HIV-1 replication complexes accumulate in nuclear speckles and integrate into speckle-associated genomic domains

HIV-1 replication complexes accumulate in nuclear speckles and integrate into speckle-associated genomic domains

Early steps of HIV infection of primary human cells remain poorly understood. Here, Francis et al. show that early viral replication complexes accumulate within nuclear speckles, in reliance on viral capsid/host CPSF6 interactions, and preferentially integrate in speckle-associated genomic domains.

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Detalles Bibliográficos
Autores principales: Ashwanth C. Francis, Mariana Marin, Parmit K. Singh, Vasudevan Achuthan, Mathew J. Prellberg, Kristina Palermino-Rowland, Shuiyun Lan, Philip R. Tedbury, Stefan G. Sarafianos, Alan N. Engelman, Gregory B. Melikyan
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Science
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Acceso en línea:https://doaj.org/article/32dd990260c242f794d380d0f1625892
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Sumario:Early steps of HIV infection of primary human cells remain poorly understood. Here, Francis et al. show that early viral replication complexes accumulate within nuclear speckles, in reliance on viral capsid/host CPSF6 interactions, and preferentially integrate in speckle-associated genomic domains.

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