Cell-Associated HIV-1 Unspliced-to-Multiply-Spliced RNA Ratio at 12 Weeks of ART Predicts Immune Reconstitution on Therapy

Human immunodeficiency virus (HIV) infection is currently managed by antiretroviral drugs, which block virus replication and promote immune restoration. However, the latter effect is not universal, with a proportion of infected individuals failing to sufficiently reconstitute their immune function...

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Autores principales:	Mirte Scherpenisse, Neeltje A. Kootstra, Margreet Bakker, Ben Berkhout, Alexander O. Pasternak
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2021
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/32dcdb13ffcc495e9446aa3ff1e69aa0
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spelling	oai:doaj.org-article:32dcdb13ffcc495e9446aa3ff1e69aa02021-11-03T18:56:09ZCell-Associated HIV-1 Unspliced-to-Multiply-Spliced RNA Ratio at 12 Weeks of ART Predicts Immune Reconstitution on Therapy2150-751110.1128/mBio.00099-21https://doaj.org/article/32dcdb13ffcc495e9446aa3ff1e69aa02021-04-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00099-21https://doaj.org/toc/2150-7511 Human immunodeficiency virus (HIV) infection is currently managed by antiretroviral drugs, which block virus replication and promote immune restoration. However, the latter effect is not universal, with a proportion of infected individuals failing to sufficiently reconstitute their immune function despite a successful virological response to antiretroviral therapy (ART).Mirte ScherpenisseNeeltje A. KootstraMargreet BakkerBen BerkhoutAlexander O. PasternakAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 12, Iss 2 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Mirte Scherpenisse Neeltje A. Kootstra Margreet Bakker Ben Berkhout Alexander O. Pasternak Cell-Associated HIV-1 Unspliced-to-Multiply-Spliced RNA Ratio at 12 Weeks of ART Predicts Immune Reconstitution on Therapy
description	Human immunodeficiency virus (HIV) infection is currently managed by antiretroviral drugs, which block virus replication and promote immune restoration. However, the latter effect is not universal, with a proportion of infected individuals failing to sufficiently reconstitute their immune function despite a successful virological response to antiretroviral therapy (ART).
format	article
author	Mirte Scherpenisse Neeltje A. Kootstra Margreet Bakker Ben Berkhout Alexander O. Pasternak
author_facet	Mirte Scherpenisse Neeltje A. Kootstra Margreet Bakker Ben Berkhout Alexander O. Pasternak
author_sort	Mirte Scherpenisse
title	Cell-Associated HIV-1 Unspliced-to-Multiply-Spliced RNA Ratio at 12 Weeks of ART Predicts Immune Reconstitution on Therapy
title_short	Cell-Associated HIV-1 Unspliced-to-Multiply-Spliced RNA Ratio at 12 Weeks of ART Predicts Immune Reconstitution on Therapy
title_full	Cell-Associated HIV-1 Unspliced-to-Multiply-Spliced RNA Ratio at 12 Weeks of ART Predicts Immune Reconstitution on Therapy
title_fullStr	Cell-Associated HIV-1 Unspliced-to-Multiply-Spliced RNA Ratio at 12 Weeks of ART Predicts Immune Reconstitution on Therapy
title_full_unstemmed	Cell-Associated HIV-1 Unspliced-to-Multiply-Spliced RNA Ratio at 12 Weeks of ART Predicts Immune Reconstitution on Therapy
title_sort	cell-associated hiv-1 unspliced-to-multiply-spliced rna ratio at 12 weeks of art predicts immune reconstitution on therapy
publisher	American Society for Microbiology
publishDate	2021
url	https://doaj.org/article/32dcdb13ffcc495e9446aa3ff1e69aa0
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Cell-Associated HIV-1 Unspliced-to-Multiply-Spliced RNA Ratio at 12 Weeks of ART Predicts Immune Reconstitution on Therapy

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