Primary aldosteronism is associated with risk of urinary bladder stones in a nationwide cohort study

Abstract We analyzed database from the Taiwan National Health Insurance to investigate whether primary aldosteronism (PA) increases the risk of bladder stones. This retrospective nationwide population-based cohort study during the period of 1998–2011 compared patients with and without PA extracted b...

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Autores principales:	Mu-Chi Chung, Cheng-Li Lin, Ming-Ju Wu, Cheng-Hsu Chen, Jeng-Jer Shieh, Chi-Jung Chung, Chi-Yuan Li, Tung-Min Yu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/32cc3d652c9d445ebb2867967ee30ffb
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spelling	oai:doaj.org-article:32cc3d652c9d445ebb2867967ee30ffb2021-12-02T14:17:19ZPrimary aldosteronism is associated with risk of urinary bladder stones in a nationwide cohort study10.1038/s41598-021-86749-32045-2322https://doaj.org/article/32cc3d652c9d445ebb2867967ee30ffb2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86749-3https://doaj.org/toc/2045-2322Abstract We analyzed database from the Taiwan National Health Insurance to investigate whether primary aldosteronism (PA) increases the risk of bladder stones. This retrospective nationwide population-based cohort study during the period of 1998–2011 compared patients with and without PA extracted by propensity score matching. Cox proportional hazard models and competing death risk model were used to estimate the hazard ratios (HRs), sub-hazard ratios (SHRs) and corresponding 95% confidence intervals (CIs). There were 3442 patients with PA and 3442 patients without PA. The incidence rate of bladder stones was 5.36 and 3.76 per 1000 person-years for both groups, respectively. In adjusted Cox hazard proportional regression models, the HR of bladder stones was 1.68 (95% CI 1.20–2.34) for patients with PA compared to individuals without PA. Considering the competing risk of death, the SHR of bladder stones still indicates a higher risk for PA than a comparison cohort (SHR, 1.79; 95% CI 1.30–2.44). PA, age, sex, and fracture number were the variables significantly contributing to the formation of bladder stones. In conclusion, PA is significantly associated with risk of bladder stones.Mu-Chi ChungCheng-Li LinMing-Ju WuCheng-Hsu ChenJeng-Jer ShiehChi-Jung ChungChi-Yuan LiTung-Min YuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mu-Chi Chung Cheng-Li Lin Ming-Ju Wu Cheng-Hsu Chen Jeng-Jer Shieh Chi-Jung Chung Chi-Yuan Li Tung-Min Yu Primary aldosteronism is associated with risk of urinary bladder stones in a nationwide cohort study
description	Abstract We analyzed database from the Taiwan National Health Insurance to investigate whether primary aldosteronism (PA) increases the risk of bladder stones. This retrospective nationwide population-based cohort study during the period of 1998–2011 compared patients with and without PA extracted by propensity score matching. Cox proportional hazard models and competing death risk model were used to estimate the hazard ratios (HRs), sub-hazard ratios (SHRs) and corresponding 95% confidence intervals (CIs). There were 3442 patients with PA and 3442 patients without PA. The incidence rate of bladder stones was 5.36 and 3.76 per 1000 person-years for both groups, respectively. In adjusted Cox hazard proportional regression models, the HR of bladder stones was 1.68 (95% CI 1.20–2.34) for patients with PA compared to individuals without PA. Considering the competing risk of death, the SHR of bladder stones still indicates a higher risk for PA than a comparison cohort (SHR, 1.79; 95% CI 1.30–2.44). PA, age, sex, and fracture number were the variables significantly contributing to the formation of bladder stones. In conclusion, PA is significantly associated with risk of bladder stones.
format	article
author	Mu-Chi Chung Cheng-Li Lin Ming-Ju Wu Cheng-Hsu Chen Jeng-Jer Shieh Chi-Jung Chung Chi-Yuan Li Tung-Min Yu
author_facet	Mu-Chi Chung Cheng-Li Lin Ming-Ju Wu Cheng-Hsu Chen Jeng-Jer Shieh Chi-Jung Chung Chi-Yuan Li Tung-Min Yu
author_sort	Mu-Chi Chung
title	Primary aldosteronism is associated with risk of urinary bladder stones in a nationwide cohort study
title_short	Primary aldosteronism is associated with risk of urinary bladder stones in a nationwide cohort study
title_full	Primary aldosteronism is associated with risk of urinary bladder stones in a nationwide cohort study
title_fullStr	Primary aldosteronism is associated with risk of urinary bladder stones in a nationwide cohort study
title_full_unstemmed	Primary aldosteronism is associated with risk of urinary bladder stones in a nationwide cohort study
title_sort	primary aldosteronism is associated with risk of urinary bladder stones in a nationwide cohort study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/32cc3d652c9d445ebb2867967ee30ffb
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Primary aldosteronism is associated with risk of urinary bladder stones in a nationwide cohort study

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