Prognostic value and predication model of microvascular invasion in patients with intrahepatic cholangiocarcinoma: a multicenter study from China

Abstract Background At present, hepatectomy is still the most common and effective treatment method for intrahepatic cholangiocarcinoma (ICC) patients. However, the postoperative prognosis is poor. Therefore, the prognostic factors for these patients require further exploration. Whether microvascula...

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Autores principales:	Yifan Chen, Hongzhi Liu, Jinyu Zhang, Yijun Wu, Weiping Zhou, Zhangjun Cheng, Jianying Lou, Shuguo Zheng, Xinyu Bi, Jianming Wang, Wei Guo, Fuyu Li, Jian Wang, Yamin Zheng, Jingdong Li, Shi Cheng, Yongyi Zeng, Jingfeng Liu
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Intrahepatic cholangiocarcinoma Microvascular invasion Prognosis Prediction model Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/32cfc0a4c70e4facb525196861705c47
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spelling	oai:doaj.org-article:32cfc0a4c70e4facb525196861705c472021-12-05T12:19:30ZPrognostic value and predication model of microvascular invasion in patients with intrahepatic cholangiocarcinoma: a multicenter study from China10.1186/s12885-021-09035-51471-2407https://doaj.org/article/32cfc0a4c70e4facb525196861705c472021-12-01T00:00:00Zhttps://doi.org/10.1186/s12885-021-09035-5https://doaj.org/toc/1471-2407Abstract Background At present, hepatectomy is still the most common and effective treatment method for intrahepatic cholangiocarcinoma (ICC) patients. However, the postoperative prognosis is poor. Therefore, the prognostic factors for these patients require further exploration. Whether microvascular invasion (MVI) plays a crucial role in the prognosis of ICC patients is still unclear. Moreover, few studies have focused on preoperative predictions of MVI in ICC patients. Methods Clinicopathological data of 704 ICC patients after curative resection were retrospectively collected from 13 hospitals. Independent risk factors were identified by the Cox or logistic proportional hazards model. In addition, the survival curves of the MVI-positive and MVI-negative groups before and after matching were analyzed. Subsequently, 341 patients from a single center (Eastern Hepatobiliary Hospital) in the above multicenter retrospective cohort were used to construct a nomogram prediction model. Then, the model was evaluated by the index of concordance (C-Index) and the calibration curve. Results After propensity score matching (PSM), Child-Pugh grade and MVI were independent risk factors for overall survival (OS) in ICC patients after curative resection. Major hepatectomy and MVI were independent risk factors for recurrence-free survival (RFS). The survival curves of OS and RFS before and after PSM in the MVI-positive groups were significantly different compared with those in the MVI-negative groups. Multivariate logistic regression results demonstrated that age, gamma-glutamyl transpeptidase (GGT), and preoperative image tumor number were independent risk factors for the occurrence of MVI. Furthermore, the prediction model in the form of a nomogram was constructed, which showed good prediction ability for both the training (C-index = 0.7622) and validation (C-index = 0.7591) groups, and the calibration curve showed good consistency with reality. Conclusion MVI is an independent risk factor for the prognosis of ICC patients after curative resection. Age, GGT, and preoperative image tumor number were independent risk factors for the occurrence of MVI in ICC patients. The prediction model constructed further showed good predictive ability in both the training and validation groups with good consistency with reality.Yifan ChenHongzhi LiuJinyu ZhangYijun WuWeiping ZhouZhangjun ChengJianying LouShuguo ZhengXinyu BiJianming WangWei GuoFuyu LiJian WangYamin ZhengJingdong LiShi ChengYongyi ZengJingfeng LiuBMCarticleIntrahepatic cholangiocarcinomaMicrovascular invasionPrognosisPrediction modelNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENBMC Cancer, Vol 21, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Intrahepatic cholangiocarcinoma Microvascular invasion Prognosis Prediction model Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Intrahepatic cholangiocarcinoma Microvascular invasion Prognosis Prediction model Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Yifan Chen Hongzhi Liu Jinyu Zhang Yijun Wu Weiping Zhou Zhangjun Cheng Jianying Lou Shuguo Zheng Xinyu Bi Jianming Wang Wei Guo Fuyu Li Jian Wang Yamin Zheng Jingdong Li Shi Cheng Yongyi Zeng Jingfeng Liu Prognostic value and predication model of microvascular invasion in patients with intrahepatic cholangiocarcinoma: a multicenter study from China
