Biochemical Investigation of Therapeutic Potential of Resveratrol Against Arsenic Intoxication

Arsenic has been reported to cause damaging effects on different body organs. This study was designed to evaluate the protective effect of resveratrol (RSV) against arsenic trioxide (ATO)–induced intoxication in experimental animals. Twenty-four Wistar rats were allocated in 4 groups: group 1: contr...

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Autores principales:	Kanwal Irshad MPhil, Kanwal Rehman PhD, Muhammad Sajid Hamid Akash PhD, Iqbal Hussain PhD
Formato:	article
Lenguaje:	EN
Publicado:	SAGE Publishing 2021
Materias:	Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/32d65373f8054df9918fe649352dc846
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spelling	oai:doaj.org-article:32d65373f8054df9918fe649352dc8462021-12-01T23:34:25ZBiochemical Investigation of Therapeutic Potential of Resveratrol Against Arsenic Intoxication1559-325810.1177/15593258211060941https://doaj.org/article/32d65373f8054df9918fe649352dc8462021-11-01T00:00:00Zhttps://doi.org/10.1177/15593258211060941https://doaj.org/toc/1559-3258Arsenic has been reported to cause damaging effects on different body organs. This study was designed to evaluate the protective effect of resveratrol (RSV) against arsenic trioxide (ATO)–induced intoxication in experimental animals. Twenty-four Wistar rats were allocated in 4 groups: group 1: control group, received normal diet; group 2: received ATO (3 mg/kg); group 3: received RSV (8 mg/kg) 30 minutes before administration of ATO; and group 4: received ascorbic acid (25 mg/kg) 30 minutes before administration of ATO. Treatments were given to experimental rats daily for consecutive 8 days. At the end of experimental period, bioaccumulation of arsenic in liver and kidney was assessed by hydride generation-atomic absorption spectrophotometer to investigate the association of arsenic accumulation with histological aberrations. Following parameters were also investigated: serum biochemical profile (alanine aminotransferase, aspartate transaminase, alkaline phosphatase, blood urea nitrogen, and creatinine) for evaluation of liver and kidney functions and lipid peroxidation and oxidative stress (malondialdehyde, glutathione, superoxide dismutase, catalase, and glutathione peroxidase) in tissue homogenates of liver and kidney for estimation of oxidative status. The findings of this study indicate that RSV remarkably ameliorated the hepatic and renal toxicity in arsenic-exposed rat model due to its strong antioxidant potential.Kanwal Irshad MPhilKanwal Rehman PhDMuhammad Sajid Hamid Akash PhDIqbal Hussain PhDSAGE PublishingarticleTherapeutics. PharmacologyRM1-950ENDose-Response, Vol 19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Therapeutics. Pharmacology RM1-950
spellingShingle	Therapeutics. Pharmacology RM1-950 Kanwal Irshad MPhil Kanwal Rehman PhD Muhammad Sajid Hamid Akash PhD Iqbal Hussain PhD Biochemical Investigation of Therapeutic Potential of Resveratrol Against Arsenic Intoxication
description	Arsenic has been reported to cause damaging effects on different body organs. This study was designed to evaluate the protective effect of resveratrol (RSV) against arsenic trioxide (ATO)–induced intoxication in experimental animals. Twenty-four Wistar rats were allocated in 4 groups: group 1: control group, received normal diet; group 2: received ATO (3 mg/kg); group 3: received RSV (8 mg/kg) 30 minutes before administration of ATO; and group 4: received ascorbic acid (25 mg/kg) 30 minutes before administration of ATO. Treatments were given to experimental rats daily for consecutive 8 days. At the end of experimental period, bioaccumulation of arsenic in liver and kidney was assessed by hydride generation-atomic absorption spectrophotometer to investigate the association of arsenic accumulation with histological aberrations. Following parameters were also investigated: serum biochemical profile (alanine aminotransferase, aspartate transaminase, alkaline phosphatase, blood urea nitrogen, and creatinine) for evaluation of liver and kidney functions and lipid peroxidation and oxidative stress (malondialdehyde, glutathione, superoxide dismutase, catalase, and glutathione peroxidase) in tissue homogenates of liver and kidney for estimation of oxidative status. The findings of this study indicate that RSV remarkably ameliorated the hepatic and renal toxicity in arsenic-exposed rat model due to its strong antioxidant potential.
format	article
author	Kanwal Irshad MPhil Kanwal Rehman PhD Muhammad Sajid Hamid Akash PhD Iqbal Hussain PhD
author_facet	Kanwal Irshad MPhil Kanwal Rehman PhD Muhammad Sajid Hamid Akash PhD Iqbal Hussain PhD
author_sort	Kanwal Irshad MPhil
title	Biochemical Investigation of Therapeutic Potential of Resveratrol Against Arsenic Intoxication
title_short	Biochemical Investigation of Therapeutic Potential of Resveratrol Against Arsenic Intoxication
title_full	Biochemical Investigation of Therapeutic Potential of Resveratrol Against Arsenic Intoxication
title_fullStr	Biochemical Investigation of Therapeutic Potential of Resveratrol Against Arsenic Intoxication
title_full_unstemmed	Biochemical Investigation of Therapeutic Potential of Resveratrol Against Arsenic Intoxication
title_sort	biochemical investigation of therapeutic potential of resveratrol against arsenic intoxication
publisher	SAGE Publishing
publishDate	2021
url	https://doaj.org/article/32d65373f8054df9918fe649352dc846
work_keys_str_mv	AT kanwalirshadmphil biochemicalinvestigationoftherapeuticpotentialofresveratrolagainstarsenicintoxication AT kanwalrehmanphd biochemicalinvestigationoftherapeuticpotentialofresveratrolagainstarsenicintoxication AT muhammadsajidhamidakashphd biochemicalinvestigationoftherapeuticpotentialofresveratrolagainstarsenicintoxication AT iqbalhussainphd biochemicalinvestigationoftherapeuticpotentialofresveratrolagainstarsenicintoxication
_version_	1718403976323399680

Biochemical Investigation of Therapeutic Potential of Resveratrol Against Arsenic Intoxication

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