Shun Ishiyama, Takaaki Nakamura, Ichiro Nakashima, Shunji Mugikura, Ren Iwata, Yasuyuki Taki, Katsutoshi Furukawa, Hiroyuki Arai, Shozo Furumoto, Manabu Tashiro, Kazuhiko Yanai, Yukitsuka Kudo, Atsushi Takeda, Masashi Aoki
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	tau deposits 18F-THK5351 positron emission tomography (PET) corticobasal syndrome (CBS) Alzheimer’s disease (AD) tauopathy Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/32c907a418364c868797fbcc1c7cd9a0
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:32c907a418364c868797fbcc1c7cd9a0
record_format	dspace
spelling	oai:doaj.org-article:32c907a418364c868797fbcc1c7cd9a02021-12-01T13:07:25Z18F-THK5351 Positron Emission Tomography Imaging in Neurodegenerative Tauopathies1663-436510.3389/fnagi.2021.761010https://doaj.org/article/32c907a418364c868797fbcc1c7cd9a02021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnagi.2021.761010/fullhttps://doaj.org/toc/1663-4365Introduction: We aimed to determine whether in vivo tau deposits and monoamine oxidase B (MAO-B) detection using 18F-THK5351 positron emission tomography (PET) can assist in the differential distribution in patients with corticobasal syndrome (CBS), progressive supranuclear palsy (PSP), and Alzheimer’s disease (AD) and whether 18F-THK5351 retention of lesion sites in CBS and PSP can correlate with clinical parameters.Methods:18F-THK5351 PET was performed in 35 participants, including 7, 9, and 10 patients with CBS, PSP, and AD, respectively, and 9 age-matched normal controls. In CBS and PSP, cognitive and motor functions were assessed using the Montreal Cognitive Assessment, Addenbrooke’s Cognitive Examination–Revised, and Frontal Assessment Battery, Unified Parkinson’s Disease Rating Scale Motor Score, and PSP Rating Scale.Results:18F-THK5351 retention was observed in sites susceptible to disease-related pathologies in CBS, PSP, and AD. 18F-THK5351 uptake in the precentral gyrus clearly differentiated patients with CBS from those with PSP and AD. Furthermore, 18F-THK5351 uptake in the inferior temporal gyrus clearly differentiated patients with AD from those with CBS and PSP. Regional 18F-THK5351 retention was associated with the cognitive function in CBS and PSP.Conclusion: Measurement of the tau deposits and MAO-B density in the brain using 18F-THK5351 may be helpful for the differential diagnosis of tauopathies and for understanding disease stages.Michinori EzuraAkio KikuchiAkio KikuchiNobuyuki OkamuraNobuyuki OkamuraAiko IshikiAiko IshikiTakafumi HasegawaRyuichi HaradaShoichi WatanukiYoshihito FunakiKotaro HiraokaToru BabaNaoto SugenoShun YoshidaJunpei KobayashiMichiko KobayashiOhito TanoShun IshiyamaTakaaki NakamuraIchiro NakashimaIchiro NakashimaShunji MugikuraRen IwataYasuyuki TakiKatsutoshi FurukawaKatsutoshi FurukawaHiroyuki AraiShozo FurumotoManabu TashiroKazuhiko YanaiYukitsuka KudoAtsushi TakedaMasashi AokiFrontiers Media S.A.articletau deposits18F-THK5351positron emission tomography (PET)corticobasal syndrome (CBS)Alzheimer’s disease (AD)tauopathyNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Aging Neuroscience, Vol 13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	tau deposits 18F-THK5351 positron emission tomography (PET) corticobasal syndrome (CBS) Alzheimer’s disease (AD) tauopathy Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	tau deposits 18F-THK5351 positron emission tomography (PET) corticobasal syndrome (CBS) Alzheimer’s disease (AD) tauopathy Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Michinori