description	Abstract Background At present, hepatectomy is still the most common and effective treatment method for intrahepatic cholangiocarcinoma (ICC) patients. However, the postoperative prognosis is poor. Therefore, the prognostic factors for these patients require further exploration. Whether microvascular invasion (MVI) plays a crucial role in the prognosis of ICC patients is still unclear. Moreover, few studies have focused on preoperative predictions of MVI in ICC patients. Methods Clinicopathological data of 704 ICC patients after curative resection were retrospectively collected from 13 hospitals. Independent risk factors were identified by the Cox or logistic proportional hazards model. In addition, the survival curves of the MVI-positive and MVI-negative groups before and after matching were analyzed. Subsequently, 341 patients from a single center (Eastern Hepatobiliary Hospital) in the above multicenter retrospective cohort were used to construct a nomogram prediction model. Then, the model was evaluated by the index of concordance (C-Index) and the calibration curve. Results After propensity score matching (PSM), Child-Pugh grade and MVI were independent risk factors for overall survival (OS) in ICC patients after curative resection. Major hepatectomy and MVI were independent risk factors for recurrence-free survival (RFS). The survival curves of OS and RFS before and after PSM in the MVI-positive groups were significantly different compared with those in the MVI-negative groups. Multivariate logistic regression results demonstrated that age, gamma-glutamyl transpeptidase (GGT), and preoperative image tumor number were independent risk factors for the occurrence of MVI. Furthermore, the prediction model in the form of a nomogram was constructed, which showed good prediction ability for both the training (C-index = 0.7622) and validation (C-index = 0.7591) groups, and the calibration curve showed good consistency with reality. Conclusion MVI is an independent risk factor for the prognosis of ICC patients after curative resection. Age, GGT, and preoperative image tumor number were independent risk factors for the occurrence of MVI in ICC patients. The prediction model constructed further showed good predictive ability in both the training and validation groups with good consistency with reality.
format	article
author	Yifan Chen Hongzhi Liu Jinyu Zhang Yijun Wu Weiping Zhou Zhangjun Cheng Jianying Lou Shuguo Zheng Xinyu Bi Jianming Wang Wei Guo Fuyu Li Jian Wang Yamin Zheng Jingdong Li Shi Cheng Yongyi Zeng Jingfeng Liu
author_facet	Yifan Chen Hongzhi Liu Jinyu Zhang Yijun Wu Weiping Zhou Zhangjun Cheng Jianying Lou Shuguo Zheng Xinyu Bi Jianming Wang Wei Guo Fuyu Li Jian Wang Yamin Zheng Jingdong Li Shi Cheng Yongyi Zeng Jingfeng Liu
author_sort	Yifan Chen
title	Prognostic value and predication model of microvascular invasion in patients with intrahepatic cholangiocarcinoma: a multicenter study from China
title_short	Prognostic value and predication model of microvascular invasion in patients with intrahepatic cholangiocarcinoma: a multicenter study from China
title_full	Prognostic value and predication model of microvascular invasion in patients with intrahepatic cholangiocarcinoma: a multicenter study from China
title_fullStr	Prognostic value and predication model of microvascular invasion in patients with intrahepatic cholangiocarcinoma: a multicenter study from China
title_full_unstemmed	Prognostic value and predication model of microvascular invasion in patients with intrahepatic cholangiocarcinoma: a multicenter study from China
title_sort	prognostic value and predication model of microvascular invasion in patients with intrahepatic cholangiocarcinoma: a multicenter study from china
publisher	BMC
publishDate	2021
url	https://doaj.org/article/32cfc0a4c70e4facb525196861705c47
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Prognostic value and predication model of microvascular invasion in patients with intrahepatic cholangiocarcinoma: a multicenter study from China

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