Crystal structures of APOBEC3G N-domain alone and its complex with DNA

The N-terminal domain of APOBEC3G (A3G) is required for anti-HIV activity, HIV-1 viral infectivity factor (Vif) binds to this domain of A3G to mediate its degradation. Here, the authors use their crystal structures of this A3G domain alone and bound to single-stranded DNA to investigate the molecula...

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Autores principales:	Xiao Xiao, Shu-Xing Li, Hanjing Yang, Xiaojiang S. Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/32db43472bcf4a808a00465614aed590
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spelling	oai:doaj.org-article:32db43472bcf4a808a00465614aed5902021-12-02T15:34:55ZCrystal structures of APOBEC3G N-domain alone and its complex with DNA10.1038/ncomms121932041-1723https://doaj.org/article/32db43472bcf4a808a00465614aed5902016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12193https://doaj.org/toc/2041-1723The N-terminal domain of APOBEC3G (A3G) is required for anti-HIV activity, HIV-1 viral infectivity factor (Vif) binds to this domain of A3G to mediate its degradation. Here, the authors use their crystal structures of this A3G domain alone and bound to single-stranded DNA to investigate the molecular details of this interaction.Xiao XiaoShu-Xing LiHanjing YangXiaojiang S. ChenNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xiao Xiao Shu-Xing Li Hanjing Yang Xiaojiang S. Chen Crystal structures of APOBEC3G N-domain alone and its complex with DNA
description	The N-terminal domain of APOBEC3G (A3G) is required for anti-HIV activity, HIV-1 viral infectivity factor (Vif) binds to this domain of A3G to mediate its degradation. Here, the authors use their crystal structures of this A3G domain alone and bound to single-stranded DNA to investigate the molecular details of this interaction.
format	article
author	Xiao Xiao Shu-Xing Li Hanjing Yang Xiaojiang S. Chen
author_facet	Xiao Xiao Shu-Xing Li Hanjing Yang Xiaojiang S. Chen
author_sort	Xiao Xiao
title	Crystal structures of APOBEC3G N-domain alone and its complex with DNA
title_short	Crystal structures of APOBEC3G N-domain alone and its complex with DNA
title_full	Crystal structures of APOBEC3G N-domain alone and its complex with DNA
title_fullStr	Crystal structures of APOBEC3G N-domain alone and its complex with DNA
title_full_unstemmed	Crystal structures of APOBEC3G N-domain alone and its complex with DNA
title_sort	crystal structures of apobec3g n-domain alone and its complex with dna
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/32db43472bcf4a808a00465614aed590
work_keys_str_mv	AT xiaoxiao crystalstructuresofapobec3gndomainaloneanditscomplexwithdna AT shuxingli crystalstructuresofapobec3gndomainaloneanditscomplexwithdna AT hanjingyang crystalstructuresofapobec3gndomainaloneanditscomplexwithdna AT xiaojiangschen crystalstructuresofapobec3gndomainaloneanditscomplexwithdna
_version_	1718386709344813056

Crystal structures of APOBEC3G N-domain alone and its complex with DNA

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