Ezura Akio Kikuchi Akio Kikuchi Nobuyuki Okamura Nobuyuki Okamura Aiko Ishiki Aiko Ishiki Takafumi Hasegawa Ryuichi Harada Shoichi Watanuki Yoshihito Funaki Kotaro Hiraoka Toru Baba Naoto Sugeno Shun Yoshida Junpei Kobayashi Michiko Kobayashi Ohito Tano Shun Ishiyama Takaaki Nakamura Ichiro Nakashima Ichiro Nakashima Shunji Mugikura Ren Iwata Yasuyuki Taki Katsutoshi Furukawa Katsutoshi Furukawa Hiroyuki Arai Shozo Furumoto Manabu Tashiro Kazuhiko Yanai Yukitsuka Kudo Atsushi Takeda Masashi Aoki 18F-THK5351 Positron Emission Tomography Imaging in Neurodegenerative Tauopathies
description	Introduction: We aimed to determine whether in vivo tau deposits and monoamine oxidase B (MAO-B) detection using 18F-THK5351 positron emission tomography (PET) can assist in the differential distribution in patients with corticobasal syndrome (CBS), progressive supranuclear palsy (PSP), and Alzheimer’s disease (AD) and whether 18F-THK5351 retention of lesion sites in CBS and PSP can correlate with clinical parameters.Methods:18F-THK5351 PET was performed in 35 participants, including 7, 9, and 10 patients with CBS, PSP, and AD, respectively, and 9 age-matched normal controls. In CBS and PSP, cognitive and motor functions were assessed using the Montreal Cognitive Assessment, Addenbrooke’s Cognitive Examination–Revised, and Frontal Assessment Battery, Unified Parkinson’s Disease Rating Scale Motor Score, and PSP Rating Scale.Results:18F-THK5351 retention was observed in sites susceptible to disease-related pathologies in CBS, PSP, and AD. 18F-THK5351 uptake in the precentral gyrus clearly differentiated patients with CBS from those with PSP and AD. Furthermore, 18F-THK5351 uptake in the inferior temporal gyrus clearly differentiated patients with AD from those with CBS and PSP. Regional 18F-THK5351 retention was associated with the cognitive function in CBS and PSP.Conclusion: Measurement of the tau deposits and MAO-B density in the brain using 18F-THK5351 may be helpful for the differential diagnosis of tauopathies and for understanding disease stages.
format	article
author	Michinori Ezura Akio Kikuchi Akio Kikuchi Nobuyuki Okamura Nobuyuki Okamura Aiko Ishiki Aiko Ishiki Takafumi Hasegawa Ryuichi Harada Shoichi Watanuki Yoshihito Funaki Kotaro Hiraoka Toru Baba Naoto Sugeno Shun Yoshida Junpei Kobayashi Michiko Kobayashi Ohito Tano Shun Ishiyama Takaaki Nakamura Ichiro Nakashima Ichiro Nakashima Shunji Mugikura Ren Iwata Yasuyuki Taki Katsutoshi Furukawa Katsutoshi Furukawa Hiroyuki Arai Shozo Furumoto Manabu Tashiro Kazuhiko Yanai Yukitsuka Kudo Atsushi Takeda Masashi Aoki
author_facet	Michinori Ezura Akio Kikuchi Akio Kikuchi Nobuyuki Okamura Nobuyuki Okamura Aiko Ishiki Aiko Ishiki Takafumi Hasegawa Ryuichi Harada Shoichi Watanuki Yoshihito Funaki Kotaro Hiraoka Toru Baba Naoto Sugeno Shun Yoshida Junpei Kobayashi Michiko Kobayashi Ohito Tano Shun Ishiyama Takaaki Nakamura Ichiro Nakashima Ichiro Nakashima Shunji Mugikura Ren Iwata Yasuyuki Taki Katsutoshi Furukawa Katsutoshi Furukawa Hiroyuki Arai Shozo Furumoto Manabu Tashiro Kazuhiko Yanai Yukitsuka Kudo Atsushi Takeda Masashi Aoki
author_sort	Michinori Ezura
title	18F-THK5351 Positron Emission Tomography Imaging in Neurodegenerative Tauopathies
title_short	18F-THK5351 Positron Emission Tomography Imaging in Neurodegenerative Tauopathies
title_full	18F-THK5351 Positron Emission Tomography Imaging in Neurodegenerative Tauopathies
title_fullStr	18F-THK5351 Positron Emission Tomography Imaging in Neurodegenerative Tauopathies
