The Importance of Nodule Size in the Management of Ruptured Thyroid Nodule After Radiofrequency Ablation: A Retrospective Study and Literature Review
BackgroundNodule rupture is a relatively uncommon yet severe complication of radiofrequency ablation (RFA). When nodule rupture occurs, determining suitable therapeutic management is a critical issue. A study herein aimed to identify the predictive factors affecting the management of post-RFA nodule...
Guardado en:
| Autores principales: | , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Frontiers Media S.A.
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/32dcf08fed2742c1a332fd1cec7d9350 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:32dcf08fed2742c1a332fd1cec7d9350 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:32dcf08fed2742c1a332fd1cec7d93502021-12-01T07:21:48ZThe Importance of Nodule Size in the Management of Ruptured Thyroid Nodule After Radiofrequency Ablation: A Retrospective Study and Literature Review1664-239210.3389/fendo.2021.776919https://doaj.org/article/32dcf08fed2742c1a332fd1cec7d93502021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fendo.2021.776919/fullhttps://doaj.org/toc/1664-2392BackgroundNodule rupture is a relatively uncommon yet severe complication of radiofrequency ablation (RFA). When nodule rupture occurs, determining suitable therapeutic management is a critical issue. A study herein aimed to identify the predictive factors affecting the management of post-RFA nodule rupture.MethodsPost-RFA nodule rupture data of 9 patients were enrolled from 2 medical centers. A literature investigation was performed, uncovering nodule rupture data of 17 patients. A total of 26 patients were analyzed and divided into two groups, categorized as patients requiring either invasive or conservative therapeutic management. Data including initial symptoms, imaging, therapeutic management, and prognosis were reviewed and compared between the two groups.ResultsSignificant differences in nodule diameter, and the ablation time of the course prior to rupture (RUP time) were noted between the two groups (p = 0.045 and 0.008, respectively). Logistic regression analysis indicated the initial nodule diameter and RUP time significantly affected the requirement of invasive treatment (OR 1.99 and 1.11, respectively). Considering practicality, when a nodule with an initial maximum diameter of >4.5cm ruptured, invasive management was suggested (sensitivity 69% and specificity 79%).ConclusionThough nodule ruptures can be managed conservatively, a ruptured nodule with an initial maximum diameter of >4.5cm may require invasive management. Understanding the significant clinical and imaging features will help physicians make an appropriate risk assessment to determine the correct treatment in a timely manner.Wen-Chieh ChenSheng-Dean LuoWei-Chih ChenChen-Kai ChouYen-Hsiang ChangKai-Lun ChengKai-Lun ChengWei-Che LinFrontiers Media S.A.articlethyroid noduleultrasoundradiofrequency ablationcomplicationnodule ruptureDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENFrontiers in Endocrinology, Vol 12 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
thyroid nodule ultrasound radiofrequency ablation complication nodule rupture Diseases of the endocrine glands. Clinical endocrinology RC648-665 |
| spellingShingle |
thyroid nodule ultrasound radiofrequency ablation complication nodule rupture Diseases of the endocrine glands. Clinical endocrinology RC648-665 Wen-Chieh Chen Sheng-Dean Luo Wei-Chih Chen Chen-Kai Chou Yen-Hsiang Chang Kai-Lun Cheng Kai-Lun Cheng Wei-Che Lin The Importance of Nodule Size in the Management of Ruptured Thyroid Nodule After Radiofrequency Ablation: A Retrospective Study and Literature Review |
| description |
BackgroundNodule rupture is a relatively uncommon yet severe complication of radiofrequency ablation (RFA). When nodule rupture occurs, determining suitable therapeutic management is a critical issue. A study herein aimed to identify the predictive factors affecting the management of post-RFA nodule rupture.MethodsPost-RFA nodule rupture data of 9 patients were enrolled from 2 medical centers. A literature investigation was performed, uncovering nodule rupture data of 17 patients. A total of 26 patients were analyzed and divided into two groups, categorized as patients requiring either invasive or conservative therapeutic management. Data including initial symptoms, imaging, therapeutic management, and prognosis were reviewed and compared between the two groups.ResultsSignificant differences in