Chemokine receptor expression on peripheral blood T-helper cells in Helicobacter pylori-associated diseases: chronic gastroduodenitis and peptic ulcer disease

Helicobacter pylori represents a pathogen causing chronic infection in around a half of the global human population, which manifestations vary from asymptomatic infection to developing gastritis and peptic ulcer. The data accumulated suggest that overt clinical types of this infection are associated...

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Autores principales:	V. Yu. Talayev, M. V. Talaeyva, E. V. Voronina, I. Ye. Zaichenko, N. V. Neumoina, K. M. Perfilova, O. N. Babaykina
Formato:	article
Lenguaje:	RU
Publicado:	Sankt-Peterburg : NIIÈM imeni Pastera 2019
Materias:	t lymphocytes chemokine receptors peptic ulcer disease gastritis duodenitis Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/32d3120df4774068a38e09b23546df5b
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spelling	oai:doaj.org-article:32d3120df4774068a38e09b23546df5b2021-11-22T07:09:52ZChemokine receptor expression on peripheral blood T-helper cells in Helicobacter pylori-associated diseases: chronic gastroduodenitis and peptic ulcer disease2220-76192313-739810.15789/2220-7619-2019-2-295-303https://doaj.org/article/32d3120df4774068a38e09b23546df5b2019-07-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/698https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398Helicobacter pylori represents a pathogen causing chronic infection in around a half of the global human population, which manifestations vary from asymptomatic infection to developing gastritis and peptic ulcer. The data accumulated suggest that overt clinical types of this infection are associated with lost immunoregulation and increased pro-inflammatory cell-mediated immune response triggered by H. pylori-specific T helper cells. Here, we examined the degree of peripheral blood CD4+ T cell maturity and related expression of chemokine receptors involved in migration to gastrointestinal tract (CCR9 and CCR6), as well as Тand B-cell zones of lymphoid organs (CCR7 and CXCR5). It was shown that overt H. pylori-infection was coupled to changes in expression pattern of chemokine receptors on T helper cells. In particular, percentage of mature CD4+CD45RO+ T cells bearing CCR9 and immature CD4+CD45RO– Т cells expressing CXCR5 was increased in peripheral blood of patients with chronic gastroduodenitis. However, increased amount of activated mature CD4+CD45RO+ICOS+ T cells was observed in patients with chronic gastroduodenitis comorbid with peptic ulcer that was also associated with elevated amount of mature CCR6+ T helpers (mainly CD4+CD45RO+CCR7– CCR6+ cells) and follicular T helper cells as well as emerging minor CD4+CD45RO+CXCR5+CCR6+.T cell subset, not affecting CD4+CCR9+ Т cells. Thus, the data obtained evidence that tissue-specific T-helper cell migration is controlled separately in of H. pylori-associated diseases.V. Yu. TalayevM. V. TalaeyvaE. V. VoroninaI. Ye. ZaichenkoN. V. NeumoinaK. M. PerfilovaO. N. BabaykinaSankt-Peterburg : NIIÈM imeni Pasteraarticlet lymphocyteschemokine receptorspeptic ulcer diseasegastritisduodenitisInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 9, Iss 2, Pp 295-303 (2019)
institution	DOAJ
collection	DOAJ
language	RU
topic	t lymphocytes chemokine receptors peptic ulcer disease gastritis duodenitis Infectious and parasitic diseases RC109-216
spellingShingle	t lymphocytes chemokine receptors peptic ulcer disease gastritis duodenitis Infectious and parasitic diseases RC109-216 V. Yu. Talayev M. V. Talaeyva E. V. Voronina I. Ye. Zaichenko N. V. Neumoina K. M. Perfilova O. N. Babaykina Chemokine receptor expression on peripheral blood T-helper cells in Helicobacter pylori-associated diseases: chronic gastroduodenitis and peptic ulcer disease
description	Helicobacter pylori represents a pathogen causing chronic infection in around a half of the global human population, which manifestations vary from asymptomatic infection to developing gastritis and peptic ulcer. The data accumulated suggest that overt clinical types of this infection are associated with lost immunoregulation and increased pro-inflammatory cell-mediated immune response triggered by H. pylori-specific T helper cells. Here, we examined the degree of peripheral blood CD4+ T cell maturity and related expression of chemokine receptors involved in migration to gastrointestinal tract (CCR9 and CCR6), as well as Тand B-cell zones of lymphoid organs (CCR7 and CXCR5). It was shown that overt H. pylori-infection was coupled to changes in expression pattern of chemokine receptors on T helper cells. In particular, percentage of mature CD4+CD45RO+ T cells bearing CCR9 and immature CD4+CD45RO– Т cells expressing CXCR5 was increased in peripheral blood of patients with chronic gastroduodenitis. However, increased amount of activated mature CD4+CD45RO+ICOS+ T cells was observed in patients with chronic gastroduodenitis comorbid with peptic ulcer that was also associated with elevated amount of mature CCR6+ T helpers (mainly CD4+CD45RO+CCR7– CCR6+ cells) and follicular T helper cells as well as emerging minor CD4+CD45RO+CXCR5+CCR6+.T cell subset, not affecting CD4+CCR9+ Т cells. Thus, the data obtained evidence that tissue-specific T-helper cell migration is controlled separately in of H. pylori-associated diseases.
format	article
author	V. Yu. Talayev M. V. Talaeyva E. V. Voronina I. Ye. Zaichenko N. V. Neumoina K. M. Perfilova O. N. Babaykina
author_facet	V. Yu. Talayev M. V. Talaeyva E. V. Voronina I. Ye. Zaichenko N. V. Neumoina K. M. Perfilova O. N. Babaykina
author_sort	V. Yu. Talayev
title	Chemokine receptor expression on peripheral blood T-helper cells in Helicobacter pylori-associated diseases: chronic gastroduodenitis and peptic ulcer disease
title_short	Chemokine receptor expression on peripheral blood T-helper cells in Helicobacter pylori-associated diseases: chronic gastroduodenitis and peptic ulcer disease
title_full	Chemokine receptor expression on peripheral blood T-helper cells in Helicobacter pylori-associated diseases: chronic gastroduodenitis and peptic ulcer disease
title_fullStr	Chemokine receptor expression on peripheral blood T-helper cells in Helicobacter pylori-associated diseases: chronic gastroduodenitis and peptic ulcer disease
title_full_unstemmed	Chemokine receptor expression on peripheral blood T-helper cells in Helicobacter pylori-associated diseases: chronic gastroduodenitis and peptic ulcer disease
title_sort	chemokine receptor expression on peripheral blood t-helper cells in helicobacter pylori-associated diseases: chronic gastroduodenitis and peptic ulcer disease
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2019
url	https://doaj.org/article/32d3120df4774068a38e09b23546df5b
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Chemokine receptor expression on peripheral blood T-helper cells in Helicobacter pylori-associated diseases: chronic gastroduodenitis and peptic ulcer disease

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