Assessing SARS-CoV-2 Vertical Transmission and Neonatal Complications

We designed and implemented a prospective study to analyze the maternal and neonatal outcomes associated with COVID-19 and determine the likelihood of viral transmission to the fetus and newborn by collecting samples from amniotic fluid, placenta, umbilical cord blood, and breast milk. The study fol...

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Autores principales:	Cosmin Citu, Radu Neamtu, Virgiliu-Bogdan Sorop, Delia Ioana Horhat, Florin Gorun, Emanuela Tudorache, Oana Maria Gorun, Aris Boarta, Ioana Tuta-Sas, Ioana Mihaela Citu
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	SARS-CoV-2 COVID-19 pregnancy intrauterine infections vertical transmission Medicine R
Acceso en línea:	https://doaj.org/article/32cd0820f3f24008b93fdbbfa0dde8ae
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spelling	oai:doaj.org-article:32cd0820f3f24008b93fdbbfa0dde8ae2021-11-25T18:00:53ZAssessing SARS-CoV-2 Vertical Transmission and Neonatal Complications10.3390/jcm102252532077-0383https://doaj.org/article/32cd0820f3f24008b93fdbbfa0dde8ae2021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/22/5253https://doaj.org/toc/2077-0383We designed and implemented a prospective study to analyze the maternal and neonatal outcomes associated with COVID-19 and determine the likelihood of viral transmission to the fetus and newborn by collecting samples from amniotic fluid, placenta, umbilical cord blood, and breast milk. The study followed a prospective observational design, starting in July 2020 and lasting for one year. A total of 889 pregnant women were routinely tested for SARS-CoV-2 infection in an outpatient setting at our clinic, using nasal swabs for PCR testing. A total of 76 women were diagnosed with COVID-19. The positive patients who accepted study enrollment were systematically analyzed by collecting weekly nasal, urine, fecal, and serum samples, including amniotic fluid, placenta, umbilical cord, and breast milk at hospital admission and postpartum. Mothers with COVID-19 were at a significantly higher risk of developing gestational hypertension and giving birth prematurely by c-section than the general pregnant population. Moreover, their mortality rates were substantially higher. Their newborns did not have negative outcomes, except for prematurity, and an insignificant number of newborns were infected with SARS-CoV-2 (5.4%). No amniotic fluid samples were positive for SARS-CoV-2, and only 1.01% of PCR tests from breast milk were confirmed positive. Based on these results, we support the idea that SARS-CoV-2 positive pregnant women do not expose their infants to an additional risk of infection via breastfeeding, close contact, or in-utero. Consequently, we do not support maternal–newborn separation at delivery since they do not seem to be at an increased risk of SARS-CoV-2 infection.Cosmin CituRadu NeamtuVirgiliu-Bogdan SoropDelia Ioana HorhatFlorin GorunEmanuela TudoracheOana Maria GorunAris BoartaIoana Tuta-SasIoana Mihaela CituMDPI AGarticleSARS-CoV-2COVID-19pregnancyintrauterine infectionsvertical transmissionMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5253, p 5253 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	SARS-CoV-2 COVID-19 pregnancy intrauterine infections vertical transmission Medicine R
spellingShingle	SARS-CoV-2 COVID-19 pregnancy intrauterine infections vertical transmission Medicine R Cosmin Citu Radu Neamtu Virgiliu-Bogdan Sorop Delia Ioana Horhat Florin Gorun Emanuela Tudorache Oana Maria Gorun Aris Boarta Ioana Tuta-Sas Ioana Mihaela Citu Assessing SARS-CoV-2 Vertical Transmission and Neonatal Complications
description	We designed and implemented a prospective study to analyze the maternal and neonatal outcomes associated with COVID-19 and determine the likelihood of viral transmission to the fetus and newborn by collecting samples from amniotic fluid, placenta, umbilical cord blood, and breast milk. The study followed a prospective observational design, starting in July 2020 and lasting for one year. A total of 889 pregnant women were routinely tested for SARS-CoV-2 infection in an outpatient setting at our clinic, using nasal swabs for PCR testing. A total of 76 women were diagnosed with COVID-19. The positive patients who accepted study enrollment were systematically analyzed by collecting weekly nasal, urine, fecal, and serum samples, including amniotic fluid, placenta, umbilical cord, and breast milk at hospital admission and postpartum. Mothers with COVID-19 were at a significantly higher risk of developing gestational hypertension and giving birth prematurely by c-section than the general pregnant population. Moreover, their mortality rates were substantially higher. Their newborns did not have negative outcomes, except for prematurity, and an insignificant number of newborns were infected with SARS-CoV-2 (5.4%). No amniotic fluid samples were positive for SARS-CoV-2, and only 1.01% of PCR tests from breast milk were confirmed positive. Based on these results, we support the idea that SARS-CoV-2 positive pregnant women do not expose their infants to an additional risk of infection via breastfeeding, close contact, or in-utero. Consequently, we do not support maternal–newborn separation at delivery since they do not seem to be at an increased risk of SARS-CoV-2 infection.
format	article
author	Cosmin Citu Radu Neamtu Virgiliu-Bogdan Sorop Delia Ioana Horhat Florin Gorun Emanuela Tudorache Oana Maria Gorun Aris Boarta Ioana Tuta-Sas Ioana Mihaela Citu
author_facet	Cosmin Citu Radu Neamtu Virgiliu-Bogdan Sorop Delia Ioana Horhat Florin Gorun Emanuela Tudorache Oana Maria Gorun Aris Boarta Ioana Tuta-Sas Ioana Mihaela Citu
author_sort	Cosmin Citu
title	Assessing SARS-CoV-2 Vertical Transmission and Neonatal Complications
title_short	Assessing SARS-CoV-2 Vertical Transmission and Neonatal Complications
title_full	Assessing SARS-CoV-2 Vertical Transmission and Neonatal Complications
title_fullStr	Assessing SARS-CoV-2 Vertical Transmission and Neonatal Complications
title_full_unstemmed	Assessing SARS-CoV-2 Vertical Transmission and Neonatal Complications
title_sort	assessing sars-cov-2 vertical transmission and neonatal complications
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/32cd0820f3f24008b93fdbbfa0dde8ae
work_keys_str_mv	AT cosmincitu assessingsarscov2verticaltransmissionandneonatalcomplications AT raduneamtu assessingsarscov2verticaltransmissionandneonatalcomplications AT virgiliubogdansorop assessingsarscov2verticaltransmissionandneonatalcomplications AT deliaioanahorhat assessingsarscov2verticaltransmissionandneonatalcomplications AT floringorun assessingsarscov2verticaltransmissionandneonatalcomplications AT emanuelatudorache assessingsarscov2verticaltransmissionandneonatalcomplications AT oanamariagorun assessingsarscov2verticaltransmissionandneonatalcomplications AT arisboarta assessingsarscov2verticaltransmissionandneonatalcomplications AT ioanatutasas assessingsarscov2verticaltransmissionandneonatalcomplications AT ioanamihaelacitu assessingsarscov2verticaltransmissionandneonatalcomplications
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Assessing SARS-CoV-2 Vertical Transmission and Neonatal Complications

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