nodule diameter, and the ablation time of the course prior to rupture (RUP time) were noted between the two groups (p = 0.045 and 0.008, respectively). Logistic regression analysis indicated the initial nodule diameter and RUP time significantly affected the requirement of invasive treatment (OR 1.99 and 1.11, respectively). Considering practicality, when a nodule with an initial maximum diameter of >4.5cm ruptured, invasive management was suggested (sensitivity 69% and specificity 79%).ConclusionThough nodule ruptures can be managed conservatively, a ruptured nodule with an initial maximum diameter of >4.5cm may require invasive management. Understanding the significant clinical and imaging features will help physicians make an appropriate risk assessment to determine the correct treatment in a timely manner. |
| format |
article |
| author |
Wen-Chieh Chen Sheng-Dean Luo Wei-Chih Chen Chen-Kai Chou Yen-Hsiang Chang Kai-Lun Cheng Kai-Lun Cheng Wei-Che Lin |
| author_facet |
Wen-Chieh Chen Sheng-Dean Luo Wei-Chih Chen Chen-Kai Chou Yen-Hsiang Chang Kai-Lun Cheng Kai-Lun Cheng Wei-Che Lin |
| author_sort |
Wen-Chieh Chen |
| title |
The Importance of Nodule Size in the Management of Ruptured Thyroid Nodule After Radiofrequency Ablation: A Retrospective Study and Literature Review |
| title_short |
The Importance of Nodule Size in the Management of Ruptured Thyroid Nodule After Radiofrequency Ablation: A Retrospective Study and Literature Review |
| title_full |
The Importance of Nodule Size in the Management of Ruptured Thyroid Nodule After Radiofrequency Ablation: A Retrospective Study and Literature Review |
| title_fullStr |
The Importance of Nodule Size in the Management of Ruptured Thyroid Nodule After Radiofrequency Ablation: A Retrospective Study and Literature Review |
| title_full_unstemmed |
The Importance of Nodule Size in the Management of Ruptured Thyroid Nodule After Radiofrequency Ablation: A Retrospective Study and Literature Review |
| title_sort |
importance of nodule size in the management of ruptured thyroid nodule after radiofrequency ablation: a retrospective study and literature review |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/32dcf08fed2742c1a332fd1cec7d9350 |
| work_keys_str_mv |
AT wenchiehchen theimportanceofnodulesizeinthemanagementofrupturedthyroidnoduleafterradiofrequencyablationaretrospectivestudyandliteraturereview AT shengdeanluo theimportanceofnodulesizeinthemanagementofrupturedthyroidnoduleafterradiofrequencyablationaretrospectivestudyandliteraturereview AT weichihchen theimportanceofnodulesizeinthemanagementofrupturedthyroidnoduleafterradiofrequencyablationaretrospectivestudyandliteraturereview AT chenkaichou theimportanceofnodulesizeinthemanagementofrupturedthyroidnoduleafterradiofrequencyablationaretrospectivestudyandliteraturereview AT yenhsiangchang theimportanceofnodulesizeinthemanagementofrupturedthyroidnoduleafterradiofrequencyablationaretrospectivestudyandliteraturereview AT kailuncheng theimportanceofnodulesizeinthemanagementofrupturedthyroidnoduleafterradiofrequencyablationaretrospectivestudyandliteraturereview AT kailuncheng theimportanceofnodulesizeinthemanagementofrupturedthyroidnoduleafterradiofrequencyablationaretrospectivestudyandliteraturereview AT weichelin theimportanceofnodulesizeinthemanagementofrupturedthyroidnoduleafterradiofrequencyablationaretrospectivestudyandliteraturereview AT wenchiehchen importanceofnodulesizeinthemanagementofrupturedthyroidnoduleafterradiofrequencyablationaretrospectivestudyandliteraturereview AT shengdeanluo importanceofnodulesizeinthemanagementofrupturedthyroidnoduleafterradiofrequencyablationaretrospectivestudyandliteraturereview AT weichihchen importanceofnodulesizeinthemanagementofrupturedthyroidnoduleafterradiofrequencyablationaretrospectivestudyandliteraturereview AT chenkaichou importanceofnodulesizeinthemanagementofrupturedthyroidnoduleafterradiofrequencyablationaretrospectivestudyandliteraturereview AT yenhsiangchang importanceofnodulesizeinthemanagementofrupturedthyroidnoduleafterradiofrequencyablationaretrospectivestudyandliteraturereview AT kailuncheng importanceofnodulesizeinthemanagementofrupturedthyroidnoduleafterradiofrequencyablationaretrospectivestudyandliteraturereview AT kailuncheng importanceofnodulesizeinthemanagementofrupturedthyroidnoduleafterradiofrequencyablationaretrospectivestudyandliteraturereview AT weichelin importanceofnodulesizeinthemanagementofrupturedthyroidnoduleafterradiofrequencyablationaretrospectivestudyandliteraturereview |
| _version_ |
1718405403961720832 |