title_full_unstemmed	18F-THK5351 Positron Emission Tomography Imaging in Neurodegenerative Tauopathies
title_sort	18f-thk5351 positron emission tomography imaging in neurodegenerative tauopathies
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/32c907a418364c868797fbcc1c7cd9a0
work_keys_str_mv	AT michinoriezura 18fthk5351positronemissiontomographyimaginginneurodegenerativetauopathies AT akiokikuchi 18fthk5351positronemissiontomographyimaginginneurodegenerativetauopathies AT akiokikuchi 18fthk5351positronemissiontomographyimaginginneurodegenerativetauopathies AT nobuyukiokamura 18fthk5351positronemissiontomographyimaginginneurodegenerativetauopathies AT nobuyukiokamura 18fthk5351positronemissiontomographyimaginginneurodegenerativetauopathies AT aikoishiki 18fthk5351positronemissiontomographyimaginginneurodegenerativetauopathies AT aikoishiki 18fthk5351positronemissiontomographyimaginginneurodegenerativetauopathies AT takafumihasegawa 18fthk5351positronemissiontomographyimaginginneurodegenerativetauopathies AT ryuichiharada 18fthk5351positronemissiontomographyimaginginneurodegenerativetauopathies AT shoichiwatanuki 18fthk5351positronemissiontomographyimaginginneurodegenerativetauopathies AT yoshihitofunaki 18fthk5351positronemissiontomographyimaginginneurodegenerativetauopathies AT kotarohiraoka 18fthk5351positronemissiontomographyimaginginneurodegenerativetauopathies AT torubaba 18fthk5351positronemissiontomographyimaginginneurodegenerativetauopathies AT naotosugeno 18fthk5351positronemissiontomographyimaginginneurodegenerativetauopathies AT shunyoshida 18fthk5351positronemissiontomographyimaginginneurodegenerativetauopathies AT junpeikobayashi 18fthk5351positronemissiontomographyimaginginneurodegenerativetauopathies AT michikokobayashi 18fthk5351positronemissiontomographyimaginginneurodegenerativetauopathies AT ohitotano 18fthk5351positronemissiontomographyimaginginneurodegenerativetauopathies AT shunishiyama 18fthk5351positronemissiontomographyimaginginneurodegenerativetauopathies AT takaakinakamura 18fthk5351positronemissiontomographyimaginginneurodegenerativetauopathies AT ichironakashima 18fthk5351positronemissiontomographyimaginginneurodegenerativetauopathies AT ichironakashima 18fthk5351positronemissiontomographyimaginginneurodegenerativetauopathies AT shunjimugikura 18fthk5351positronemissiontomographyimaginginneurodegenerativetauopathies AT reniwata 18fthk5351positronemissiontomographyimaginginneurodegenerativetauopathies AT yasuyukitaki 18fthk5351positronemissiontomographyimaginginneurodegenerativetauopathies AT katsutoshifurukawa 18fthk5351positronemissiontomographyimaginginneurodegenerativetauopathies AT katsutoshifurukawa 18fthk5351positronemissiontomographyimaginginneurodegenerativetauopathies AT hiroyukiarai 18fthk5351positronemissiontomographyimaginginneurodegenerativetauopathies AT shozofurumoto 18fthk5351positronemissiontomographyimaginginneurodegenerativetauopathies AT manabutashiro 18fthk5351positronemissiontomographyimaginginneurodegenerativetauopathies AT kazuhikoyanai 18fthk5351positronemissiontomographyimaginginneurodegenerativetauopathies AT yukitsukakudo 18fthk5351positronemissiontomographyimaginginneurodegenerativetauopathies AT atsushitakeda 18fthk5351positronemissiontomographyimaginginneurodegenerativetauopathies AT masashiaoki 18fthk5351positronemissiontomographyimaginginneurodegenerativetauopathies
_version_	1718405166203404288

18F-THK5351 Positron Emission Tomography Imaging in Neurodegenerative Tauopathies

Ejemplares similares