The Human LL-37(17-29) antimicrobial peptide reveals a functional supramolecular structure

The human antibacterial and immunomodulatory peptide LL-37 is a hCAP-18 protein cleavage product that self-assembles. Here, the authors present the human and gorilla LL-37 (17–29) crystal structures, revealing a self-assembly of amphipathic helices into a densely packed and elongated hexameric struc...

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Autores principales:	Yizhaq Engelberg, Meytal Landau
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/32dc3f228962462da03ce14896285cc7
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spelling	oai:doaj.org-article:32dc3f228962462da03ce14896285cc72021-12-02T18:49:27ZThe Human LL-37(17-29) antimicrobial peptide reveals a functional supramolecular structure10.1038/s41467-020-17736-x2041-1723https://doaj.org/article/32dc3f228962462da03ce14896285cc72020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17736-xhttps://doaj.org/toc/2041-1723The human antibacterial and immunomodulatory peptide LL-37 is a hCAP-18 protein cleavage product that self-assembles. Here, the authors present the human and gorilla LL-37 (17–29) crystal structures, revealing a self-assembly of amphipathic helices into a densely packed and elongated hexameric structure with a central pore and mutagenesis experiments support the role of self-assembly for antibacterial activity.Yizhaq EngelbergMeytal LandauNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yizhaq Engelberg Meytal Landau The Human LL-37(17-29) antimicrobial peptide reveals a functional supramolecular structure
description	The human antibacterial and immunomodulatory peptide LL-37 is a hCAP-18 protein cleavage product that self-assembles. Here, the authors present the human and gorilla LL-37 (17–29) crystal structures, revealing a self-assembly of amphipathic helices into a densely packed and elongated hexameric structure with a central pore and mutagenesis experiments support the role of self-assembly for antibacterial activity.
format	article
author	Yizhaq Engelberg Meytal Landau
author_facet	Yizhaq Engelberg Meytal Landau
author_sort	Yizhaq Engelberg
title	The Human LL-37(17-29) antimicrobial peptide reveals a functional supramolecular structure
title_short	The Human LL-37(17-29) antimicrobial peptide reveals a functional supramolecular structure
title_full	The Human LL-37(17-29) antimicrobial peptide reveals a functional supramolecular structure
title_fullStr	The Human LL-37(17-29) antimicrobial peptide reveals a functional supramolecular structure
title_full_unstemmed	The Human LL-37(17-29) antimicrobial peptide reveals a functional supramolecular structure
title_sort	human ll-37(17-29) antimicrobial peptide reveals a functional supramolecular structure
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/32dc3f228962462da03ce14896285cc7
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The Human LL-37(17-29) antimicrobial peptide reveals a functional supramolecular structure

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